{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hypoxic-ischemic+Encephalopathy",
    "query": {
      "condition": "Hypoxic-ischemic Encephalopathy"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 85,
    "total_pages": 9,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Hypoxic-ischemic+Encephalopathy&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-10T13:15:20.365Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00005772",
      "title": "Whole-Body Cooling for Birth Asphyxia in Term Infants",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Infant, Newborn",
        "Hypoxia-Ischemia, Brain"
      ],
      "interventions": [
        {
          "name": "Induced hypothermia",
          "type": "DEVICE"
        },
        {
          "name": "Control",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "NICHD Neonatal Research Network",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "6 Hours",
        "sex": "ALL",
        "summary": "Up to 6 Hours"
      },
      "enrollment_count": 208,
      "start_date": "1999-10",
      "completion_date": "2010-07",
      "has_results": false,
      "last_update_posted_date": "2019-03-22",
      "last_synced_at": "2026-06-10T13:15:20.365Z",
      "location_count": 16,
      "location_summary": "Birmingham, Alabama • Palo Alto, California • New Haven, Connecticut + 13 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00005772"
    },
    {
      "nct_id": "NCT05376267",
      "title": "Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cardiac Arrest, Out-Of-Hospital",
        "Hypothermia, Induced",
        "Hypoxia-Ischemia, Brain"
      ],
      "interventions": [
        {
          "name": "Therapeutic Hypothermia",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Days",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "2 Days to 17 Years"
      },
      "enrollment_count": 900,
      "start_date": "2022-08-05",
      "completion_date": "2028-03-31",
      "has_results": false,
      "last_update_posted_date": "2026-06-05",
      "last_synced_at": "2026-06-10T13:15:20.365Z",
      "location_count": 50,
      "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 43 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05376267"
    },
    {
      "nct_id": "NCT05491980",
      "title": "Florida Cerebrovascular Disease Biorepository and Genomics Center",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cerebrovascular Disease",
        "Ischemic Stroke",
        "Transient Ischemic Attack",
        "Intracerebral Hemorrhage",
        "Aneurysmal Subarachnoid Hemorrhage",
        "Vascular Dementia",
        "Anoxic Brain Injury",
        "Unruptured Intracranial Aneurysm",
        "Carotid Artery Stenosis Symptomatic",
        "Asymptomatic Carotid Artery Stenosis",
        "Non-Aneurysmal Perimesencephalic Subarachnoid Haemorrhage",
        "Cerebral Venous Thrombosis",
        "Moyamoya Disease",
        "Fibromuscular Dysplasia",
        "Subarachnoid Hemorrhage",
        "Leukoaraiosis",
        "Arteriovenous Fistula",
        "Reversible Cerebral Vasoconstriction Syndrome",
        "CADASIL"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 72,
      "start_date": "2022-08-02",
      "completion_date": "2026-06",
      "has_results": false,
      "last_update_posted_date": "2026-05-13",
      "last_synced_at": "2026-06-10T13:15:20.365Z",
      "location_count": 1,
      "location_summary": "Jacksonville, Florida",
      "locations": [
        {
          "city": "Jacksonville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05491980"
    },
    {
      "nct_id": "NCT07165938",
      "title": "Genetics of Neonatal Encephalopathy and Related Disorders",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Neonatal Encephalopathy",
        "Hypoxic Ischaemic Encephalopathy (HIE)"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Boston Children's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 300,
      "start_date": "2026-02-04",
      "completion_date": "2035-09",
      "has_results": false,
      "last_update_posted_date": "2026-03-11",
      "last_synced_at": "2026-06-10T13:15:20.365Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07165938"
    },
    {
      "nct_id": "NCT01913340",
      "title": "Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Hypoxic-ischemic Encephalopathy",
        "Neonatal Encephalopathy",
        "Birth Asphyxia"
      ],
      "interventions": [
        {
          "name": "Erythropoietin",
          "type": "DRUG"
        },
        {
          "name": "Normal saline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Minutes",
        "maximum_age": "24 Hours",
        "sex": "ALL",
        "summary": "30 Minutes to 24 Hours"
      },
      "enrollment_count": 50,
      "start_date": "2013-09",
      "completion_date": "2016-09",
      "has_results": true,
      "last_update_posted_date": "2020-07-13",
      "last_synced_at": "2026-06-10T13:15:20.365Z",
      "location_count": 7,
      "location_summary": "Little Rock, Arkansas • Palo Alto, California • San Francisco, California + 4 more",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Santa Clara",
          "state": "California"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01913340"
    },
    {
      "nct_id": "NCT03112486",
      "title": "Out-of-hospital Cardiac Arrest (OHCA) Biomarkers",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Neurological Outcome",
        "Cardiac Arrest",
        "Out-Of-Hospital Cardiac Arrest",
        "Brain Anoxia Ischemia",
        "Hypoxia, Brain",
        "Hypoxia-Ischemia, Brain",
        "Cardiac Arrest With Successful Resuscitation",
        "Cardiac Arrest, Out-Of-Hospital",
        "Brain Injuries"
      ],
      "interventions": [
        {
          "name": "blood draw",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 32,
      "start_date": "2017-05-26",
      "completion_date": "2020-01-28",
      "has_results": false,
      "last_update_posted_date": "2020-05-08",
      "last_synced_at": "2026-06-10T13:15:20.365Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03112486"
    },
    {
      "nct_id": "NCT03635450",
      "title": "Study of hCT-MSC in Newborn Infants With Moderate or Severe HIE",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Moderate to Severe Hypoxic-ischemic Encephalopathy"
      ],
      "interventions": [
        {
          "name": "Infusion of hCT-MSC",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Joanne Kurtzberg, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "0 Hours",
        "maximum_age": "48 Hours",
        "sex": "ALL",
        "summary": "0 Hours to 48 Hours"
      },
      "enrollment_count": 6,
      "start_date": "2018-12-27",
      "completion_date": "2020-12-28",
      "has_results": false,
      "last_update_posted_date": "2024-04-12",
      "last_synced_at": "2026-06-10T13:15:20.365Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03635450"
    },
    {
      "nct_id": "NCT03327467",
      "title": "Expanded Access Protocol: Umbilical Cord Blood Infusions for Children With Brain Injuries",
      "overall_status": "AVAILABLE",
      "study_type": "EXPANDED_ACCESS",
      "phases": [],
      "conditions": [
        "Cerebral Palsy",
        "Hydrocephalus",
        "Apraxia of Speech",
        "Hypoxia Ischemia, Cerebral",
        "Drowning; Anoxia"
      ],
      "interventions": [
        {
          "name": "Cord Blood Infusion",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Joanne Kurtzberg, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "26 Years",
        "sex": "ALL",
        "summary": "Up to 26 Years"
      },
      "enrollment_count": null,
      "start_date": null,
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2026-01-23",
      "last_synced_at": "2026-06-10T13:15:20.365Z",
      "location_count": 2,
      "location_summary": "New Brunswick, New Jersey • Durham, North Carolina",
      "locations": [
        {
          "city": "New Brunswick",
          "state": "New Jersey"
        },
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03327467"
    },
    {
      "nct_id": "NCT00614744",
      "title": "Late Hypothermia for Hypoxic-Ischemic Encephalopathy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Infant, Newborn",
        "Hypoxia, Brain",
        "Hypoxia-Ischemia, Brain",
        "Encephalopathy, Hypoxic-Ischemic",
        "Hypoxic-Ischemic Encephalopathy",
        "Ischemic-Hypoxic Encephalopathy"
      ],
      "interventions": [
        {
          "name": "Hypothermia",
          "type": "PROCEDURE"
        },
        {
          "name": "Normothermic Control",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "NICHD Neonatal Research Network",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "6 Hours",
        "maximum_age": "24 Hours",
        "sex": "ALL",
        "summary": "6 Hours to 24 Hours"
      },
      "enrollment_count": 168,
      "start_date": "2008-04",
      "completion_date": "2016-06",
      "has_results": true,
      "last_update_posted_date": "2021-03-09",
      "last_synced_at": "2026-06-10T13:15:20.365Z",
      "location_count": 22,
      "location_summary": "Birmingham, Alabama • Los Angeles, California • Palo Alto, California + 18 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00614744"
    },
    {
      "nct_id": "NCT03743805",
      "title": "Rapid Reversal of CNS-Depressant Drug Effect Prior to Brain Death Determination",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Brain Death",
        "Anoxic Brain Injury",
        "Cardiac Arrest",
        "Sedative Intoxication",
        "Narcotic Intoxication"
      ],
      "interventions": [
        {
          "name": "Flumazenil",
          "type": "DRUG"
        },
        {
          "name": "Naloxone",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Prisma Health-Midlands",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2019-01-01",
      "completion_date": "2021-07-21",
      "has_results": false,
      "last_update_posted_date": "2024-10-31",
      "last_synced_at": "2026-06-10T13:15:20.365Z",
      "location_count": 1,
      "location_summary": "Columbia, South Carolina",
      "locations": [
        {
          "city": "Columbia",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03743805"
    }
  ]
}