{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Immune+Defect&page=2", "query": { "condition": "Immune Defect", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Immune+Defect&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-07-23T15:50:22.818Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03412760", "title": "Hydrops: Diagnosing & Redefining Outcomes With Precision Study", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Hydrops Fetalis", "Birth Defect", "Fetal Anomaly" ], "interventions": [ { "name": "Exome sequencing", "type": "DIAGNOSTIC_TEST" } ], "intervention_types": [ "DIAGNOSTIC_TEST" ], "sponsor": "University of California, San Francisco", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 500, "start_date": "2018-10-11", "completion_date": "2027-02", "has_results": false, "last_update_posted_date": "2026-04-17", "last_synced_at": "2026-07-23T15:50:22.818Z", "location_count": 1, "location_summary": "San Francisco, California", "locations": [ { "city": "San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03412760" }, { "nct_id": "NCT04306939", "title": "Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study", "overall_status": "SUSPENDED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Chronic Pancreatitis", "Inflammatory Bowel Diseases", "Hepatitis", "NASH - Nonalcoholic Steatohepatitis", "Acute Pancreatitis", "Rheumatoid Arthritis", "Diabetes Mellitus", "Dyslipidemias", "Multiple Sclerosis", "Irritable Bowel Syndrome", "Chronic Pain", "Chronic Disease", "Chronic Kidney Diseases", "Crohn Disease", "Celiac Disease", "Biliary Cirrhosis", "Bile Acid Synthesis Defect", "Gastritis", "Cholecystitis", "Cholelithiases", "IPMN", "Cyst Pancreas", "Cystic Fibrosis", "Pancreatic Exocrine Insufficiency", "Diarrhea Chronic", "Constipation - Functional", "Constipation Chronic Idiopathic" ], "interventions": [ { "name": "venipuncture", "type": "OTHER" }, { "name": "Questionnaires", "type": "BEHAVIORAL" }, { "name": "Additional Sample Collections", "type": "OTHER" } ], "intervention_types": [ "OTHER", "BEHAVIORAL" ], "sponsor": "University of Pittsburgh", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 120000, "start_date": "2014-11-01", "completion_date": "2026-12", "has_results": false, "last_update_posted_date": "2026-01-07", "last_synced_at": "2026-07-23T15:50:22.818Z", "location_count": 1, "location_summary": "Pittsburgh, Pennsylvania", "locations": [ { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT04306939" }, { "nct_id": "NCT05287841", "title": "Does Batten Grafting Improve Nasal Outcomes in Septoplasty and Turbinate Reduction?", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Nasal Obstruction", "Septal Defect", "Allergic Rhinitis", "Nasal Polyps", "Nasal Valve Collapse" ], "interventions": [ { "name": "Batten batten graft", "type": "PROCEDURE" }, { "name": "Septoplasty", "type": "PROCEDURE" }, { "name": "Inferior Turbinate Reduction", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE" ], "sponsor": "Northwell Health", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 96, "start_date": "2021-04-30", "completion_date": "2025-06-15", "has_results": false, "last_update_posted_date": "2024-09-20", "last_synced_at": "2026-07-23T15:50:22.818Z", "location_count": 3, "location_summary": "Poplar Bluff, Missouri • New York, New York • Staten Island, New York", "locations": [ { "city": "Poplar Bluff", "state": "Missouri" }, { "city": "New York", "state": "New York" }, { "city": "Staten Island", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT05287841" }, { "nct_id": "NCT02775656", "title": "UCB Cimzia Pregnancy Follow-up Study", "overall_status": "TERMINATED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Rheumatoid Arthritis (RA)", "Crohn's Disease (CD)", "Psoriatic Arthritis (PsA)", "Axial Spondyloarthritis and Ankylosing Spondylitis" ], "interventions": [], "intervention_types": [], "sponsor": "UCB BIOSCIENCES, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "64 Years", "sex": "FEMALE", "summary": "18 Years to 64 Years · Female only" }, "enrollment_count": 1, "start_date": "2016-11", "completion_date": "2017-12", "has_results": false, "last_update_posted_date": "2021-04-22", "last_synced_at": "2026-07-23T15:50:22.818Z", "location_count": 1, "location_summary": "Wilmington, North Carolina", "locations": [ { "city": "Wilmington", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT02775656" }, { "nct_id": "NCT01596699", "title": "Pilot Trial of Clofarabine Added to Standard Busulfan and Fludarabine for Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Myeloid Malignancy", "Bone Marrow Failure Syndrome", "Transfusion-dependent Red Blood Cell (RBC) Defect", "Congenital Immunodeficiency", "Metabolic Disease", "Severe Immune Dysregulation" ], "interventions": [ { "name": "Alemtuzumab", "type": "DRUG" }, { "name": "Busulfan", "type": "DRUG" }, { "name": "Fludarabine", "type": "DRUG" }, { "name": "Clofarabine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of California, San Francisco", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "3 Months", "maximum_age": "30 Years", "sex": "ALL", "summary": "3 Months to 30 Years" }, "enrollment_count": 16, "start_date": "2012-05-24", "completion_date": "2019-06", "has_results": true, "last_update_posted_date": "2020-02-26", "last_synced_at": "2026-07-23T15:50:22.818Z", "location_count": 1, "location_summary": "San Francisco, California", "locations": [ { "city": "San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01596699" }, { "nct_id": "NCT04885179", "title": "SPL Insufficiency Syndrome (SPLIS)/NPHS14: a SPLIS Observational Study and Patient Registry (International)", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Sphingolipidoses", "Enzyme Deficiency" ], "interventions": [ { "name": "no intervention", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "University of California, San Francisco", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 120, "start_date": "2025-04-22", "completion_date": "2028-12-30", "has_results": false, "last_update_posted_date": "2025-10-24", "last_synced_at": "2026-07-23T15:50:22.818Z", "location_count": 1, "location_summary": "San Francisco, California", "locations": [ { "city": "San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04885179" }, { "nct_id": "NCT04261790", "title": "Effects of Ocrelizumab on B-cell Tolerance Defect in Relapsing Multiple Sclerosis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Multiple Sclerosis, Relapsing-Remitting" ], "interventions": [ { "name": "Ocrelizumab", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Johns Hopkins University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "99 Years", "sex": "ALL", "summary": "18 Years to 99 Years" }, "enrollment_count": 10, "start_date": "2020-08-01", "completion_date": "2024-11-01", "has_results": true, "last_update_posted_date": "2025-02-17", "last_synced_at": "2026-07-23T15:50:22.818Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT04261790" }, { "nct_id": "NCT01852370", "title": "Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases", "overall_status": "ENROLLING_BY_INVITATION", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Severe Combined Immunodeficiency (SCID)", "Immunodeficiency With Predominant T-cell Defect, Unspecified", "Severe Chronic Neutropenia", "Chronic Granulomatous Disease (CGD)", "Hyper IgE Syndromes", "Hyper IgM Deficiencies", "Wiskott-Aldrich Syndrome", "Mendelian Susceptibility to Mycobacterial Disease", "Common Variable Immune Deficiency (CVID)" ], "interventions": [ { "name": "CD3/CD19 negative allogeneic hematopoietic stem cells", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Paul Szabolcs", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "5 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "5 Years to 45 Years" }, "enrollment_count": 16, "start_date": "2013-06-20", "completion_date": "2027-11", "has_results": false, "last_update_posted_date": "2025-12-15", "last_synced_at": "2026-07-23T15:50:22.818Z", "location_count": 1, "location_summary": "Pittsburgh, Pennsylvania", "locations": [ { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT01852370" }, { "nct_id": "NCT01288014", "title": "Cytokine Production and Immunity to Varicella Zoster Virus (VZV) in Elderly Recipients of Zoster Vaccine", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Immunity; Defect Due to Antibody or Cell Mediated Immune Defect" ], "interventions": [], "intervention_types": [], "sponsor": "Columbia University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "60 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "60 Years to 80 Years" }, "enrollment_count": 26, "start_date": "2011-01", "completion_date": "2012-03", "has_results": false, "last_update_posted_date": "2017-07-19", "last_synced_at": "2026-07-23T15:50:22.818Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT01288014" }, { "nct_id": "NCT02103361", "title": "Stelara and Tremfya Pregnancy Exposure Registry OTIS Autoimmune Diseases in Pregnancy Project", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Psoriasis", "Pregnancy", "Psoriatic Arthritis", "Crohn Disease" ], "interventions": [ { "name": "Ustekinumab", "type": "DRUG" }, { "name": "Guselkumab", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of California, San Diego", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "FEMALE", "summary": "Female only" }, "enrollment_count": 200, "start_date": "2013-11", "completion_date": "2031-02", "has_results": false, "last_update_posted_date": "2025-01-28", "last_synced_at": "2026-07-23T15:50:22.818Z", "location_count": 1, "location_summary": "La Jolla, California", "locations": [ { "city": "La Jolla", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02103361" } ] }