{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Initial+Caries",
    "query": {
      "condition": "Initial Caries"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 3,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T06:44:39.783Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04933331",
      "title": "Early Caries Lesion Management Observational Study",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Initial Caries",
        "Arrested Dental Caries",
        "Cavitated Caries",
        "Dental Caries",
        "Dental Caries in Children"
      ],
      "interventions": [
        {
          "name": "Curodont Repair Fluoride Plus",
          "type": "DRUG"
        },
        {
          "name": "Silver Diamine Fluoride",
          "type": "DEVICE"
        },
        {
          "name": "Glass Ionomer Sealant",
          "type": "DEVICE"
        },
        {
          "name": "Fluoride varnish",
          "type": "DEVICE"
        },
        {
          "name": "Fluoride toothpaste",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "CareQuest Institute for Oral Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "4 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "4 Years and older"
      },
      "enrollment_count": 744,
      "start_date": "2020-12-07",
      "completion_date": "2024-03-31",
      "has_results": false,
      "last_update_posted_date": "2023-11-24",
      "last_synced_at": "2026-05-22T06:44:39.783Z",
      "location_count": 4,
      "location_summary": "Dothan, Alabama • Westborough, Massachusetts • Bend, Oregon + 1 more",
      "locations": [
        {
          "city": "Dothan",
          "state": "Alabama"
        },
        {
          "city": "Westborough",
          "state": "Massachusetts"
        },
        {
          "city": "Bend",
          "state": "Oregon"
        },
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04933331"
    },
    {
      "nct_id": "NCT00847470",
      "title": "DPBRN Reasons for Placing the First Restoration on Permanent Tooth Surfaces",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Dental Practice-Based Research Network",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "6 Years and older"
      },
      "enrollment_count": 5810,
      "start_date": "2006-06",
      "completion_date": "2008-12",
      "has_results": false,
      "last_update_posted_date": "2014-11-18",
      "last_synced_at": "2026-05-22T06:44:39.783Z",
      "location_count": 6,
      "location_summary": "Birmingham, Alabama • Gainesville, Florida • Minneapolis, Minnesota + 1 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Gainesville",
          "state": "Florida"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00847470"
    },
    {
      "nct_id": "NCT07091422",
      "title": "A Split-Mouth Clinical Trial Evaluating the Bond Failure Rate of a New Etch-Free Orthodontic Adhesive",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Bracket Bonding",
        "Orthodontic Treatment",
        "Dental Adhesives/Restorations Performance",
        "White Spot Lesion of Tooth"
      ],
      "interventions": [
        {
          "name": "Etch-Free Adhesive",
          "type": "DEVICE"
        },
        {
          "name": "Conventional Etch-and-Bond Adhesive",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Maryland, Baltimore",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "14 Years to 35 Years"
      },
      "enrollment_count": 20,
      "start_date": "2025-11-05",
      "completion_date": "2026-12-01",
      "has_results": false,
      "last_update_posted_date": "2025-11-10",
      "last_synced_at": "2026-05-22T06:44:39.783Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07091422"
    }
  ]
}