{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Injuries%2C+Acute+Brain&page=2",
    "query": {
      "condition": "Injuries, Acute Brain",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Injuries%2C+Acute+Brain&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T09:47:16.681Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02525432",
      "title": "Autologous Stem Cell Study for Adult TBI (Phase 2b)",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Brain Injuries, Traumatic",
        "Brain Injuries, Acute",
        "TBI (Traumatic Brain Injury)"
      ],
      "interventions": [
        {
          "name": "Placebo Infusion",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Autologous BMMNC Infusion",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 37,
      "start_date": "2016-11-21",
      "completion_date": "2025-01",
      "has_results": false,
      "last_update_posted_date": "2024-05-09",
      "last_synced_at": "2026-07-22T09:47:16.681Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02525432"
    },
    {
      "nct_id": "NCT04731974",
      "title": "Acute Concussion and Melatonin",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Concussion, Mild",
        "Concussion, Brain",
        "Pediatric ALL"
      ],
      "interventions": [
        {
          "name": "Melatonin 3 MG",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Children's National Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "12 Years to 18 Years"
      },
      "enrollment_count": 254,
      "start_date": "2023-03-01",
      "completion_date": "2024-06-30",
      "has_results": false,
      "last_update_posted_date": "2024-02-07",
      "last_synced_at": "2026-07-22T09:47:16.681Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04731974"
    },
    {
      "nct_id": "NCT03281590",
      "title": "Stroke and Cerebrovascular Diseases Registry",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Stroke",
        "Acute Stroke",
        "Acute Brain Injury",
        "Ischemic Stroke",
        "Hemorrhagic Stroke",
        "Transient Ischemic Attack",
        "Subarachnoid Hemorrhage",
        "Cerebral Ischemia",
        "Cerebral Infarction",
        "Cerebral Stroke",
        "Venous Sinus Thrombosis, Cranial"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of New Mexico",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "1 Year and older"
      },
      "enrollment_count": 4594,
      "start_date": "2017-09-06",
      "completion_date": "2022-06-10",
      "has_results": false,
      "last_update_posted_date": "2022-08-22",
      "last_synced_at": "2026-07-22T09:47:16.681Z",
      "location_count": 1,
      "location_summary": "Albuquerque, New Mexico",
      "locations": [
        {
          "city": "Albuquerque",
          "state": "New Mexico"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03281590"
    },
    {
      "nct_id": "NCT03148340",
      "title": "Volumetric Integral Phase-shift Spectroscopy for Noninvasive Detection of Hemispheric Bioimpedance Asymmetry in Acute Brain Pathology",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Stroke",
        "Stroke, Acute",
        "Ischemic Stroke",
        "Hemorrhage",
        "Clot (Blood); Brain",
        "Subarachnoid Hemorrhage",
        "Cerebral Infarction",
        "Cerebral Hemorrhage",
        "Cerebral Stroke",
        "Intracerebral Hemorrhage",
        "Intracerebral Injury"
      ],
      "interventions": [
        {
          "name": "VIPS Monitoring",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Cerebrotech Medical Systems, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 287,
      "start_date": "2017-04-14",
      "completion_date": "2018-07-15",
      "has_results": false,
      "last_update_posted_date": "2018-12-12",
      "last_synced_at": "2026-07-22T09:47:16.681Z",
      "location_count": 5,
      "location_summary": "Jacksonville, Florida • Buffalo, New York • New York, New York + 2 more",
      "locations": [
        {
          "city": "Jacksonville",
          "state": "Florida"
        },
        {
          "city": "Buffalo",
          "state": "New York"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Charleston",
          "state": "South Carolina"
        },
        {
          "city": "Memphis",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03148340"
    },
    {
      "nct_id": "NCT06465290",
      "title": "Promoting Neuroplastic Changes of Patients With TBI",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "Motor relearning training with wearable ankle robot",
          "type": "DEVICE"
        },
        {
          "name": "Passive stretching with wearable ankle robot",
          "type": "DEVICE"
        },
        {
          "name": "Gamed-based active movement training with wearable ankle robot",
          "type": "DEVICE"
        },
        {
          "name": "Passive movement with limited wearable ankle robot",
          "type": "DEVICE"
        },
        {
          "name": "Active movement training with limited wearable ankle robot",
          "type": "DEVICE"
        },
        {
          "name": "Ankle/Wrist torque and motion measurement with limited wearable ankle/wrist robot",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Maryland, Baltimore",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "30 Years to 85 Years"
      },
      "enrollment_count": 100,
      "start_date": "2026-07-16",
      "completion_date": "2030-08-31",
      "has_results": false,
      "last_update_posted_date": "2026-07-17",
      "last_synced_at": "2026-07-22T09:47:16.681Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06465290"
    },
    {
      "nct_id": "NCT05761925",
      "title": "The COMA Family Program: A Skills-Based Resiliency Program for Caregivers of Patients With Severe Acute Brain Injuries",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Coma",
        "Emotional Distress"
      ],
      "interventions": [
        {
          "name": "COMA-F",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2024-04-16",
      "completion_date": "2025-05-01",
      "has_results": false,
      "last_update_posted_date": "2025-05-25",
      "last_synced_at": "2026-07-22T09:47:16.681Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05761925"
    },
    {
      "nct_id": "NCT04058132",
      "title": "Cerebrovascular Reactivity Assessed With fNIRS as a Biomarker of TCVI After Acute Traumatic Brain Injury in Military",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "Sildenafil Citrate 50Mg Tab",
          "type": "DRUG"
        },
        {
          "name": "functional Near-infrared Spectroscopy (fNIRS)",
          "type": "DEVICE"
        },
        {
          "name": "Carbon Dioxide (CO2) 5%",
          "type": "OTHER"
        },
        {
          "name": "Neuropsychological Assessments",
          "type": "OTHER"
        },
        {
          "name": "Gadolinium contrast infusion",
          "type": "DRUG"
        },
        {
          "name": "Blood sample collection for research purposes",
          "type": "PROCEDURE"
        },
        {
          "name": "Structural brain Magnetic Resonance Imaging (MRI",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE",
        "OTHER",
        "PROCEDURE"
      ],
      "sponsor": "Uniformed Services University of the Health Sciences",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 1,
      "start_date": "2019-08-09",
      "completion_date": "2020-03-01",
      "has_results": false,
      "last_update_posted_date": "2024-02-28",
      "last_synced_at": "2026-07-22T09:47:16.681Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04058132"
    },
    {
      "nct_id": "NCT02791880",
      "title": "Acute Kidney Injury Genomics and Biomarkers in TAVR Study",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Acute Kidney Injury",
        "Renal Insufficiency, Chronic",
        "Heart Failure",
        "Myocardial Infarction",
        "Arrhythmias, Cardiac",
        "Stroke"
      ],
      "interventions": [
        {
          "name": "Transcatheter Aortic Valve Replacement",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Texas Southwestern Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 62,
      "start_date": "2016-10-25",
      "completion_date": "2031-03-31",
      "has_results": false,
      "last_update_posted_date": "2025-07-29",
      "last_synced_at": "2026-07-22T09:47:16.681Z",
      "location_count": 3,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        },
        {
          "city": "Dallas",
          "state": "Texas"
        },
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02791880"
    },
    {
      "nct_id": "NCT02069613",
      "title": "Multimodal Approach to Testing the Acute Effects of Mild Traumatic Brain Injury (mTBI)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Concussion, Mild"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Huntington Medical Research Institutes",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 44,
      "start_date": "2014-03",
      "completion_date": "2017-08-01",
      "has_results": false,
      "last_update_posted_date": "2017-11-08",
      "last_synced_at": "2026-07-22T09:47:16.681Z",
      "location_count": 3,
      "location_summary": "Pasadena, California",
      "locations": [
        {
          "city": "Pasadena",
          "state": "California"
        },
        {
          "city": "Pasadena",
          "state": "California"
        },
        {
          "city": "Pasadena",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02069613"
    },
    {
      "nct_id": "NCT04890639",
      "title": "Acute Intermittent Hypoxia in Traumatic Brain Injury",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Brain Injuries, Traumatic"
      ],
      "interventions": [
        {
          "name": "Acute Intermittent Hypoxia",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Shirley Ryan AbilityLab",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 12,
      "start_date": "2022-03-15",
      "completion_date": "2024-01-29",
      "has_results": true,
      "last_update_posted_date": "2026-02-18",
      "last_synced_at": "2026-07-22T09:47:16.681Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04890639"
    }
  ]
}