{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Insulin+Resistance+and+Type+2+Diabetes",
    "query": {
      "condition": "Insulin Resistance and Type 2 Diabetes"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 307,
    "total_pages": 31,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Insulin+Resistance+and+Type+2+Diabetes&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-29T21:34:04.242Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04285554",
      "title": "Evaluation of the Integrated Radio Frequency Denervation System to Improve Glycemic Control in Type 2 Diabetic Subjects",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Diabetes Mellitus, Type 2"
      ],
      "interventions": [
        {
          "name": "iRF System Hepatic Denervation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Metavention",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "22 Years to 70 Years"
      },
      "enrollment_count": 15,
      "start_date": "2020-07-28",
      "completion_date": "2022-12-19",
      "has_results": false,
      "last_update_posted_date": "2023-03-15",
      "last_synced_at": "2026-09-29T21:34:04.242Z",
      "location_count": 8,
      "location_summary": "Birmingham, Alabama • Stanford, California • Orlando, Florida + 5 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "Orlando",
          "state": "Florida"
        },
        {
          "city": "Springfield",
          "state": "Illinois"
        },
        {
          "city": "Coon Rapids",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04285554"
    },
    {
      "nct_id": "NCT00627484",
      "title": "Changes in Insulin Sensitivity After Weight Loss",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Obesity",
        "Type 2 Diabetes Mellitus",
        "Insulin Resistance"
      ],
      "interventions": [
        {
          "name": "Gastric bypass",
          "type": "PROCEDURE"
        },
        {
          "name": "Gastric banding",
          "type": "PROCEDURE"
        },
        {
          "name": "Sleeve gastrectomy",
          "type": "PROCEDURE"
        },
        {
          "name": "Very low calorie diet",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "BEHAVIORAL"
      ],
      "sponsor": "Columbia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 119,
      "start_date": "2005-03-01",
      "completion_date": "2018-06-17",
      "has_results": false,
      "last_update_posted_date": "2019-09-19",
      "last_synced_at": "2026-09-29T21:34:04.242Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00627484"
    },
    {
      "nct_id": "NCT00849849",
      "title": "Comprehensive Postpartum Screening Strategies for Women With Gestational Diabetes Mellitus (GDM)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Diabetes Mellitus, Type 2"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Woman's",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 40 Years · Female only"
      },
      "enrollment_count": 214,
      "start_date": "2011-07",
      "completion_date": "2013-12",
      "has_results": false,
      "last_update_posted_date": "2014-12-18",
      "last_synced_at": "2026-09-29T21:34:04.242Z",
      "location_count": 1,
      "location_summary": "Baton Rouge, Louisiana",
      "locations": [
        {
          "city": "Baton Rouge",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00849849"
    },
    {
      "nct_id": "NCT03263351",
      "title": "Depression & Insulin Sensitivity in Adolescents",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Type2 Diabetes",
        "Type 2 Diabetes Mellitus",
        "Insulin Sensitivity",
        "Insulin Resistance",
        "Depression",
        "Adolescent Obesity"
      ],
      "interventions": [
        {
          "name": "Cognitive-behavioral therapy group",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Health education group",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Colorado State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "17 Years",
        "sex": "FEMALE",
        "summary": "12 Years to 17 Years · Female only"
      },
      "enrollment_count": 147,
      "start_date": "2017-10-01",
      "completion_date": "2025-05-26",
      "has_results": false,
      "last_update_posted_date": "2025-09-23",
      "last_synced_at": "2026-09-29T21:34:04.242Z",
      "location_count": 1,
      "location_summary": "Aurora, Colorado",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03263351"
    },
    {
      "nct_id": "NCT06867198",
      "title": "Peanuts for Cardiometabolic, Brain, and Intestinal Health",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Prediabetes",
        "Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)",
        "Cognition",
        "Microvascular Function",
        "Gut Microbiota",
        "Endothelial Function (Reactive Hyperemia)",
        "Arterial Stiffness, Blood Pressure",
        "Adult"
      ],
      "interventions": [
        {
          "name": "Peanuts",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Georgia State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "59 Years",
        "sex": "ALL",
        "summary": "20 Years to 59 Years"
      },
      "enrollment_count": 72,
      "start_date": "2025-03-06",
      "completion_date": "2027-09",
      "has_results": false,
      "last_update_posted_date": "2026-09-02",
      "last_synced_at": "2026-09-29T21:34:04.242Z",
      "location_count": 1,
      "location_summary": "Atlanta, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06867198"
    },
    {
      "nct_id": "NCT00606034",
      "title": "U-500R Insulin In Type 2 Diabetes With Severe Insulin Resistance Via Omnipod",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Type 2 Diabetes",
        "Insulin Resistance"
      ],
      "interventions": [
        {
          "name": "U-500 Insulin delivered by Omnipod (disposable insulin pump)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Mountain Diabetes and Endocrine Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 21,
      "start_date": "2007-12",
      "completion_date": "2009-07",
      "has_results": true,
      "last_update_posted_date": "2014-02-06",
      "last_synced_at": "2026-09-29T21:34:04.242Z",
      "location_count": 1,
      "location_summary": "Asheville, North Carolina",
      "locations": [
        {
          "city": "Asheville",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00606034"
    },
    {
      "nct_id": "NCT00724087",
      "title": "Sleep Loss and Energy Metabolism in People With Family History of Type 2 Diabetes.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sleep",
        "Sleep Deprivation",
        "Insulin Resistance",
        "Type 2 Diabetes"
      ],
      "interventions": [
        {
          "name": "5.5-hour bedtime",
          "type": "OTHER"
        },
        {
          "name": "8.5-hour bedtime",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "21 Years to 40 Years"
      },
      "enrollment_count": 12,
      "start_date": "2008-07",
      "completion_date": "2012-03",
      "has_results": false,
      "last_update_posted_date": "2013-09-05",
      "last_synced_at": "2026-09-29T21:34:04.242Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00724087"
    },
    {
      "nct_id": "NCT01837680",
      "title": "Glycemic Control Using Insulin Levemir Versus Insulin NPH for Diabetes in Pregnancy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Diabetes, Gestational",
        "Diabetes, Type 2"
      ],
      "interventions": [
        {
          "name": "Insulin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "St. Luke's-Roosevelt Hospital Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 105,
      "start_date": "2013-03",
      "completion_date": "2015-03",
      "has_results": true,
      "last_update_posted_date": "2017-05-30",
      "last_synced_at": "2026-09-29T21:34:04.242Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01837680"
    },
    {
      "nct_id": "NCT06606327",
      "title": "Diazoxide Suppression Test P&F Study",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Insulin Resistance",
        "Hyperinsulinemia",
        "Obesity"
      ],
      "interventions": [
        {
          "name": "Diazoxide, 3 mg/kg per dose",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Columbia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 1,
      "start_date": "2024-10-23",
      "completion_date": "2026-06-10",
      "has_results": false,
      "last_update_posted_date": "2026-08-07",
      "last_synced_at": "2026-09-29T21:34:04.242Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06606327"
    },
    {
      "nct_id": "NCT06138821",
      "title": "Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obesity",
        "Liver Diseases",
        "Liver Fibrosis",
        "Liver Fat",
        "Metabolic Dysfunction-Associated Steatotic Liver Disease",
        "Metabolic Dysfunction-Associated Steatohepatitis",
        "MASLD",
        "MASH",
        "Weight Loss",
        "Insulin Resistance",
        "Insulin Sensitivity",
        "Insulin Sensitivity/Resistance",
        "Metabolic Disease",
        "Diabetes",
        "Diabetes Mellitus, Type 2",
        "NASH With Fibrosis",
        "Non-Alcoholic Fatty Liver Disease",
        "Non Alcoholic Fatty Liver",
        "Non-alcoholic Steatohepatitis"
      ],
      "interventions": [
        {
          "name": "ESG + lifestyle modification",
          "type": "DEVICE"
        },
        {
          "name": "Lifestyle modification",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "BEHAVIORAL"
      ],
      "sponsor": "Pichamol Jirapinyo, MD, MPH",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 132,
      "start_date": "2025-06-24",
      "completion_date": "2028-06",
      "has_results": false,
      "last_update_posted_date": "2026-06-25",
      "last_synced_at": "2026-09-29T21:34:04.242Z",
      "location_count": 2,
      "location_summary": "Boston, Massachusetts • Morgantown, West Virginia",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Morgantown",
          "state": "West Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06138821"
    }
  ]
}