{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Intracranial+CNS+Disorder&page=53",
    "query": {
      "condition": "Intracranial CNS Disorder",
      "page": 53
    },
    "page_size": 10
  },
  "pagination": {
    "page": 53,
    "page_size": 10,
    "total_count": 13355,
    "total_pages": 1336,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Intracranial+CNS+Disorder&page=54&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Intracranial+CNS+Disorder&page=52&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-11-04T01:48:16.506Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04595513",
      "title": "Stopping TSC Onset and Progression 2: Epilepsy Prevention in TSC Infants",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Tuberous Sclerosis Complex",
        "Epilepsy"
      ],
      "interventions": [
        {
          "name": "TAVT-18 (sirolimus)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Children's Hospital Medical Center, Cincinnati",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Day",
        "maximum_age": "6 Months",
        "sex": "ALL",
        "summary": "1 Day to 6 Months"
      },
      "enrollment_count": 5,
      "start_date": "2020-09-08",
      "completion_date": "2022-12-15",
      "has_results": true,
      "last_update_posted_date": "2024-05-16",
      "last_synced_at": "2026-11-04T01:48:16.506Z",
      "location_count": 1,
      "location_summary": "Cincinnati, Ohio",
      "locations": [
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04595513"
    },
    {
      "nct_id": "NCT00300924",
      "title": "A Study of Rizatriptan Co-Administered With Acetaminophen for the Treatment of Acute Migraine",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Migraine"
      ],
      "interventions": [
        {
          "name": "Rizatriptan co-administered with Acetaminophen",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Diamond Headache Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 200,
      "start_date": "2006-03",
      "completion_date": "2007-01",
      "has_results": false,
      "last_update_posted_date": "2008-05-28",
      "last_synced_at": "2026-11-04T01:48:16.506Z",
      "location_count": 7,
      "location_summary": "San Francisco, California • Chicago, Illinois • Kalamazoo, Michigan + 4 more",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Kalamazoo",
          "state": "Michigan"
        },
        {
          "city": "Springfield",
          "state": "Missouri"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00300924"
    },
    {
      "nct_id": "NCT00312559",
      "title": "The Therapeutics Effects of Yoga in Individuals With Parkinson's Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Parkinson's Disease"
      ],
      "interventions": [
        {
          "name": "Yoga Training",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Kansas",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 18,
      "start_date": "2006-02",
      "completion_date": "2007-03",
      "has_results": false,
      "last_update_posted_date": "2007-08-20",
      "last_synced_at": "2026-11-04T01:48:16.506Z",
      "location_count": 1,
      "location_summary": "Kansas City, Kansas",
      "locations": [
        {
          "city": "Kansas City",
          "state": "Kansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00312559"
    },
    {
      "nct_id": "NCT07444580",
      "title": "PrP-targeting siRNA Safety & Mechanism Study",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Prion Disease"
      ],
      "interventions": [
        {
          "name": "PrP-siRNA",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Broad Institute of MIT and Harvard",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 45,
      "start_date": "2026-05-15",
      "completion_date": "2029-08-14",
      "has_results": false,
      "last_update_posted_date": "2026-10-16",
      "last_synced_at": "2026-11-04T01:48:16.506Z",
      "location_count": 5,
      "location_summary": "Boston, Massachusetts • Rochester, Minnesota • New York, New York + 2 more",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07444580"
    },
    {
      "nct_id": "NCT01386580",
      "title": "An Open-label, Phase I/IIa, Dose Escalating Study of 2B3-101 in Patients With Solid Tumors and Brain Metastases or Recurrent Malignant Glioma.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Brain Metastases",
        "Lung Cancer",
        "Breast Cancer",
        "Melanoma",
        "Malignant Glioma"
      ],
      "interventions": [
        {
          "name": "2B3-101",
          "type": "DRUG"
        },
        {
          "name": "Trastuzumab",
          "type": "DRUG"
        },
        {
          "name": "2B3-101 60 mg/m2 every 4 weeks",
          "type": "DRUG"
        },
        {
          "name": "2B3-101 50 mg/m2 every 3 weeks",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "BBB-Therapeutics B.V.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 84,
      "start_date": "2011-07",
      "completion_date": "2014-12",
      "has_results": false,
      "last_update_posted_date": "2015-01-22",
      "last_synced_at": "2026-11-04T01:48:16.506Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01386580"
    },
    {
      "nct_id": "NCT05565703",
      "title": "The Use of PARO to Decrease Agitation in Persons With Dementia and/or Delirium",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dementia",
        "Delirium"
      ],
      "interventions": [
        {
          "name": "PARO Robotic Seal Intervention",
          "type": "OTHER"
        },
        {
          "name": "Attention Control",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": "110 Years",
        "sex": "ALL",
        "summary": "60 Years to 110 Years"
      },
      "enrollment_count": 104,
      "start_date": "2018-10-30",
      "completion_date": "2023-10-30",
      "has_results": false,
      "last_update_posted_date": "2024-06-10",
      "last_synced_at": "2026-11-04T01:48:16.506Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05565703"
    },
    {
      "nct_id": "NCT00904683",
      "title": "Effect of LY2062430 on the Progression of Alzheimer's Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Alzheimer's Disease"
      ],
      "interventions": [
        {
          "name": "LY2062430",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Eli Lilly and Company",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "55 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "55 Years and older"
      },
      "enrollment_count": 1040,
      "start_date": "2009-05",
      "completion_date": "2012-06",
      "has_results": false,
      "last_update_posted_date": "2012-12-13",
      "last_synced_at": "2026-11-04T01:48:16.506Z",
      "location_count": 16,
      "location_summary": "Tucson, Arizona • Los Angeles, California • San Diego, California + 13 more",
      "locations": [
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Santa Monica",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00904683"
    },
    {
      "nct_id": "NCT02840279",
      "title": "A Multiple Ascending Dose Study of BPN14770 in Healthy Young and Elderly Male or Female Subjects",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Alzheimer's Disease"
      ],
      "interventions": [
        {
          "name": "BPN14770",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Tetra Discovery Partners",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "25 Years to 90 Years"
      },
      "enrollment_count": 77,
      "start_date": "2016-06",
      "completion_date": "2016-12",
      "has_results": false,
      "last_update_posted_date": "2017-01-18",
      "last_synced_at": "2026-11-04T01:48:16.506Z",
      "location_count": 1,
      "location_summary": "Kalamazoo, Michigan",
      "locations": [
        {
          "city": "Kalamazoo",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02840279"
    },
    {
      "nct_id": "NCT05860127",
      "title": "Cognitive Stimulation Therapy for Dementia: A Two-Armed Pragmatic Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dementia",
        "Cognitive Impairment, Mild",
        "Dementia, Vascular",
        "Dementia, Mixed",
        "Dementia With Lewy Bodies",
        "Dementia Frontal",
        "Dementia Moderate",
        "Dementia of Alzheimer Type",
        "Dementia, Mild"
      ],
      "interventions": [
        {
          "name": "Referral for Cognitive Stimulation Therapy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "No change to Standard of Care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "University of Massachusetts, Amherst",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 133,
      "start_date": "2023-04-10",
      "completion_date": "2025-06-12",
      "has_results": true,
      "last_update_posted_date": "2026-03-23",
      "last_synced_at": "2026-11-04T01:48:16.506Z",
      "location_count": 2,
      "location_summary": "Farmington, Connecticut • New Haven, Connecticut",
      "locations": [
        {
          "city": "Farmington",
          "state": "Connecticut"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05860127"
    },
    {
      "nct_id": "NCT04575727",
      "title": "Exploratory Evaluation of [11C]MPC6827",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Neurodegenerative Diseases",
        "Alzheimer Disease",
        "Amyotrophic Lateral Sclerosis"
      ],
      "interventions": [
        {
          "name": "[11C]MPC6827",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Columbia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 17,
      "start_date": "2021-01-08",
      "completion_date": "2024-06-21",
      "has_results": false,
      "last_update_posted_date": "2025-04-13",
      "last_synced_at": "2026-11-04T01:48:16.506Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04575727"
    }
  ]
}