{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Irregular+Sleep-Wake+Rhythm+Disorder",
    "query": {
      "condition": "Irregular Sleep-Wake Rhythm Disorder"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 4,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T03:07:06.256Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03001557",
      "title": "Study of Lemborexant for Irregular Sleep-Wake Rhythm Disorder and Mild to Moderate Alzheimer's Disease Dementia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Irregular Sleep-Wake Rhythm Disorder"
      ],
      "interventions": [
        {
          "name": "Lemborexant 2.5 mg",
          "type": "DRUG"
        },
        {
          "name": "Lemborexant 5 mg",
          "type": "DRUG"
        },
        {
          "name": "Lemborexant 10 mg",
          "type": "DRUG"
        },
        {
          "name": "Lemborexant 15 mg",
          "type": "DRUG"
        },
        {
          "name": "Lemborexant-matched placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Eisai Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "60 Years to 90 Years"
      },
      "enrollment_count": 63,
      "start_date": "2016-12-20",
      "completion_date": "2020-04-17",
      "has_results": true,
      "last_update_posted_date": "2021-05-17",
      "last_synced_at": "2026-05-22T03:07:06.256Z",
      "location_count": 37,
      "location_summary": "Little Rock, Arkansas • Rogers, Arkansas • Costa Mesa, California + 30 more",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Rogers",
          "state": "Arkansas"
        },
        {
          "city": "Costa Mesa",
          "state": "California"
        },
        {
          "city": "Fullerton",
          "state": "California"
        },
        {
          "city": "Glendale",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03001557"
    },
    {
      "nct_id": "NCT03980340",
      "title": "Breath Biomarkers for Sleep Loss and Circadian Timing",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Shift-Work Sleep Disorder",
        "Shift Work Type Circadian Rhythm Sleep Disorder",
        "Sleep Disorders, Circadian Rhythm",
        "Sleep Disorders, Intrinsic",
        "Advanced Sleep Phase Syndrome (ASPS)",
        "Advanced Sleep Phase Syndrome",
        "Advanced Sleep Phase",
        "Delayed Sleep Phase",
        "Delayed Sleep Phase Syndrome",
        "Non-24 Hour Sleep-Wake Disorder",
        "Irregular Sleep-Wake Syndrome"
      ],
      "interventions": [
        {
          "name": "Short Nap Intervention",
          "type": "BEHAVIORAL"
        },
        {
          "name": "No Nap Intervention",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Brigham and Women's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 5,
      "start_date": "2021-01-28",
      "completion_date": "2025-03-31",
      "has_results": false,
      "last_update_posted_date": "2025-08-03",
      "last_synced_at": "2026-05-22T03:07:06.256Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03980340"
    },
    {
      "nct_id": "NCT04300569",
      "title": "A Study to Determine the Signs and Symptoms That Impact Daily Life of Participants With Irregular Sleep-Wake Rhythm Disorder",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Irregular Sleep Wake Rhythm Disorder"
      ],
      "interventions": [
        {
          "name": "Non-interventional",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Eisai Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 37,
      "start_date": "2020-07-09",
      "completion_date": "2020-09-07",
      "has_results": false,
      "last_update_posted_date": "2020-10-27",
      "last_synced_at": "2026-05-22T03:07:06.256Z",
      "location_count": 6,
      "location_summary": "Costa Mesa, California • San Diego, California • Miami, Florida + 3 more",
      "locations": [
        {
          "city": "Costa Mesa",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Miami Lakes",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04300569"
    },
    {
      "nct_id": "NCT03956745",
      "title": "Biomarkers for Circadian Timing in Healthy Adults",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Sleep Wake Disorders",
        "Sleep Disorders, Circadian Rhythm",
        "Sleep Disorders, Intrinsic",
        "Advanced Sleep Phase Syndrome (ASPS)",
        "Advanced Sleep Phase Syndrome",
        "Advanced Sleep Phase",
        "Delayed Sleep Phase",
        "Delayed Sleep Phase Syndrome",
        "Non-24 Hour Sleep-Wake Disorder",
        "Irregular Sleep-Wake Syndrome",
        "Shift-Work Sleep Disorder",
        "Shift Work Type Circadian Rhythm Sleep Disorder",
        "Delayed Phase Sleep Syndrome"
      ],
      "interventions": [
        {
          "name": "sleep-wake timing",
          "type": "BEHAVIORAL"
        },
        {
          "name": "constant routine",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Brigham and Women's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 15,
      "start_date": "2021-06-01",
      "completion_date": "2025-04-30",
      "has_results": false,
      "last_update_posted_date": "2025-08-03",
      "last_synced_at": "2026-05-22T03:07:06.256Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03956745"
    }
  ]
}