{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Joint+Instability",
    "query": {
      "condition": "Joint Instability"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 37,
    "total_pages": 4,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Joint+Instability&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T05:36:50.246Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00601471",
      "title": "Effects of Proximal and Distal Tibiofibular Joint Manipulation on Lower Extremity Muscle Activation, Ankle Range of Motion, and Functional Outcome Scores in Individuals With Chronic Ankle Instability",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ankle Sprain",
        "Ankle Injuries",
        "Sprain"
      ],
      "interventions": [
        {
          "name": "proximal tibiofibular manipulation",
          "type": "OTHER"
        },
        {
          "name": "distal tibiofibular manipulation",
          "type": "OTHER"
        },
        {
          "name": "no intervention",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Virginia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 61,
      "start_date": "2007-04",
      "completion_date": "2010-01",
      "has_results": false,
      "last_update_posted_date": "2010-06-24",
      "last_synced_at": "2026-05-22T05:36:50.246Z",
      "location_count": 1,
      "location_summary": "Charlottesville, Virginia",
      "locations": [
        {
          "city": "Charlottesville",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00601471"
    },
    {
      "nct_id": "NCT04697004",
      "title": "SMR Stemless Reverse Vs SMR Reverse Shoulder System",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Arthroplasty, Replacement"
      ],
      "interventions": [
        {
          "name": "Investigational Arm: SMR Stemless Reverse",
          "type": "DEVICE"
        },
        {
          "name": "Control Arm: SMR Reverse Shoulder System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Limacorporate S.p.a",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "22 Years and older"
      },
      "enrollment_count": 200,
      "start_date": "2021-04-01",
      "completion_date": "2026-03-30",
      "has_results": false,
      "last_update_posted_date": "2024-10-02",
      "last_synced_at": "2026-05-22T05:36:50.246Z",
      "location_count": 11,
      "location_summary": "Los Angeles, California • Denver, Colorado • Boca Raton, Florida + 7 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Boca Raton",
          "state": "Florida"
        },
        {
          "city": "Orlando",
          "state": "Florida"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04697004"
    },
    {
      "nct_id": "NCT00526266",
      "title": "Evaluating Physiological Markers of Emotional Trauma: A Randomized Controlled Comparison of Mind-Body Therapies",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypermobility, Joint",
        "Depression",
        "Anxiety"
      ],
      "interventions": [
        {
          "name": "Emotional Freedom Techniques (EFT)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Diaphragmatic Breathing (DB)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Soul Medicine Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 37,
      "start_date": "2007-09",
      "completion_date": "2018-01",
      "has_results": false,
      "last_update_posted_date": "2018-04-25",
      "last_synced_at": "2026-05-22T05:36:50.246Z",
      "location_count": 1,
      "location_summary": "Santa Rosa, California",
      "locations": [
        {
          "city": "Santa Rosa",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00526266"
    },
    {
      "nct_id": "NCT04176562",
      "title": "Prospective SPINE Registry",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Sacroiliac; Fusion",
        "Sacroiliac",
        "Joint Diseases",
        "Musculoskeletal Diseases",
        "Spinal Disease",
        "Spinal Stenosis",
        "Spinal Instability",
        "Fusion of Joint",
        "Fusion of Spine",
        "Spinal Fusion",
        "Spine"
      ],
      "interventions": [
        {
          "name": "RTI Spine products",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Xtant Medical",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 5000,
      "start_date": "2020-01-28",
      "completion_date": "2025-06",
      "has_results": false,
      "last_update_posted_date": "2024-03-12",
      "last_synced_at": "2026-05-22T05:36:50.246Z",
      "location_count": 7,
      "location_summary": "Hartford, Connecticut • Boca Raton, Florida • Delray Beach, Florida + 4 more",
      "locations": [
        {
          "city": "Hartford",
          "state": "Connecticut"
        },
        {
          "city": "Boca Raton",
          "state": "Florida"
        },
        {
          "city": "Delray Beach",
          "state": "Florida"
        },
        {
          "city": "Bartlett",
          "state": "Illinois"
        },
        {
          "city": "Carmel",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04176562"
    },
    {
      "nct_id": "NCT06883396",
      "title": "JUPITER 4.0 - Risk Factors for Failure of Isolated Medial Patellofemoral Ligament Reconstruction",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Patellar Dislocation, Recurrent",
        "Patellar Dislocation",
        "Patellar Instability",
        "Patellofemoral Dislocation",
        "Patellofemoral Joint Dislocation",
        "Patellofemoral Disorder"
      ],
      "interventions": [
        {
          "name": "Medial Patellofemoral Ligament (MPFL) Reconstruction",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Hospital for Special Surgery, New York",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "10 Years to 35 Years"
      },
      "enrollment_count": 850,
      "start_date": "2023-01-01",
      "completion_date": "2027-12",
      "has_results": false,
      "last_update_posted_date": "2026-02-13",
      "last_synced_at": "2026-05-22T05:36:50.246Z",
      "location_count": 16,
      "location_summary": "Redwood City, California • Gainesville, Florida • Chicago, Illinois + 10 more",
      "locations": [
        {
          "city": "Redwood City",
          "state": "California"
        },
        {
          "city": "Gainesville",
          "state": "Florida"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Iowa City",
          "state": "Iowa"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06883396"
    },
    {
      "nct_id": "NCT04302961",
      "title": "Effects of Gait Retraining With Auditory Feedback",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Ankle Injuries",
        "Ankle Inversion Sprain"
      ],
      "interventions": [
        {
          "name": "Auditory Feedback",
          "type": "OTHER"
        },
        {
          "name": "No Feedback",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of North Carolina, Charlotte",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 28,
      "start_date": "2020-10-05",
      "completion_date": "2021-06-30",
      "has_results": false,
      "last_update_posted_date": "2024-08-19",
      "last_synced_at": "2026-05-22T05:36:50.246Z",
      "location_count": 1,
      "location_summary": "Charlotte, North Carolina",
      "locations": [
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04302961"
    },
    {
      "nct_id": "NCT06556992",
      "title": "Fitness Integrative Training for Pediatric Rheumatology Disorders",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Juvenile Idiopathic Arthritis",
        "Systemic Lupus Erythematosus of Childhood",
        "Joint Hypermobility",
        "Juvenile Dermatomyositis"
      ],
      "interventions": [
        {
          "name": "FIT Teens",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Children's Hospital Medical Center, Cincinnati",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "19 Years",
        "sex": "ALL",
        "summary": "10 Years to 19 Years"
      },
      "enrollment_count": 10,
      "start_date": "2024-09-24",
      "completion_date": "2025-07-02",
      "has_results": false,
      "last_update_posted_date": "2025-08-28",
      "last_synced_at": "2026-05-22T05:36:50.246Z",
      "location_count": 1,
      "location_summary": "Cincinnati, Ohio",
      "locations": [
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06556992"
    },
    {
      "nct_id": "NCT01438905",
      "title": "Effect of Joint Mobilization in the Treatment of Chronic Ankle Instability",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ankle Sprain"
      ],
      "interventions": [
        {
          "name": "Small amplitude (Grade IV) mobilization",
          "type": "OTHER"
        },
        {
          "name": "High velocity, low amplitude (Grade V) mobilization",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Creighton University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": "45 Years",
        "sex": "MALE",
        "summary": "19 Years to 45 Years · Male only"
      },
      "enrollment_count": 30,
      "start_date": "2011-09",
      "completion_date": "2012-12",
      "has_results": false,
      "last_update_posted_date": "2018-02-23",
      "last_synced_at": "2026-05-22T05:36:50.246Z",
      "location_count": 1,
      "location_summary": "Omaha, Nebraska",
      "locations": [
        {
          "city": "Omaha",
          "state": "Nebraska"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01438905"
    },
    {
      "nct_id": "NCT03747198",
      "title": "Methylsulfonylmethane on Knee Laxity",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ligament Injury",
        "Ligament; Laxity",
        "Tendon Rupture",
        "Tendon Injuries"
      ],
      "interventions": [
        {
          "name": "methylsulfonylmethane",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "OTHER"
      ],
      "sponsor": "University of California, Davis",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "30 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 30 Years · Female only"
      },
      "enrollment_count": 32,
      "start_date": "2019-02-01",
      "completion_date": "2019-10-01",
      "has_results": false,
      "last_update_posted_date": "2020-06-01",
      "last_synced_at": "2026-05-22T05:36:50.246Z",
      "location_count": 1,
      "location_summary": "Davis, California",
      "locations": [
        {
          "city": "Davis",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03747198"
    },
    {
      "nct_id": "NCT00689962",
      "title": "A Comparison of Steel and Bioabsorbable Screw Fixation of Lisfranc Foot Injuries",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Joint Instability"
      ],
      "interventions": [
        {
          "name": "Linvatec 4.5 mm Smart Screw",
          "type": "DEVICE"
        },
        {
          "name": "Synthes 4.0 mm steel screw",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Rothman Institute Orthopaedics",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 50,
      "start_date": "2008-07",
      "completion_date": "2016-07",
      "has_results": false,
      "last_update_posted_date": "2017-01-18",
      "last_synced_at": "2026-05-22T05:36:50.246Z",
      "location_count": 2,
      "location_summary": "Media, Pennsylvania • Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Media",
          "state": "Pennsylvania"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00689962"
    }
  ]
}