{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Knee+Fracture",
    "query": {
      "condition": "Knee Fracture"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 42,
    "total_pages": 5,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Knee+Fracture&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T05:38:58.900Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05082831",
      "title": "Human ECM Implanted Within Microfracture Interstices & the Cartilage Defect in the Knee to Regenerate Hyaline Cartilage",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Articular Cartilage Disorder of Knee",
        "Cartilage Damage",
        "Microfractures"
      ],
      "interventions": [
        {
          "name": "microfracture surgery + HST003",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Histogen",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 1,
      "start_date": "2021-11-15",
      "completion_date": "2023-01-16",
      "has_results": false,
      "last_update_posted_date": "2023-01-19",
      "last_synced_at": "2026-05-22T05:38:58.900Z",
      "location_count": 5,
      "location_summary": "Vail, Colorado • Bradenton, Florida • Bethesda, Maryland + 2 more",
      "locations": [
        {
          "city": "Vail",
          "state": "Colorado"
        },
        {
          "city": "Bradenton",
          "state": "Florida"
        },
        {
          "city": "Bethesda",
          "state": "Maryland"
        },
        {
          "city": "State College",
          "state": "Pennsylvania"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05082831"
    },
    {
      "nct_id": "NCT01799876",
      "title": "Use of Cell Therapy to Enhance Arthroscopic Knee Cartilage Surgery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Articular Cartilage Defect Grade III or IV of the Knee"
      ],
      "interventions": [
        {
          "name": "Autologous Cell",
          "type": "PROCEDURE"
        },
        {
          "name": "Standard microfracture arthroscopic surgery",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Fondren Orthopedic Group L.L.P.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "68 Years",
        "sex": "ALL",
        "summary": "18 Years to 68 Years"
      },
      "enrollment_count": 48,
      "start_date": "2013-02",
      "completion_date": "2017-08",
      "has_results": false,
      "last_update_posted_date": "2019-01-10",
      "last_synced_at": "2026-05-22T05:38:58.900Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01799876"
    },
    {
      "nct_id": "NCT05037812",
      "title": "Role of Multimodal Analgesia in Decreasing Perioperative Pain in Tibial Plateau Fractures",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Tibial Plateau Fractures"
      ],
      "interventions": [
        {
          "name": "Saline injection",
          "type": "DRUG"
        },
        {
          "name": "Multimodal injections",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Utah",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "79 Years",
        "sex": "ALL",
        "summary": "18 Years to 79 Years"
      },
      "enrollment_count": 150,
      "start_date": "2019-03-25",
      "completion_date": "2028-03",
      "has_results": false,
      "last_update_posted_date": "2026-04-29",
      "last_synced_at": "2026-05-22T05:38:58.900Z",
      "location_count": 1,
      "location_summary": "Salt Lake City, Utah",
      "locations": [
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05037812"
    },
    {
      "nct_id": "NCT02168959",
      "title": "Continuous Femoral Nerve Block With a Tibial Plateau Fracture",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Tibial Plateau Fracture"
      ],
      "interventions": [
        {
          "name": "bupivacaine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Utah",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 5,
      "start_date": "2013-02",
      "completion_date": "2014-12",
      "has_results": false,
      "last_update_posted_date": "2016-03-14",
      "last_synced_at": "2026-05-22T05:38:58.900Z",
      "location_count": 1,
      "location_summary": "Salt Lake City, Utah",
      "locations": [
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02168959"
    },
    {
      "nct_id": "NCT06078371",
      "title": "Opioid-Free Pain Treatment in Trauma Patients",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Femoral Neck Fractures",
        "Intertrochanteric Fractures",
        "Femoral Shaft Fracture",
        "Distal Femur Fracture",
        "Patella Fracture",
        "Tibial Shaft Fracture with or Without Associated Fibula Fracture",
        "Ankle Fracture (bimalleolar Equivalent, Bimalleolar, or Trimalleolar)",
        "Tibial Pilon Fracture",
        "Talar Head, Neck, Body, or Process Fractures",
        "Calcaneus Fractures",
        "Lisfranc Injuries",
        "Isolated or Multiple Metatarsal Fractures",
        "Phalanx Fractures of the Foot, Single or Multiple",
        "Clavicle Fractures",
        "Proximal Humerus Fractures",
        "Humeral Shaft Fractures",
        "Distal Humerus Fractures (intra or Extra-articular)",
        "Olecranon Fractures",
        "Radial Head or Neck Fractures",
        "Elbow Fractures Involving a Combination of Fractures of the Radius and Uln",
        "Forearm Fractures (both Bone Forearm Fractures, Isolated Ulnar Shaft, Isolated Radial Shaft)",
        "Distal Radius Fractures"
      ],
      "interventions": [
        {
          "name": "Opioid-free pain treatment",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Kansas Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 250,
      "start_date": "2023-11-01",
      "completion_date": "2026-10",
      "has_results": false,
      "last_update_posted_date": "2024-10-26",
      "last_synced_at": "2026-05-22T05:38:58.900Z",
      "location_count": 1,
      "location_summary": "Kansas City, Kansas",
      "locations": [
        {
          "city": "Kansas City",
          "state": "Kansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06078371"
    },
    {
      "nct_id": "NCT06883396",
      "title": "JUPITER 4.0 - Risk Factors for Failure of Isolated Medial Patellofemoral Ligament Reconstruction",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Patellar Dislocation, Recurrent",
        "Patellar Dislocation",
        "Patellar Instability",
        "Patellofemoral Dislocation",
        "Patellofemoral Joint Dislocation",
        "Patellofemoral Disorder"
      ],
      "interventions": [
        {
          "name": "Medial Patellofemoral Ligament (MPFL) Reconstruction",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Hospital for Special Surgery, New York",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "10 Years to 35 Years"
      },
      "enrollment_count": 850,
      "start_date": "2023-01-01",
      "completion_date": "2027-12",
      "has_results": false,
      "last_update_posted_date": "2026-02-13",
      "last_synced_at": "2026-05-22T05:38:58.900Z",
      "location_count": 16,
      "location_summary": "Redwood City, California • Gainesville, Florida • Chicago, Illinois + 10 more",
      "locations": [
        {
          "city": "Redwood City",
          "state": "California"
        },
        {
          "city": "Gainesville",
          "state": "Florida"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Iowa City",
          "state": "Iowa"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06883396"
    },
    {
      "nct_id": "NCT05521958",
      "title": "Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tibial Shaft Fracture",
        "Tibial Plateau Fracture"
      ],
      "interventions": [
        {
          "name": "Acute injury without compartment syndrome",
          "type": "PROCEDURE"
        },
        {
          "name": "Acute injury with compartment syndrome",
          "type": "PROCEDURE"
        },
        {
          "name": "Exertional compartment syndrome",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Utah",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 80,
      "start_date": "2022-06-10",
      "completion_date": "2028-06",
      "has_results": false,
      "last_update_posted_date": "2026-04-29",
      "last_synced_at": "2026-05-22T05:38:58.900Z",
      "location_count": 1,
      "location_summary": "Salt Lake City, Utah",
      "locations": [
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05521958"
    },
    {
      "nct_id": "NCT04537013",
      "title": "Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Knee Injuries",
        "Cartilage Injury",
        "Cartilage Disease",
        "Knee Discomfort"
      ],
      "interventions": [
        {
          "name": "Microfracture",
          "type": "PROCEDURE"
        },
        {
          "name": "Microfracture plus placement of Chondro-Gide® ACC",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DEVICE"
      ],
      "sponsor": "Geistlich Pharma AG",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 82,
      "start_date": "2020-08-26",
      "completion_date": "2025-09-29",
      "has_results": false,
      "last_update_posted_date": "2026-02-13",
      "last_synced_at": "2026-05-22T05:38:58.900Z",
      "location_count": 3,
      "location_summary": "Phoenix, Arizona • Stamford, Connecticut • Johns Creek, Georgia",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Stamford",
          "state": "Connecticut"
        },
        {
          "city": "Johns Creek",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04537013"
    },
    {
      "nct_id": "NCT05060900",
      "title": "Hand Ligament Reconstructions With Knee Collateral Ligament Allografts",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hand Injuries",
        "Wrist Injuries",
        "Ligament Injury",
        "Ligament Rupture",
        "Ligament Avulsion"
      ],
      "interventions": [
        {
          "name": "Ligament Reconstruction with Allograft Ligament",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Cedars-Sinai Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 45,
      "start_date": "2021-09",
      "completion_date": "2023-09",
      "has_results": false,
      "last_update_posted_date": "2021-09-29",
      "last_synced_at": "2026-05-22T05:38:58.900Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05060900"
    },
    {
      "nct_id": "NCT00393848",
      "title": "Effectiveness of Two Types of Treatment in Restoring Muscle After Hip or Knee Surgery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Hip Fracture",
        "Osteoarthritis",
        "Femur Head Necrosis"
      ],
      "interventions": [
        {
          "name": "Essential amino acid supplement",
          "type": "DRUG"
        },
        {
          "name": "Ketoconazole",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Arkansas",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "30 Years to 80 Years"
      },
      "enrollment_count": 40,
      "start_date": "2006-10",
      "completion_date": "2012-10",
      "has_results": true,
      "last_update_posted_date": "2014-06-02",
      "last_synced_at": "2026-05-22T05:38:58.900Z",
      "location_count": 1,
      "location_summary": "Little Rock, Arkansas",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00393848"
    }
  ]
}