{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lacrimal+Apparatus+Disease&page=14", "query": { "condition": "Lacrimal Apparatus Disease", "page": 14 }, "page_size": 10 }, "pagination": { "page": 14, "page_size": 10, "total_count": 643, "total_pages": 65, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lacrimal+Apparatus+Disease&page=15&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lacrimal+Apparatus+Disease&page=13&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-15T16:45:09.798Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03968731", "title": "Meibomian Gland Dysfunction Management With ZEST Protocol", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Meibomian Gland Dysfunction", "Dry Eye Syndromes", "Ocular Surface Disease" ], "interventions": [ { "name": "Zocular Eyelid System Treatment", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "University of the Incarnate Word", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "21 Years", "maximum_age": null, "sex": "ALL", "summary": "21 Years and older" }, "enrollment_count": 30, "start_date": "2019-06-10", "completion_date": "2020-05-31", "has_results": false, "last_update_posted_date": "2022-07-14", "last_synced_at": "2026-10-15T16:45:09.798Z", "location_count": 1, "location_summary": "San Antonio, Texas", "locations": [ { "city": "San Antonio", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT03968731" }, { "nct_id": "NCT00784719", "title": "A Prospective, Randomized, Placebo and Active Comparator Controlled Study of CP-690,550 in Subjects With Dry Eye.", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Dry Eye Syndromes" ], "interventions": [ { "name": "CP-690,550", "type": "DRUG" }, { "name": "Cyclosporine", "type": "DRUG" }, { "name": "CP-690,550 Vehicle", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 327, "start_date": "2008-11", "completion_date": "2009-10", "has_results": true, "last_update_posted_date": "2013-04-09", "last_synced_at": "2026-10-15T16:45:09.798Z", "location_count": 27, "location_summary": "Chandler, Arizona • Peoria, Arizona • Phoenix, Arizona + 22 more", "locations": [ { "city": "Chandler", "state": "Arizona" }, { "city": "Peoria", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Artesia", "state": "California" }, { "city": "Centennial", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT00784719" }, { "nct_id": "NCT03682809", "title": "Evaluation of Systane Complete for the Treatment of Contact Lens Discomfort", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Contact Lens Discomfort", "Dry Eye" ], "interventions": [ { "name": "Systane Complete", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Alabama at Birmingham", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 46, "start_date": "2018-11-19", "completion_date": "2019-03-23", "has_results": true, "last_update_posted_date": "2020-04-06", "last_synced_at": "2026-10-15T16:45:09.798Z", "location_count": 3, "location_summary": "Birmingham, Alabama • Babylon, New York • Memphis, Tennessee", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Babylon", "state": "New York" }, { "city": "Memphis", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT03682809" }, { "nct_id": "NCT07161011", "title": "Phase 2b Controlled Study of Dosing Techniques - Part B", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Dry Eye" ], "interventions": [ { "name": "IVW-1001 Ophthalmic Eyelid Wipe 0.2%", "type": "DRUG" }, { "name": "IVW-1001 Ophthalmic Eyelid Wipe 0.4%", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "IVIEW Therapeutics Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 15, "start_date": "2025-09-08", "completion_date": "2025-11-03", "has_results": false, "last_update_posted_date": "2026-03-27", "last_synced_at": "2026-10-15T16:45:09.798Z", "location_count": 1, "location_summary": "Newport Beach, California", "locations": [ { "city": "Newport Beach", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT07161011" }, { "nct_id": "NCT01931644", "title": "At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "All Diagnosed Health Conditions", "ADD/ADHD", "Alopecia Areata", "Ankylosing Spondylitis", "Asthma", "Atopic Dermatitis Eczema", "Beta Thalassemia", "Bipolar Disorder", "Breast Cancer", "Celiac Disease", "Cervical Cancer", "Chronic Inflammatory Demyelinating Polyneuropathy", "Chronic Kidney Diseases", "Chronic Obstructive Pulmonary Disease", "Colon Cancer", "Colorectal Cancer", "Crohn's Disease", "Cystic Fibrosis", "Depression", "Diabetes Mellitus", "Duchenne Muscular Dystrophy", "Endometriosis", "Epilepsy", "Facioscapulohumeral Muscular Dystrophy", "G6PD Deficiency", "General Anxiety Disorder", "Hepatitis B", "Hereditary Hemorrhagic Telangiectasia", "HIV/AIDS", "Human Papilloma Virus", "Huntington's Disease", "Idiopathic Thrombocytopenic Purpura", "Insomnia", "Kidney Cancer", "Leukemia", "Lung Cancer", "Lupus Nephritis", "Lymphoma", "Melanoma", "Multiple Myeloma", "Multiple Sclerosis", "Myositis", "Myotonic Dystrophy", "Ovarian Cancer", "Pancreatic Cancer", "Parkinson's Disease", "Polycystic Kidney Diseases", "Prostate Cancer", "Psoriasis", "Psoriatic Arthritis", "Rosacea", "Scleroderma", "Sickle Cell Anemia", "Sickle Cell Trait", "Sjogren's Syndrome", "Skin Cancer", "Spinal Muscular Atrophy", "Systemic Lupus Erythematosus", "Thrombotic Thrombocytopenic Purpura", "Trisomy 21", "Ulcerative Colitis" ], "interventions": [], "intervention_types": [], "sponsor": "Sanguine Biosciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "100 Years", "sex": "ALL", "summary": "18 Years to 100 Years" }, "enrollment_count": 17667, "start_date": "2013-07", "completion_date": "2024-04", "has_results": false, "last_update_posted_date": "2024-04-18", "last_synced_at": "2026-10-15T16:45:09.798Z", "location_count": 1, "location_summary": "Los Angeles, California", "locations": [ { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01931644" }, { "nct_id": "NCT03006978", "title": "A Pilot Study of the TearCare System in Adults With Dry Eye Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dry Eye" ], "interventions": [ { "name": "TearCare", "type": "DEVICE" }, { "name": "Warm Compress", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Sight Sciences, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 24, "start_date": "2017-01", "completion_date": "2018-03", "has_results": true, "last_update_posted_date": "2025-10-15", "last_synced_at": "2026-10-15T16:45:09.798Z", "location_count": 1, "location_summary": "Arlington Heights, Illinois", "locations": [ { "city": "Arlington Heights", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT03006978" }, { "nct_id": "NCT04839315", "title": "COVID-19 Vaccination in Rheumatic Disease Patients", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Systemic Lupus Erythematosus", "Sjogren's Syndrome", "Inflammatory Myositis", "Psoriatic Arthritis", "Gout", "Ankylosing Spondylitis", "Arthritis of Multiple Sites Associated With Inflammatory Bowel Disease (Diagnosis)", "Osteoarthritis" ], "interventions": [ { "name": "mRNA COVD19 vaccine", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Mayo Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 58, "start_date": "2021-02-15", "completion_date": "2022-02-09", "has_results": false, "last_update_posted_date": "2022-06-03", "last_synced_at": "2026-10-15T16:45:09.798Z", "location_count": 1, "location_summary": "Rochester, Minnesota", "locations": [ { "city": "Rochester", "state": "Minnesota" } ], "official_url": "https://clinicaltrials.gov/study/NCT04839315" }, { "nct_id": "NCT04734197", "title": "A Research Study To See How Well an Eye Drop, SURF-100 (A Mycophenolic Acid/Betamethasone Sodium Phosphate Combination), Works and What Side Effects There Are in Subjects With Dry Eye Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Dry Eye Disease" ], "interventions": [ { "name": "SURF-100 (Combination of 0.3% Mycophenolic Acid and 0.01% Betamethasone Sodium Phosphate)", "type": "DRUG" }, { "name": "Mycophenolic Acid 0.1%", "type": "DRUG" }, { "name": "Mycophenolic Acid 0.3%", "type": "DRUG" }, { "name": "Betamethasone Sodium Phosphate 0.01%", "type": "DRUG" }, { "name": "Placebo Comparator: Vehicle", "type": "DRUG" }, { "name": "Cyclosporine 0.05% Ophthalmic Emulsion", "type": "DRUG" }, { "name": "Lifitegrast 5% Ophthalmic Solution", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Surface Ophthalmics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 349, "start_date": "2021-01-11", "completion_date": "2022-03-25", "has_results": true, "last_update_posted_date": "2025-05-11", "last_synced_at": "2026-10-15T16:45:09.798Z", "location_count": 40, "location_summary": "Phoenix, Arizona • Azusa, California • Hemet, California + 33 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Azusa", "state": "California" }, { "city": "Hemet", "state": "California" }, { "city": "Mission Hills", "state": "California" }, { "city": "Murrieta", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04734197" }, { "nct_id": "NCT03404115", "title": "A Multi-Center, Randomized, Double Masked, Parallel-Group, Vehicle-Controlled, Clinical Study to Assess the Safety and Efficacy of Reproxalap Ophthalmic Solution in Subjects With Dry Eye Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Dry Eye Syndrome" ], "interventions": [ { "name": "Reproxalap Ophthalmic Solution (0.25%)", "type": "DRUG" }, { "name": "Reproxalap Ophthalmic Solution (0.1%)", "type": "DRUG" }, { "name": "Vehicle Ophthalmic Solution", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Aldeyra Therapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 300, "start_date": "2018-01-02", "completion_date": "2018-07-11", "has_results": true, "last_update_posted_date": "2025-02-06", "last_synced_at": "2026-10-15T16:45:09.798Z", "location_count": 6, "location_summary": "Waterbury, Connecticut • Indianapolis, Indiana • Lewiston, Maine + 3 more", "locations": [ { "city": "Waterbury", "state": "Connecticut" }, { "city": "Indianapolis", "state": "Indiana" }, { "city": "Lewiston", "state": "Maine" }, { "city": "Andover", "state": "Massachusetts" }, { "city": "Raynham", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT03404115" }, { "nct_id": "NCT03688802", "title": "Efficacy of OC-01 Nasal Spray on Goblet Cell and Meibomian Gland Stimulation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Dry Eye Disease" ], "interventions": [ { "name": "OC-01 (varenicline) nasal spray", "type": "DRUG" }, { "name": "Placebo (vehicle control) nasal spray", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Oyster Point Pharma, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 18, "start_date": "2018-09-25", "completion_date": "2019-09-30", "has_results": true, "last_update_posted_date": "2021-12-29", "last_synced_at": "2026-10-15T16:45:09.798Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT03688802" } ] }