{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lacrimal+Apparatus+Disease&page=27", "query": { "condition": "Lacrimal Apparatus Disease", "page": 27 }, "page_size": 10 }, "pagination": { "page": 27, "page_size": 10, "total_count": 643, "total_pages": 65, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lacrimal+Apparatus+Disease&page=28&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lacrimal+Apparatus+Disease&page=26&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-16T17:06:37.800Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT04125134", "title": "Predicting the Success of Dry Eye Disease Interventions Using Clinical Tests", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Dry Eye" ], "interventions": [ { "name": "Preservative-free Refresh Optive Advanced Lubricant Eye Drops", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Tufts Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 36, "start_date": "2019-10-03", "completion_date": "2025-07-31", "has_results": false, "last_update_posted_date": "2025-09-22", "last_synced_at": "2026-10-16T17:06:37.800Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT04125134" }, { "nct_id": "NCT01206244", "title": "Diurnal Variation of Tear Meniscus and Tear Osmolarity", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Dry Eye" ], "interventions": [], "intervention_types": [], "sponsor": "University of Miami", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 20, "start_date": "2010-09", "completion_date": "2011-09", "has_results": false, "last_update_posted_date": "2013-06-13", "last_synced_at": "2026-10-16T17:06:37.800Z", "location_count": 1, "location_summary": "Miami, Florida", "locations": [ { "city": "Miami", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01206244" }, { "nct_id": "NCT04229771", "title": "Does Topical Ophthalmic Anesthetic Prior to Probing and Irrigation Decrease Pain?", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Epiphora", "Dacryostenosis", "Dacryocystitis" ], "interventions": [ { "name": "Proparacaine Hydrochloride ophthalmic solution, USP 0.5%", "type": "DRUG" }, { "name": "Balanced salt solution", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Corewell Health East", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 2, "start_date": "2020-06-30", "completion_date": "2020-11-30", "has_results": true, "last_update_posted_date": "2023-01-19", "last_synced_at": "2026-10-16T17:06:37.800Z", "location_count": 1, "location_summary": "Royal Oak, Michigan", "locations": [ { "city": "Royal Oak", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT04229771" }, { "nct_id": "NCT04201574", "title": "Phase 1/2a Safety and Efficacy of ALY688 Ophthalmic Solution in Subjects With Dry Eye Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Dry Eye Disease" ], "interventions": [ { "name": "ALY688 0.1%", "type": "DRUG" }, { "name": "ALY688 0.4%", "type": "DRUG" }, { "name": "Vehicle", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Allysta Pharmaceutical", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 138, "start_date": "2019-12-16", "completion_date": "2020-09-15", "has_results": true, "last_update_posted_date": "2023-06-22", "last_synced_at": "2026-10-16T17:06:37.800Z", "location_count": 1, "location_summary": "Bellevue, Washington", "locations": [ { "city": "Bellevue", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT04201574" }, { "nct_id": "NCT07732582", "title": "Sjogren's Mini-Pill Oral and Gut Microbiome Study", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Sjogren's Syndrome" ], "interventions": [ { "name": "Mini-Pill", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Tufts University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 90, "start_date": "2026-08-31", "completion_date": "2028-08-31", "has_results": false, "last_update_posted_date": "2026-07-29", "last_synced_at": "2026-10-16T17:06:37.800Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT07732582" }, { "nct_id": "NCT05148507", "title": "Optimization of the Ocular Surface Prior to Cataract Surgery Using PROKERA", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Cataract", "Dry Eye Syndromes", "Cataract Senile", "Dry Eye" ], "interventions": [ { "name": "PROKERA", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Jeff Wongskhaluang", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "100 Years", "sex": "ALL", "summary": "18 Years to 100 Years" }, "enrollment_count": 43, "start_date": "2021-11-04", "completion_date": "2025-01-21", "has_results": false, "last_update_posted_date": "2025-03-11", "last_synced_at": "2026-10-16T17:06:37.800Z", "location_count": 1, "location_summary": "Olathe, Kansas", "locations": [ { "city": "Olathe", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT05148507" }, { "nct_id": "NCT00799682", "title": "Exploratory Study Comparing Signs and Symptoms in Patients With Ocular Hypertension or Glaucoma Using Xalatan R® or Travatan Z®", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Dry Eye Disease" ], "interventions": [ { "name": "Xalatan", "type": "DRUG" }, { "name": "Travatan Z", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Ophthalmic Consultants of Long Island", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 56, "start_date": "2008-10", "completion_date": "2011-02", "has_results": false, "last_update_posted_date": "2011-07-21", "last_synced_at": "2026-10-16T17:06:37.800Z", "location_count": 5, "location_summary": "East Meadow, New York • Lynbrook, New York • Rockville Centre, New York + 2 more", "locations": [ { "city": "East Meadow", "state": "New York" }, { "city": "Lynbrook", "state": "New York" }, { "city": "Rockville Centre", "state": "New York" }, { "city": "Stony Brook", "state": "New York" }, { "city": "Valley Stream", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT00799682" }, { "nct_id": "NCT02193490", "title": "DNase Treatment for Dry Eyes", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Dry Eye" ], "interventions": [ { "name": "DNase", "type": "DRUG" }, { "name": "Vehicle", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Illinois at Chicago", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 47, "start_date": "2014-07", "completion_date": "2017-10-11", "has_results": true, "last_update_posted_date": "2020-01-18", "last_synced_at": "2026-10-16T17:06:37.800Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT02193490" }, { "nct_id": "NCT00048685", "title": "Study of Oral Bacteria in Patients With Dry Mouth", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Xerostomia", "Autoimmune Diseases" ], "interventions": [], "intervention_types": [], "sponsor": "National Institute of Dental and Craniofacial Research (NIDCR)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 44, "start_date": "2002-11", "completion_date": "2004-08", "has_results": false, "last_update_posted_date": "2008-03-04", "last_synced_at": "2026-10-16T17:06:37.800Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00048685" }, { "nct_id": "NCT04899518", "title": "ALY688 Ophthalmic Solution in Subjects With Dry Eye Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Dry Eye" ], "interventions": [ { "name": "ALY688 Ophthalmic Solution", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Allysta Pharmaceutical", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 922, "start_date": "2021-05-19", "completion_date": "2023-03-14", "has_results": false, "last_update_posted_date": "2023-03-16", "last_synced_at": "2026-10-16T17:06:37.800Z", "location_count": 1, "location_summary": "Bellevue, Washington", "locations": [ { "city": "Bellevue", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT04899518" } ] }