{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Limb+Amputation",
    "query": {
      "condition": "Limb Amputation"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 286,
    "total_pages": 29,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Limb+Amputation&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T16:20:23.468Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06638723",
      "title": "Enhancing Motor Function in Individuals with Lower Limb Amputation",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amputation"
      ],
      "interventions": [
        {
          "name": "Balance and fall recovery training",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Nevada, Las Vegas",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2023-06-30",
      "completion_date": "2025-12-31",
      "has_results": false,
      "last_update_posted_date": "2024-10-15",
      "last_synced_at": "2026-07-22T16:20:23.468Z",
      "location_count": 1,
      "location_summary": "Las Vegas, Nevada",
      "locations": [
        {
          "city": "Las Vegas",
          "state": "Nevada"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06638723"
    },
    {
      "nct_id": "NCT06419920",
      "title": "Prosthetic Performance Enhancement Trial",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amputation",
        "Lower Limb Amputation Below Knee (Injury)",
        "Lower Limb Amputation Above Knee (Injury)",
        "Lower Limb Amputation at Ankle (Injury)",
        "Lower Limb Amputation Knee",
        "Lower Limb Amputation at Hip (Injury)"
      ],
      "interventions": [
        {
          "name": "Flat terrain locomotor training",
          "type": "OTHER"
        },
        {
          "name": "Uneven terrain locomotor training",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Nevada, Las Vegas",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 35,
      "start_date": "2025-06-26",
      "completion_date": "2027-07",
      "has_results": false,
      "last_update_posted_date": "2026-06-23",
      "last_synced_at": "2026-07-22T16:20:23.468Z",
      "location_count": 1,
      "location_summary": "Las Vegas, Nevada",
      "locations": [
        {
          "city": "Las Vegas",
          "state": "Nevada"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06419920"
    },
    {
      "nct_id": "NCT06071715",
      "title": "Cryoanalgesia to Treat Phantom Limb Pain Following Above-Knee Amputation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amputation, Surgical",
        "Amputation, Traumatic",
        "Phantom Limb Pain",
        "Phantom Pain Following Amputation of Lower Limb"
      ],
      "interventions": [
        {
          "name": "ACTIVE cryoneurolysis",
          "type": "DEVICE"
        },
        {
          "name": "SHAM cryoneurolysis",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of California, San Diego",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 12,
      "start_date": "2024-02-12",
      "completion_date": "2025-10-09",
      "has_results": true,
      "last_update_posted_date": "2026-04-08",
      "last_synced_at": "2026-07-22T16:20:23.468Z",
      "location_count": 1,
      "location_summary": "La Jolla, California",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06071715"
    },
    {
      "nct_id": "NCT07204925",
      "title": "Towards Efficient Personalization of Computerized Lower Limb Prostheses Via Reinforcement Learning in a Clinical Setup - Group 1",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Transfemoral Amputation"
      ],
      "interventions": [
        {
          "name": "RISE guided personalization of prosthetic legs by tuning experts",
          "type": "DEVICE"
        },
        {
          "name": "RISE guided personalization of prosthetic legs by prosthetists",
          "type": "DEVICE"
        },
        {
          "name": "Manual personalization of the prosthetic leg by tuning experts",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "North Carolina State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 24,
      "start_date": "2025-08-01",
      "completion_date": "2029-11-01",
      "has_results": false,
      "last_update_posted_date": "2026-05-19",
      "last_synced_at": "2026-07-22T16:20:23.468Z",
      "location_count": 1,
      "location_summary": "Raleigh, North Carolina",
      "locations": [
        {
          "city": "Raleigh",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07204925"
    },
    {
      "nct_id": "NCT01606501",
      "title": "Outcomes Following Severe Distal Tibia, Ankle and/or Foot Trauma: Comparison of Limb Salvage Versus Transtibial Amputation Protocol",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Severe Distal Tibia Injury",
        "Severe Ankle Injury",
        "Severe Foot Injury",
        "Major Soft Tissue Loss",
        "Major Bone Articular Surface Loss",
        "Major Ankle Articular Surface Loss"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Major Extremity Trauma Research Consortium",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 664,
      "start_date": "2012-05",
      "completion_date": "2019-09-20",
      "has_results": false,
      "last_update_posted_date": "2021-03-24",
      "last_synced_at": "2026-07-22T16:20:23.468Z",
      "location_count": 33,
      "location_summary": "Birmingham, Alabama • San Diego, California • San Francisco, California + 26 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01606501"
    },
    {
      "nct_id": "NCT02165865",
      "title": "Vascularized Composite Allotransplantation of the Hand and Upper Extremity (Hand Transplant)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Traumatic Amputation of Arm",
        "Traumatic Amputation of Hand"
      ],
      "interventions": [
        {
          "name": "upper extremity/ hand transplantation",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Southern Illinois University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "69 Years",
        "sex": "ALL",
        "summary": "18 Years to 69 Years"
      },
      "enrollment_count": 2,
      "start_date": "2014-01",
      "completion_date": "2017-12",
      "has_results": false,
      "last_update_posted_date": "2019-07-02",
      "last_synced_at": "2026-07-22T16:20:23.468Z",
      "location_count": 3,
      "location_summary": "Springfield, Illinois",
      "locations": [
        {
          "city": "Springfield",
          "state": "Illinois"
        },
        {
          "city": "Springfield",
          "state": "Illinois"
        },
        {
          "city": "Springfield",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02165865"
    },
    {
      "nct_id": "NCT03260400",
      "title": "Short-term Implanted Electrodes Following Regenerative Peripheral Nerve Surgery for Improving Prosthetic Limb Control Signals",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amputation Neuroma",
        "Amputation"
      ],
      "interventions": [
        {
          "name": "a bipolar percutaneous intramuscular electromyography electrode",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "22 Years to 75 Years"
      },
      "enrollment_count": 10,
      "start_date": "2017-12-11",
      "completion_date": "2029-05-05",
      "has_results": false,
      "last_update_posted_date": "2025-08-26",
      "last_synced_at": "2026-07-22T16:20:23.468Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03260400"
    },
    {
      "nct_id": "NCT01967004",
      "title": "Enhancing Upper Limb Prostheses With Radio Frequency Identification",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Below Elbow Amputation"
      ],
      "interventions": [
        {
          "name": "Morph",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Infinite Biomedical Technologies",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 10,
      "start_date": "2013-08",
      "completion_date": "2014-06",
      "has_results": false,
      "last_update_posted_date": "2014-03-05",
      "last_synced_at": "2026-07-22T16:20:23.468Z",
      "location_count": 2,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01967004"
    },
    {
      "nct_id": "NCT01419288",
      "title": "Treadmill Training With Lower Extremity Amputees",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Traumatic Amputation of Lower Extremity"
      ],
      "interventions": [
        {
          "name": "Treadmill Training",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Stony Brook University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "21 Years to 70 Years"
      },
      "enrollment_count": 8,
      "start_date": "2009-06",
      "completion_date": "2012-06",
      "has_results": false,
      "last_update_posted_date": "2013-01-10",
      "last_synced_at": "2026-07-22T16:20:23.468Z",
      "location_count": 1,
      "location_summary": "Stony Brook, New York",
      "locations": [
        {
          "city": "Stony Brook",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01419288"
    },
    {
      "nct_id": "NCT05601869",
      "title": "Impact of Improving Footwear Options",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amputation"
      ],
      "interventions": [
        {
          "name": "RECOVER Prosthetic Ankle-Feet System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 18,
      "start_date": "2023-09-01",
      "completion_date": "2027-03-31",
      "has_results": false,
      "last_update_posted_date": "2026-04-07",
      "last_synced_at": "2026-07-22T16:20:23.468Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05601869"
    }
  ]
}