{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lower+Extremity&page=2",
    "query": {
      "condition": "Lower Extremity",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lower+Extremity&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-26T21:36:52.013Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05022121",
      "title": "Integrated Supported Biopsychosocial Self-Management for Back Related Leg Pain",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Low Back Pain",
        "Sciatica",
        "Back Related Leg Pain",
        "Pain, Chronic",
        "Intervertebral Disc Displacement"
      ],
      "interventions": [
        {
          "name": "Supported Biopsychosocial Self-Management (SBSM)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Medical Care",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 42,
      "start_date": "2022-01-26",
      "completion_date": "2023-02-20",
      "has_results": true,
      "last_update_posted_date": "2024-03-15",
      "last_synced_at": "2026-06-26T21:36:52.013Z",
      "location_count": 2,
      "location_summary": "Minneapolis, Minnesota • Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05022121"
    },
    {
      "nct_id": "NCT07444593",
      "title": "Transverse Tibial Bone Transport (TTT) in the Management of Chronic Diabetic Lower Extremity Wounds",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Diabetic Foot Ulcer",
        "Chronic Ulcers of the Lower Limb"
      ],
      "interventions": [
        {
          "name": "Biodynamik XT3",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Biodynamik, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "22 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2026-05-01",
      "completion_date": "2027-02-28",
      "has_results": false,
      "last_update_posted_date": "2026-04-27",
      "last_synced_at": "2026-06-26T21:36:52.013Z",
      "location_count": 1,
      "location_summary": "Jacksonville, Florida",
      "locations": [
        {
          "city": "Jacksonville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07444593"
    },
    {
      "nct_id": "NCT07172893",
      "title": "A Non-Randomized Open Label Clinical Trial Evaluating DermaBind TL",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Diabetic Foot Ulcer (DFU)",
        "Venous Leg Ulcer (VLU)"
      ],
      "interventions": [
        {
          "name": "DermaBind TL",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "HealthTech Wound Care",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 150,
      "start_date": "2025-12-10",
      "completion_date": "2027-05-21",
      "has_results": false,
      "last_update_posted_date": "2025-12-23",
      "last_synced_at": "2026-06-26T21:36:52.013Z",
      "location_count": 10,
      "location_summary": "DeLand, Florida • Palm Beach Gardens, Florida • Sweetwater, Florida + 7 more",
      "locations": [
        {
          "city": "DeLand",
          "state": "Florida"
        },
        {
          "city": "Palm Beach Gardens",
          "state": "Florida"
        },
        {
          "city": "Sweetwater",
          "state": "Florida"
        },
        {
          "city": "Bloomfield Township",
          "state": "Michigan"
        },
        {
          "city": "Cary",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07172893"
    },
    {
      "nct_id": "NCT04640584",
      "title": "C-Brace Prospective Registry",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Pareses",
        "Lower Extremity"
      ],
      "interventions": [
        {
          "name": "C-Brace",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Otto Bock Healthcare Products GmbH",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 250,
      "start_date": "2015-04",
      "completion_date": "2026-04",
      "has_results": false,
      "last_update_posted_date": "2025-04-30",
      "last_synced_at": "2026-06-26T21:36:52.013Z",
      "location_count": 70,
      "location_summary": "Harrison, Arkansas • Rogers, Arkansas • San Diego, California + 63 more",
      "locations": [
        {
          "city": "Harrison",
          "state": "Arkansas"
        },
        {
          "city": "Rogers",
          "state": "Arkansas"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Palm Harbor",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04640584"
    },
    {
      "nct_id": "NCT05273463",
      "title": "Comparing Perioperative Education Modalities for ACL Reconstruction on Patient Satisfaction, Self-Efficacy, and Surgical Outcomes",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "ACL Injury",
        "Anterior Cruciate Ligament Injuries"
      ],
      "interventions": [
        {
          "name": "Video-Based Intervention",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Classroom-Based Intervention",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "15 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "15 Years to 65 Years"
      },
      "enrollment_count": 105,
      "start_date": "2022-08-23",
      "completion_date": "2026-08-01",
      "has_results": false,
      "last_update_posted_date": "2026-04-13",
      "last_synced_at": "2026-06-26T21:36:52.013Z",
      "location_count": 1,
      "location_summary": "Phoenix, Arizona",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05273463"
    },
    {
      "nct_id": "NCT03927404",
      "title": "Development of Adaptive Vacuum Suspension to Improve Prosthetic Fit and Residual Limb Health",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Lower Limb Amputation"
      ],
      "interventions": [
        {
          "name": "Active vacuum test prosthesis",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 60,
      "start_date": "2020-02-12",
      "completion_date": "2021-09-06",
      "has_results": true,
      "last_update_posted_date": "2024-05-24",
      "last_synced_at": "2026-06-26T21:36:52.013Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03927404"
    },
    {
      "nct_id": "NCT05072652",
      "title": "Short Term Immobilization of the Lower Limb",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Weakness, Muscle",
        "Muscle Weakness",
        "Muscle Loss",
        "Muscle Atrophy",
        "Injury, Knee"
      ],
      "interventions": [
        {
          "name": "Neuromuscular Electrical Stimulation",
          "type": "OTHER"
        },
        {
          "name": "Action Observation + Mental Imagery",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Central Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 50,
      "start_date": "2021-10-11",
      "completion_date": "2022-07-01",
      "has_results": false,
      "last_update_posted_date": "2022-08-19",
      "last_synced_at": "2026-06-26T21:36:52.013Z",
      "location_count": 1,
      "location_summary": "Orlando, Florida",
      "locations": [
        {
          "city": "Orlando",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05072652"
    },
    {
      "nct_id": "NCT00680784",
      "title": "HKT-500 in Adult Patients With Ankle Sprain",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Ankle Sprain"
      ],
      "interventions": [
        {
          "name": "HKT-500 Ketoprofen Topical Patch",
          "type": "DRUG"
        },
        {
          "name": "Placebo Patch",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Hisamitsu Pharmaceutical Co., Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 260,
      "start_date": "2008-04",
      "completion_date": "2008-11",
      "has_results": false,
      "last_update_posted_date": "2015-06-04",
      "last_synced_at": "2026-06-26T21:36:52.013Z",
      "location_count": 30,
      "location_summary": "Birmingham, Alabama • Montgomery, Alabama • Anaheim, California + 26 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Montgomery",
          "state": "Alabama"
        },
        {
          "city": "Anaheim",
          "state": "California"
        },
        {
          "city": "San Luis Obispo",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00680784"
    },
    {
      "nct_id": "NCT01512121",
      "title": "Spinal Cord Stimulation and Functional MRI",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Complex Regional Pain Syndrome (CRPS)",
        "Neuropathic Leg Pain"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Vibhor Krishna",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 10,
      "start_date": "2011-09",
      "completion_date": "2017-08",
      "has_results": false,
      "last_update_posted_date": "2019-09-23",
      "last_synced_at": "2026-06-26T21:36:52.013Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01512121"
    },
    {
      "nct_id": "NCT04230512",
      "title": "Assessment of a Hybrid Pump for Vacuum Suspension of Prosthetic Sockets for Persons With Lower Limb Loss to Characterize the Effects of Added Movement on Socket-reaction Torques",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amputation"
      ],
      "interventions": [
        {
          "name": "Pump prototype",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 12,
      "start_date": "2020-04-04",
      "completion_date": "2026-03-31",
      "has_results": false,
      "last_update_posted_date": "2026-05-11",
      "last_synced_at": "2026-06-26T21:36:52.013Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04230512"
    }
  ]
}