{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lower+Extremity+Amputation&page=2",
    "query": {
      "condition": "Lower Extremity Amputation",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lower+Extremity+Amputation&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T06:46:10.597Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05915065",
      "title": "VR to Evaluate Phantom Limb Pain",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Phantom Limb Pain",
        "Phantom Pain",
        "Phantom Sensation",
        "Phantom Limb Syndrome With Pain",
        "Phantom Pain Following Amputation of Lower Limb",
        "Phantom Pain Following Amputation of Upper Limb",
        "Amputation",
        "Upper Limb Amputation at the Hand",
        "Upper Limb Amputation at the Wrist",
        "Upper Limb Amputation Below Elbow (Injury)",
        "Upper Limb Amputation Above Elbow (Injury)",
        "Lower Limb Amputation Knee",
        "Lower Limb Amputation Above Knee (Injury)",
        "Lower Limb Amputation Below Knee (Injury)",
        "Lower Limb Amputation at Ankle (Injury)"
      ],
      "interventions": [
        {
          "name": "Coapt Phantom Limb Pain Management System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Shirley Ryan AbilityLab",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 48,
      "start_date": "2020-10-01",
      "completion_date": "2025-09-30",
      "has_results": false,
      "last_update_posted_date": "2025-03-14",
      "last_synced_at": "2026-05-22T06:46:10.597Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05915065"
    },
    {
      "nct_id": "NCT05203471",
      "title": "Crossing the Divide: Piloting Integrated Care to Reduce Amputations Among Rural Patients With Diabetic Foot Ulcers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Diabetic Foot",
        "Diabetic Ulcer of Left Foot",
        "Diabetic Ulcer of Right Foot",
        "Amputation"
      ],
      "interventions": [
        {
          "name": "integrated care model",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 131,
      "start_date": "2023-02-16",
      "completion_date": "2025-06-25",
      "has_results": true,
      "last_update_posted_date": "2026-04-27",
      "last_synced_at": "2026-05-22T06:46:10.597Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05203471"
    },
    {
      "nct_id": "NCT02540681",
      "title": "Prosthetic Fit Assessment in Transtibial Amputees Secondary to Trauma",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Traumatic Amputation of Lower Extremity"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Major Extremity Trauma Research Consortium",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 33,
      "start_date": "2015-01",
      "completion_date": "2021-01",
      "has_results": false,
      "last_update_posted_date": "2021-03-24",
      "last_synced_at": "2026-05-22T06:46:10.597Z",
      "location_count": 10,
      "location_summary": "San Francisco, California • Tampa, Florida • Baltimore, Maryland + 7 more",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Jackson",
          "state": "Mississippi"
        },
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02540681"
    },
    {
      "nct_id": "NCT04275973",
      "title": "Evaluating Mobility Interventions in the Real World",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Lower Limb Amputation",
        "Drop Foot"
      ],
      "interventions": [
        {
          "name": "Lower limb prostheses",
          "type": "DEVICE"
        },
        {
          "name": "Orthoses for Drop-foot",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 20,
      "start_date": "2021-09-03",
      "completion_date": "2024-08-01",
      "has_results": true,
      "last_update_posted_date": "2025-12-19",
      "last_synced_at": "2026-05-22T06:46:10.597Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04275973"
    },
    {
      "nct_id": "NCT03970538",
      "title": "PROMISE II: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Critical Limb Ischemia",
        "Critical Lower Limb Ischemia",
        "Peripheral Artery Disease",
        "Peripheral Arterial Disease",
        "Chronic Limb-Threatening Ischemia",
        "Arterial Occlusive Diseases",
        "Arterial Occlusion",
        "Arterial Disease",
        "Peripheral Artery Occlusion",
        "Peripheral Vascular Disease",
        "Peripheral Ischemia",
        "Vascular Diseases"
      ],
      "interventions": [
        {
          "name": "LimFlow System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "LimFlow, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "95 Years",
        "sex": "ALL",
        "summary": "18 Years to 95 Years"
      },
      "enrollment_count": 105,
      "start_date": "2019-12-06",
      "completion_date": "2025-02-28",
      "has_results": true,
      "last_update_posted_date": "2024-02-28",
      "last_synced_at": "2026-05-22T06:46:10.597Z",
      "location_count": 20,
      "location_summary": "San Francisco, California • Torrance, California • New Haven, Connecticut + 15 more",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Torrance",
          "state": "California"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Gainesville",
          "state": "Florida"
        },
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03970538"
    },
    {
      "nct_id": "NCT03927404",
      "title": "Development of Adaptive Vacuum Suspension to Improve Prosthetic Fit and Residual Limb Health",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Lower Limb Amputation"
      ],
      "interventions": [
        {
          "name": "Active vacuum test prosthesis",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 60,
      "start_date": "2020-02-12",
      "completion_date": "2021-09-06",
      "has_results": true,
      "last_update_posted_date": "2024-05-24",
      "last_synced_at": "2026-05-22T06:46:10.597Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03927404"
    },
    {
      "nct_id": "NCT06071715",
      "title": "Cryoanalgesia to Treat Phantom Limb Pain Following Above-Knee Amputation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amputation, Surgical",
        "Amputation, Traumatic",
        "Phantom Limb Pain",
        "Phantom Pain Following Amputation of Lower Limb"
      ],
      "interventions": [
        {
          "name": "ACTIVE cryoneurolysis",
          "type": "DEVICE"
        },
        {
          "name": "SHAM cryoneurolysis",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of California, San Diego",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 12,
      "start_date": "2024-02-12",
      "completion_date": "2025-10-09",
      "has_results": true,
      "last_update_posted_date": "2026-04-08",
      "last_synced_at": "2026-05-22T06:46:10.597Z",
      "location_count": 1,
      "location_summary": "La Jolla, California",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06071715"
    },
    {
      "nct_id": "NCT04717557",
      "title": "Hyperbaric Oxygen and Outcome After Below Knee Amputations",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Amputation; Postoperative, Sequelae"
      ],
      "interventions": [
        {
          "name": "Hyperbaric Oxygen",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 4,
      "start_date": "2021-01-01",
      "completion_date": "2023-10-31",
      "has_results": true,
      "last_update_posted_date": "2025-08-11",
      "last_synced_at": "2026-05-22T06:46:10.597Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04717557"
    },
    {
      "nct_id": "NCT01225432",
      "title": "The Effect of Gait Training Using Virtual Reality and Real-Time Feedback on Physiological and Functional Gait Performance in Persons With a Traumatic Lower Extremity Amputation",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Elevated Metabolic Cost"
      ],
      "interventions": [
        {
          "name": "Gait Training",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Brooke Army Medical Center",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 66,
      "start_date": "2007-08",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2010-10-21",
      "last_synced_at": "2026-05-22T06:46:10.597Z",
      "location_count": 1,
      "location_summary": "Fort Sam Houston, Texas",
      "locations": [
        {
          "city": "Fort Sam Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01225432"
    },
    {
      "nct_id": "NCT02328859",
      "title": "Virtual Reality Rehabilitation for Individuals With Lower Limb Amputation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Transtibial Amputation"
      ],
      "interventions": [
        {
          "name": "Virtual Reality Gait Training",
          "type": "OTHER"
        },
        {
          "name": "Treadmill Gait Training",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 4,
      "start_date": "2016-04-01",
      "completion_date": "2017-06-27",
      "has_results": false,
      "last_update_posted_date": "2019-10-24",
      "last_synced_at": "2026-05-22T06:46:10.597Z",
      "location_count": 1,
      "location_summary": "Providence, Rhode Island",
      "locations": [
        {
          "city": "Providence",
          "state": "Rhode Island"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02328859"
    }
  ]
}