{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lower+Extremity+Musculoskeletal+Injury",
    "query": {
      "condition": "Lower Extremity Musculoskeletal Injury"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 131,
    "total_pages": 14,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lower+Extremity+Musculoskeletal+Injury&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T08:12:50.220Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06274021",
      "title": "Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Spinal Cord Injuries",
        "Spinal Cord Injury",
        "Spinal Cord Injury Cervical",
        "Spinal Cord Injury Thoracic"
      ],
      "interventions": [
        {
          "name": "Transcutaneous spinal stimulation at 100 Hz",
          "type": "DEVICE"
        },
        {
          "name": "Transcutaneous spinal stimulation at 50 Hz",
          "type": "DEVICE"
        },
        {
          "name": "Transcutaneous spinal stimulation at 50 Hz and single dose of baclofen",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Transcutaneous spinal stimulation at 50 Hz and single dose of tizanidine",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Sham transcutaneous spinal stimulation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "University of Mississippi Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 16,
      "start_date": "2024-03-01",
      "completion_date": "2025-12-31",
      "has_results": false,
      "last_update_posted_date": "2024-07-01",
      "last_synced_at": "2026-05-22T08:12:50.220Z",
      "location_count": 2,
      "location_summary": "Jackson, Mississippi",
      "locations": [
        {
          "city": "Jackson",
          "state": "Mississippi"
        },
        {
          "city": "Jackson",
          "state": "Mississippi"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06274021"
    },
    {
      "nct_id": "NCT06442956",
      "title": "Effect of Rapid Heat Stress on Firefighters Musculoskeletal Injury Risk",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Occupational Injuries",
        "Heat Stress",
        "Leg Injury",
        "Back Injuries"
      ],
      "interventions": [
        {
          "name": "Rapid Heat Condition",
          "type": "OTHER"
        },
        {
          "name": "Gradual Heat Condition",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Louisiana State University Health Sciences Center Shreveport",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "57 Years",
        "sex": "ALL",
        "summary": "18 Years to 57 Years"
      },
      "enrollment_count": 26,
      "start_date": "2025-01-07",
      "completion_date": "2025-11-07",
      "has_results": false,
      "last_update_posted_date": "2026-03-30",
      "last_synced_at": "2026-05-22T08:12:50.220Z",
      "location_count": 1,
      "location_summary": "Shreveport, Louisiana",
      "locations": [
        {
          "city": "Shreveport",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06442956"
    },
    {
      "nct_id": "NCT05456295",
      "title": "Comparative Effect of Carbon Fiber Orthosis Cuff Design on Preference, Comfort, and Mechanics",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Healthy",
        "Lower Limb Injury",
        "Post-Traumatic Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "Carbon Fiber Custom Dynamic Orthosis (CDO)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Iowa",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 35,
      "start_date": "2023-05-17",
      "completion_date": "2025-09-29",
      "has_results": false,
      "last_update_posted_date": "2026-01-15",
      "last_synced_at": "2026-05-22T08:12:50.220Z",
      "location_count": 1,
      "location_summary": "Iowa City, Iowa",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05456295"
    },
    {
      "nct_id": "NCT04270565",
      "title": "Gait-Training Using Wearable Sensors",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Shin Splint",
        "Running-related Injury"
      ],
      "interventions": [
        {
          "name": "In-Field Gait-Training",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Home Exercise",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Virginia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 20,
      "start_date": "2020-02-05",
      "completion_date": "2021-05-31",
      "has_results": false,
      "last_update_posted_date": "2022-05-18",
      "last_synced_at": "2026-05-22T08:12:50.220Z",
      "location_count": 1,
      "location_summary": "Charlottesville, Virginia",
      "locations": [
        {
          "city": "Charlottesville",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04270565"
    },
    {
      "nct_id": "NCT00434837",
      "title": "Initial Graft Tension and ACL Surgery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Anterior Cruciate Ligament Rupture"
      ],
      "interventions": [
        {
          "name": "Initial graft tension during ACL reconstruction surgery",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Rhode Island Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "15 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "15 Years to 50 Years"
      },
      "enrollment_count": 168,
      "start_date": "2004-02",
      "completion_date": "2024-02-29",
      "has_results": true,
      "last_update_posted_date": "2025-04-01",
      "last_synced_at": "2026-05-22T08:12:50.220Z",
      "location_count": 2,
      "location_summary": "Providence, Rhode Island",
      "locations": [
        {
          "city": "Providence",
          "state": "Rhode Island"
        },
        {
          "city": "Providence",
          "state": "Rhode Island"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00434837"
    },
    {
      "nct_id": "NCT05461326",
      "title": "Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Orthopedic Disorder",
        "Anterior Cruciate Ligament Injuries"
      ],
      "interventions": [
        {
          "name": "Quad tendon",
          "type": "PROCEDURE"
        },
        {
          "name": "BTB",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "14 Years to 65 Years"
      },
      "enrollment_count": 100,
      "start_date": "2023-09-26",
      "completion_date": "2030-06-30",
      "has_results": false,
      "last_update_posted_date": "2025-06-08",
      "last_synced_at": "2026-05-22T08:12:50.220Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05461326"
    },
    {
      "nct_id": "NCT00601341",
      "title": "Effects of Lumbosacral Joint Mobilization/Manipulation on Lower Extremity Muscle Neuromuscular Response",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Knee Pain",
        "Hip Pain",
        "Ankle Pain",
        "Lumbopelvic Pain"
      ],
      "interventions": [
        {
          "name": "lumbosacral joint manipulation",
          "type": "OTHER"
        },
        {
          "name": "lumbar passive range of motion",
          "type": "OTHER"
        },
        {
          "name": "No active intervention",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Virginia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 106,
      "start_date": "2005-05",
      "completion_date": "2009-11",
      "has_results": false,
      "last_update_posted_date": "2010-06-24",
      "last_synced_at": "2026-05-22T08:12:50.220Z",
      "location_count": 1,
      "location_summary": "Charlottesville, Virginia",
      "locations": [
        {
          "city": "Charlottesville",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00601341"
    },
    {
      "nct_id": "NCT01804894",
      "title": "Do Common Physical Tests Predict Injury or Performance",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Lower Extremity Musculoskeletal Injury"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "High Point University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "23 Years",
        "sex": "ALL",
        "summary": "18 Years to 23 Years"
      },
      "enrollment_count": 359,
      "start_date": "2013-03",
      "completion_date": "2015-03",
      "has_results": false,
      "last_update_posted_date": "2015-04-03",
      "last_synced_at": "2026-05-22T08:12:50.220Z",
      "location_count": 1,
      "location_summary": "High Point, North Carolina",
      "locations": [
        {
          "city": "High Point",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01804894"
    },
    {
      "nct_id": "NCT05144191",
      "title": "Insignia™ Hip Stem Outcomes Study",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hip Osteoarthritis",
        "Avascular Necrosis",
        "Rheumatoid Arthritis",
        "Post-traumatic Osteoarthritis",
        "Femoral Neck Fractures",
        "Trochanteric Fractures",
        "Surgery"
      ],
      "interventions": [
        {
          "name": "Insignia uncemented Hip Stem",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Stryker Orthopaedics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 313,
      "start_date": "2022-02-07",
      "completion_date": "2034-04-02",
      "has_results": false,
      "last_update_posted_date": "2026-05-18",
      "last_synced_at": "2026-05-22T08:12:50.220Z",
      "location_count": 11,
      "location_summary": "Phoenix, Arizona • San Francisco, California • Chicago, Illinois + 8 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Reno",
          "state": "Nevada"
        },
        {
          "city": "Great Neck",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05144191"
    },
    {
      "nct_id": "NCT03809520",
      "title": "An Imaging Framework for Clinically Testing New Treatments to Prevent Post-traumatic OA",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Orthopedic Disorder",
        "Trauma",
        "Ankle Fractures",
        "Post-traumatic Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "pedCAT",
          "type": "RADIATION"
        }
      ],
      "intervention_types": [
        "RADIATION"
      ],
      "sponsor": "J L Marsh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 97,
      "start_date": "2017-02-01",
      "completion_date": "2022-03-31",
      "has_results": true,
      "last_update_posted_date": "2026-04-24",
      "last_synced_at": "2026-05-22T08:12:50.220Z",
      "location_count": 1,
      "location_summary": "Iowa City, Iowa",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03809520"
    }
  ]
}