{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lower+Limb+Amputation&page=3",
    "query": {
      "condition": "Lower Limb Amputation",
      "page": 3
    },
    "page_size": 10
  },
  "pagination": {
    "page": 3,
    "page_size": 10,
    "total_count": 178,
    "total_pages": 18,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lower+Limb+Amputation&page=4&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lower+Limb+Amputation&page=2&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-11-15T08:13:33.150Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT07215442",
      "title": "Skin Temperature Perception and Prosthetic Thermoregulation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Lower Limb Amputation Below Knee",
        "Diabetes (DM)",
        "Skin Temperature Change",
        "Vascular Reactivity"
      ],
      "interventions": [
        {
          "name": "Warming stimulus starting at 30 C initial temperature",
          "type": "OTHER"
        },
        {
          "name": "Warming stimulus starting at 32 C initial temperature",
          "type": "OTHER"
        },
        {
          "name": "Warming stimulus starting at 34 C initial temperature",
          "type": "OTHER"
        },
        {
          "name": "Warming stimulus starting at 35 C initial temperature",
          "type": "OTHER"
        },
        {
          "name": "Cooling stimulus starting at 30 C initial temperature",
          "type": "OTHER"
        },
        {
          "name": "Cooling stimulus starting at 32 C initial temperature",
          "type": "OTHER"
        },
        {
          "name": "Cooling stimulus starting at 34 C initial temperature",
          "type": "OTHER"
        },
        {
          "name": "Cooling stimulus starting at 35 C initial temperature",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "VA Puget Sound Health Care System",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 56,
      "start_date": "2011-04-28",
      "completion_date": "2013-08-09",
      "has_results": false,
      "last_update_posted_date": "2025-10-10",
      "last_synced_at": "2026-11-15T08:13:33.150Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07215442"
    },
    {
      "nct_id": "NCT05915065",
      "title": "VR to Evaluate Phantom Limb Pain",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Phantom Limb Pain",
        "Phantom Pain",
        "Phantom Sensation",
        "Phantom Limb Syndrome With Pain",
        "Phantom Pain Following Amputation of Lower Limb",
        "Phantom Pain Following Amputation of Upper Limb",
        "Amputation",
        "Upper Limb Amputation at the Hand",
        "Upper Limb Amputation at the Wrist",
        "Upper Limb Amputation Below Elbow (Injury)",
        "Upper Limb Amputation Above Elbow (Injury)",
        "Lower Limb Amputation Knee",
        "Lower Limb Amputation Above Knee (Injury)",
        "Lower Limb Amputation Below Knee (Injury)",
        "Lower Limb Amputation at Ankle (Injury)"
      ],
      "interventions": [
        {
          "name": "Coapt Phantom Limb Pain Management System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Shirley Ryan AbilityLab",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 48,
      "start_date": "2020-10-01",
      "completion_date": "2025-09-30",
      "has_results": false,
      "last_update_posted_date": "2025-03-14",
      "last_synced_at": "2026-11-15T08:13:33.150Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05915065"
    },
    {
      "nct_id": "NCT00932399",
      "title": "Longitudinal Study of Weight Change Following Lower Limb Amputation",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Amputation Wound",
        "Traumatic Amputation of Toe",
        "Dysvascular Amputation of Lower Limb"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "27 Years",
        "maximum_age": "89 Years",
        "sex": "MALE",
        "summary": "27 Years to 89 Years · Male only"
      },
      "enrollment_count": 4549,
      "start_date": "2010-03",
      "completion_date": "2016-01",
      "has_results": true,
      "last_update_posted_date": "2016-02-08",
      "last_synced_at": "2026-11-15T08:13:33.150Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00932399"
    },
    {
      "nct_id": "NCT02341963",
      "title": "A Pilot Clinical Trial of Oral Ketamine for Acute Pain Management After Amputation Surgery",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Acute Pain Management",
        "Analgesic, Nonopioid",
        "Amputation of Lower Extremity, All Causes"
      ],
      "interventions": [
        {
          "name": "Oral Ketamine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Rush University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 5,
      "start_date": "2015-01",
      "completion_date": "2021-01",
      "has_results": false,
      "last_update_posted_date": "2021-03-01",
      "last_synced_at": "2026-11-15T08:13:33.150Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02341963"
    },
    {
      "nct_id": "NCT03532100",
      "title": "Pivot-Flex Foot: Optimal Coupling Ratio Between Transverse and Sagittal-plane Motions Using a Torsionally Adaptive Prosthesis for Individuals With Lower Limb Amputation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Lower Extremity Amputation"
      ],
      "interventions": [
        {
          "name": "Torsionally adaptive prosthesis with 0:1 coupling ratio",
          "type": "DEVICE"
        },
        {
          "name": "Torsionally adaptive prosthesis with 1:6 coupling ratio",
          "type": "DEVICE"
        },
        {
          "name": "Torsionally adaptive prosthesis with 1:4 coupling ratio",
          "type": "DEVICE"
        },
        {
          "name": "Torsionally adaptive prosthesis with 1:3 coupling ratio",
          "type": "DEVICE"
        },
        {
          "name": "Torsionally adaptive prosthesis with 1:2 coupling ratio",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 14,
      "start_date": "2018-04-18",
      "completion_date": "2024-11-18",
      "has_results": true,
      "last_update_posted_date": "2025-11-19",
      "last_synced_at": "2026-11-15T08:13:33.150Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03532100"
    },
    {
      "nct_id": "NCT01839123",
      "title": "Evaluation of Limb Health Associated With a Prosthetic Vacuum Socket System",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Lower Limb Amputation"
      ],
      "interventions": [
        {
          "name": "Prosthetic Suction or Pin Socket",
          "type": "DEVICE"
        },
        {
          "name": "Prosthetic LimbLogic Vacuum Socket",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Ohio Willow Wood",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 10,
      "start_date": "2013-04",
      "completion_date": "2014-09",
      "has_results": false,
      "last_update_posted_date": "2013-07-01",
      "last_synced_at": "2026-11-15T08:13:33.150Z",
      "location_count": 2,
      "location_summary": "Columbus, Ohio • Mount Sterling, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        },
        {
          "city": "Mount Sterling",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01839123"
    },
    {
      "nct_id": "NCT01293214",
      "title": "Vascularized Composite Allotransplantation for Multiple Extremity Amputations",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Limb Amputation",
        "Extremity Amputation"
      ],
      "interventions": [
        {
          "name": "Limb transplantation",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Brigham and Women's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 10,
      "start_date": "2010-02-01",
      "completion_date": "2030-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-10-01",
      "last_synced_at": "2026-11-15T08:13:33.150Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01293214"
    },
    {
      "nct_id": "NCT07024342",
      "title": "Optimizing Prosthetic Prescription to Mitigate the Effects of Perspiration",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amputation",
        "Prosthesis User"
      ],
      "interventions": [
        {
          "name": "Liner perforated with very small diameter holes",
          "type": "DEVICE"
        },
        {
          "name": "Liner perforated with somewhat larger diameter holes",
          "type": "DEVICE"
        },
        {
          "name": "Liner-liner",
          "type": "DEVICE"
        },
        {
          "name": "As-prescribed liner",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "VA Puget Sound Health Care System",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 180,
      "start_date": "2022-10-04",
      "completion_date": "2027-02",
      "has_results": false,
      "last_update_posted_date": "2026-09-28",
      "last_synced_at": "2026-11-15T08:13:33.150Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07024342"
    },
    {
      "nct_id": "NCT01606501",
      "title": "Outcomes Following Severe Distal Tibia, Ankle and/or Foot Trauma: Comparison of Limb Salvage Versus Transtibial Amputation Protocol",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Severe Distal Tibia Injury",
        "Severe Ankle Injury",
        "Severe Foot Injury",
        "Major Soft Tissue Loss",
        "Major Bone Articular Surface Loss",
        "Major Ankle Articular Surface Loss"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Major Extremity Trauma Research Consortium",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 664,
      "start_date": "2012-05",
      "completion_date": "2019-09-20",
      "has_results": false,
      "last_update_posted_date": "2021-03-24",
      "last_synced_at": "2026-11-15T08:13:33.150Z",
      "location_count": 33,
      "location_summary": "Birmingham, Alabama • San Diego, California • San Francisco, California + 26 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01606501"
    },
    {
      "nct_id": "NCT05880251",
      "title": "Operant Conditioning of Sensory Brain Responses to Reduce Phantom Limb Pain in People With Limb Amputation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Phantom Limb Pain After Amputation",
        "Lower Limb Amputation",
        "Upper Limb Amputation",
        "Phantom Pain",
        "Chronic Pain"
      ],
      "interventions": [
        {
          "name": "Operant Conditioning with Peripheral Stimulation",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Control Group with Peripheral Stimulation Only",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2023-07-01",
      "completion_date": "2025-08-29",
      "has_results": false,
      "last_update_posted_date": "2026-01-16",
      "last_synced_at": "2026-11-15T08:13:33.150Z",
      "location_count": 1,
      "location_summary": "Albany, New York",
      "locations": [
        {
          "city": "Albany",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05880251"
    }
  ]
}