{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lower+Limb+Amputation&page=7",
    "query": {
      "condition": "Lower Limb Amputation",
      "page": 7
    },
    "page_size": 10
  },
  "pagination": {
    "page": 7,
    "page_size": 10,
    "total_count": 178,
    "total_pages": 18,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lower+Limb+Amputation&page=8&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lower+Limb+Amputation&page=6&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-11-15T10:58:35.529Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06636136",
      "title": "Transtibial Osseointegration",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amputation; Traumatic, Leg, Lower"
      ],
      "interventions": [
        {
          "name": "OPRA",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Walter Reed National Military Medical Center",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "22 Years to 65 Years"
      },
      "enrollment_count": 30,
      "start_date": "2025-05-20",
      "completion_date": "2030-04-30",
      "has_results": false,
      "last_update_posted_date": "2026-10-13",
      "last_synced_at": "2026-11-15T10:58:35.529Z",
      "location_count": 2,
      "location_summary": "Bethesda, Maryland • Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06636136"
    },
    {
      "nct_id": "NCT05267639",
      "title": "Clinical Outcomes With Passive MPKs vs. Powered Prosthetic Knees",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amputation",
        "Amputation; Traumatic, Leg, Lower",
        "Limb; Absence, Congenital, Lower",
        "Prosthesis User",
        "Lower Limb Amputation Above Knee (Injury)",
        "Amputation; Traumatic, Leg: Thigh, Between Hip and Knee"
      ],
      "interventions": [
        {
          "name": "Power Knee",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Liberating Technologies, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 13,
      "start_date": "2022-05-01",
      "completion_date": "2024-08-28",
      "has_results": true,
      "last_update_posted_date": "2026-09-17",
      "last_synced_at": "2026-11-15T10:58:35.529Z",
      "location_count": 2,
      "location_summary": "Holliston, Massachusetts • Austin, Texas",
      "locations": [
        {
          "city": "Holliston",
          "state": "Massachusetts"
        },
        {
          "city": "Austin",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05267639"
    },
    {
      "nct_id": "NCT02540681",
      "title": "Prosthetic Fit Assessment in Transtibial Amputees Secondary to Trauma",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Traumatic Amputation of Lower Extremity"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Major Extremity Trauma Research Consortium",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 33,
      "start_date": "2015-01",
      "completion_date": "2021-01",
      "has_results": false,
      "last_update_posted_date": "2021-03-24",
      "last_synced_at": "2026-11-15T10:58:35.529Z",
      "location_count": 10,
      "location_summary": "San Francisco, California • Tampa, Florida • Baltimore, Maryland + 7 more",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Jackson",
          "state": "Mississippi"
        },
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02540681"
    },
    {
      "nct_id": "NCT02355912",
      "title": "Adaptive Recalibration of Prosthetic Leg Neural Control System",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amputation"
      ],
      "interventions": [
        {
          "name": "Powered knee and ankle prosthesis",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Shirley Ryan AbilityLab",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 22,
      "start_date": "2015-01",
      "completion_date": "2020-01",
      "has_results": false,
      "last_update_posted_date": "2020-10-28",
      "last_synced_at": "2026-11-15T10:58:35.529Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02355912"
    },
    {
      "nct_id": "NCT03411148",
      "title": "Targeting Balance Confidence to Increase Community Integration in Users of Prostheses",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amputation",
        "Physical Activity"
      ],
      "interventions": [
        {
          "name": "Weekly exercise sessions with physical therapist and psychologist",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Home-based exercises",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Rosalind Franklin University of Medicine and Science",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 22,
      "start_date": "2018-04-05",
      "completion_date": "2022-05-01",
      "has_results": false,
      "last_update_posted_date": "2022-06-01",
      "last_synced_at": "2026-11-15T10:58:35.529Z",
      "location_count": 2,
      "location_summary": "North Chicago, Illinois",
      "locations": [
        {
          "city": "North Chicago",
          "state": "Illinois"
        },
        {
          "city": "North Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03411148"
    },
    {
      "nct_id": "NCT04543786",
      "title": "Neuromodulation in Lower Limb Amputees",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amputation",
        "Phantom Limb Pain",
        "Hoffman's Reflex"
      ],
      "interventions": [
        {
          "name": "Transcutaneous spinal cord stimulation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "21 Years to 70 Years"
      },
      "enrollment_count": 3,
      "start_date": "2022-03-07",
      "completion_date": "2022-06-29",
      "has_results": true,
      "last_update_posted_date": "2023-07-24",
      "last_synced_at": "2026-11-15T10:58:35.529Z",
      "location_count": 2,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04543786"
    },
    {
      "nct_id": "NCT04070105",
      "title": "No Power Bionic Lower Extremity Prosthesis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amputation",
        "Amputation, Traumatic",
        "Amputation; Traumatic, Leg, Lower"
      ],
      "interventions": [
        {
          "name": "Compliant Adaptive Energy Storage and Return Foot",
          "type": "DEVICE"
        },
        {
          "name": "AllPro",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 6,
      "start_date": "2020-09-01",
      "completion_date": "2022-12-31",
      "has_results": true,
      "last_update_posted_date": "2024-03-27",
      "last_synced_at": "2026-11-15T10:58:35.529Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04070105"
    },
    {
      "nct_id": "NCT05471375",
      "title": "C-STAR Movement Database",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Stroke",
        "Parkinson Disease",
        "Lower Limb Amputation Above Knee (Injury)",
        "Lower Limb Amputation Below Knee (Injury)"
      ],
      "interventions": [
        {
          "name": "Database Entry",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Shirley Ryan AbilityLab",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "Up to 99 Years"
      },
      "enrollment_count": 250,
      "start_date": "2022-08-19",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-05-12",
      "last_synced_at": "2026-11-15T10:58:35.529Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05471375"
    },
    {
      "nct_id": "NCT02813161",
      "title": "The Diabetic Foot Ulcer Registry",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Diabetic Foot Ulcer Outcome",
        "Quality of Patient Care"
      ],
      "interventions": [
        {
          "name": "cellular and tissue based therapy",
          "type": "BIOLOGICAL"
        },
        {
          "name": "negative pressure wound therapy",
          "type": "DEVICE"
        },
        {
          "name": "debridement",
          "type": "PROCEDURE"
        },
        {
          "name": "advanced wound therapy",
          "type": "PROCEDURE"
        },
        {
          "name": "Nutritional screening",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "off-loading",
          "type": "DEVICE"
        },
        {
          "name": "Hyperbaric oxygen Therapy",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "DEVICE",
        "PROCEDURE",
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "U.S. Wound Registry",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 10000,
      "start_date": "2015-02",
      "completion_date": "2025-02",
      "has_results": false,
      "last_update_posted_date": "2018-05-03",
      "last_synced_at": "2026-11-15T10:58:35.529Z",
      "location_count": 1,
      "location_summary": "The Woodlands, Texas",
      "locations": [
        {
          "city": "The Woodlands",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02813161"
    },
    {
      "nct_id": "NCT07204925",
      "title": "Towards Efficient Personalization of Computerized Lower Limb Prostheses Via Reinforcement Learning in a Clinical Setup - Group 1",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Transfemoral Amputation"
      ],
      "interventions": [
        {
          "name": "RISE guided personalization of prosthetic legs by tuning experts",
          "type": "DEVICE"
        },
        {
          "name": "RISE guided personalization of prosthetic legs by prosthetists",
          "type": "DEVICE"
        },
        {
          "name": "Manual personalization of the prosthetic leg by tuning experts",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "North Carolina State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 24,
      "start_date": "2025-08-01",
      "completion_date": "2029-11-01",
      "has_results": false,
      "last_update_posted_date": "2026-05-19",
      "last_synced_at": "2026-11-15T10:58:35.529Z",
      "location_count": 1,
      "location_summary": "Raleigh, North Carolina",
      "locations": [
        {
          "city": "Raleigh",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07204925"
    }
  ]
}