{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lower+Limb+Spasticity", "query": { "condition": "Lower Limb Spasticity" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 30, "total_pages": 3, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lower+Limb+Spasticity&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-07-22T07:45:24.861Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01251367", "title": "Dysport® Adult Lower Limb Spasticity Follow-on Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Post-stroke Spasticity", "Spasticity Post-Traumatic Brain Injury" ], "interventions": [ { "name": "Botulinum toxin type A", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Ipsen", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 352, "start_date": "2011-06", "completion_date": "2015-04", "has_results": true, "last_update_posted_date": "2022-09-28", "last_synced_at": "2026-07-22T07:45:24.861Z", "location_count": 15, "location_summary": "Scottsdale, Arizona • Downey, California • Oxnard, California + 12 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Downey", "state": "California" }, { "city": "Oxnard", "state": "California" }, { "city": "Fairfield", "state": "Connecticut" }, { "city": "Miami", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01251367" }, { "nct_id": "NCT04437251", "title": "Effect of Brain Stimulation on Stepping Performance in Stroke Survivors and Healthy Adults", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Vascular Accident, Brain", "CVA (Cerebrovascular Accident)", "Gait, Hemiplegic", "Spastic Lower Extremity Weakness" ], "interventions": [ { "name": "Transcranial direct current stimulation (tDCS)", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Texas Woman's University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "21 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "21 Years to 90 Years" }, "enrollment_count": 180, "start_date": "2014-09-26", "completion_date": "2024-12-31", "has_results": false, "last_update_posted_date": "2020-06-18", "last_synced_at": "2026-07-22T07:45:24.861Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT04437251" }, { "nct_id": "NCT03585569", "title": "\" Treating MS Patients With Lower Extremity Spasticity Using Dysport\"", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Multiple Sclerosis", "Spasticity, Muscle" ], "interventions": [ { "name": "Abobotulinumtoxin A", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Neurology Center of New England P.C.", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 30, "start_date": "2018-05-01", "completion_date": "2020-05", "has_results": false, "last_update_posted_date": "2018-07-13", "last_synced_at": "2026-07-22T07:45:24.861Z", "location_count": 1, "location_summary": "Foxborough, Massachusetts", "locations": [ { "city": "Foxborough", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT03585569" }, { "nct_id": "NCT03017729", "title": "Effectiveness and Safety of Dysport® (abobotulinumtoxinA) in Paediatric Lower Limb Spasticity", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Lower Limb Spasticity" ], "interventions": [ { "name": "Botulinum toxin type A", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Ipsen", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "2 Years to 17 Years" }, "enrollment_count": 242, "start_date": "2017-02-10", "completion_date": "2020-11-30", "has_results": false, "last_update_posted_date": "2020-12-19", "last_synced_at": "2026-07-22T07:45:24.861Z", "location_count": 27, "location_summary": "Washington D.C., District of Columbia • Miami, Florida • North Palm Beach, Florida + 23 more", "locations": [ { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Miami", "state": "Florida" }, { "city": "North Palm Beach", "state": "Florida" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT03017729" }, { "nct_id": "NCT02699190", "title": "LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Leukodystrophy", "White Matter Disease", "4H Syndrome", "Adrenoleukodystrophy", "AMN", "ALD", "ALD (Adrenoleukodystrophy)", "X-linked Adrenoleukodystrophy", "X-ALD", "Adrenomyeloneuropathy", "Aicardi Goutieres Syndrome", "AGS", "Alexander Disease", "Alexanders Leukodystrophy", "AxD", "ADLD", "Canavan Disease", "CTX", "Cerebrotendinous Xanthomatoses", "Krabbe Disease", "GALC Deficiency", "Globoid Leukodystrophy", "TUBB4A-Related Leukodystrophy", "H-ABC - Hypomyelination, Atrophy of Basal Ganglia and Cerebellum", "HBSL", "HBSL - Hypomyelination, Brain Stem, Spinal Cord, Leg Spasticity", "LBSL", "Leukoencephalopathy With Brain Stem and Spinal Cord Involvement and High Lactate Syndrome (Disorder)", "Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation", "ALSP", "CSF1R Gene Mutation", "HCC - Hypomyelination and Congenital Cataract", "MLC1", "Megalencephalic Leukoencephalopathy With Subcortical Cysts 1", "MLD", "Metachromatic Leukodystrophy", "PMD", "Pelizaeus-Merzbacher Disease", "PLP1 Null Syndrome", "PLP1 Gene Duplication | Blood or Tissue | Mutations", "Pelizaeus-Merzbacher-Like Disease, 1", "Peroxisomal Biogenesis Disorder", "Zellweger Syndrome", "Refsum Disease", "Salla Disease", "Sialic Storage Disease", "Sjögren", "Sjogren-Larsson Syndrome", "Van Der Knapp Disease", "Vanishing White Matter Disease", "Charcot-Marie-Tooth", "CMT", "Mct8 (Slc16A2)-Specific Thyroid Hormone Cell Transporter Deficiency", "Allan-Herndon-Dudley Syndrome", "Cadasil", "Cockayne Syndrome", "Multiple Sulfatase Deficiency", "Gangliosidoses", "GM2 Gangliosidosis", "BPAN", "Labrune Syndrome", "LCC", "Mucopolysaccharidoses", "TBCK-Related Intellectual Disability Syndrome" ], "interventions": [], "intervention_types": [], "sponsor": "Children's Hospital of Philadelphia", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": "18 Years", "sex": "ALL", "summary": "Up to 18 Years" }, "enrollment_count": 236, "start_date": "2017-01-06", "completion_date": "2024-10-31", "has_results": true, "last_update_posted_date": "2025-11-10", "last_synced_at": "2026-07-22T07:45:24.861Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT02699190" }, { "nct_id": "NCT01249404", "title": "Dysport® Adult Lower Limb Spasticity Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Leg Spasticity" ], "interventions": [ { "name": "Botulinum toxin type A", "type": "BIOLOGICAL" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "Ipsen", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 388, "start_date": "2011-03", "completion_date": "2014-05", "has_results": true, "last_update_posted_date": "2022-09-28", "last_synced_at": "2026-07-22T07:45:24.861Z", "location_count": 17, "location_summary": "Scottsdale, Arizona • Downey, California • Oxnard, California + 12 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Downey", "state": "California" }, { "city": "Oxnard", "state": "California" }, { "city": "Fairfield", "state": "Connecticut" }, { "city": "Boca Raton", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01249404" }, { "nct_id": "NCT06274021", "title": "Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Spinal Cord Injuries", "Spinal Cord Injury", "Spinal Cord Injury Cervical", "Spinal Cord Injury Thoracic" ], "interventions": [ { "name": "Transcutaneous spinal stimulation at 100 Hz", "type": "DEVICE" }, { "name": "Transcutaneous spinal stimulation at 50 Hz", "type": "DEVICE" }, { "name": "Transcutaneous spinal stimulation at 50 Hz and single dose of baclofen", "type": "COMBINATION_PRODUCT" }, { "name": "Transcutaneous spinal stimulation at 50 Hz and single dose of tizanidine", "type": "COMBINATION_PRODUCT" }, { "name": "Sham transcutaneous spinal stimulation", "type": "DEVICE" } ], "intervention_types": [ "DEVICE", "COMBINATION_PRODUCT" ], "sponsor": "University of Mississippi Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 16, "start_date": "2024-03-01", "completion_date": "2025-12-31", "has_results": false, "last_update_posted_date": "2024-07-01", "last_synced_at": "2026-07-22T07:45:24.861Z", "location_count": 2, "location_summary": "Jackson, Mississippi", "locations": [ { "city": "Jackson", "state": "Mississippi" }, { "city": "Jackson", "state": "Mississippi" } ], "official_url": "https://clinicaltrials.gov/study/NCT06274021" }, { "nct_id": "NCT01603641", "title": "BOTOX® Open-Label Treatment in Pediatric Lower Limb Spasticity", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Pediatrics", "Muscle Spasticity", "Cerebral Palsy" ], "interventions": [ { "name": "Botulinum Toxin Type A", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Allergan", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "2 Years to 17 Years" }, "enrollment_count": 370, "start_date": "2012-11-05", "completion_date": "2018-08-25", "has_results": true, "last_update_posted_date": "2019-08-21", "last_synced_at": "2026-07-22T07:45:24.861Z", "location_count": 26, "location_summary": "Pasadena, California • Pomona, California • San Diego, California + 21 more", "locations": [ { "city": "Pasadena", "state": "California" }, { "city": "Pomona", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Fairfield", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT01603641" }, { "nct_id": "NCT01575054", "title": "BOTOX® Treatment in Adult Patients With Post-Stroke Lower Limb Spasticity", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Muscle Spasticity" ], "interventions": [ { "name": "botulinum toxin Type A", "type": "BIOLOGICAL" }, { "name": "Normal Saline", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "Allergan", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 468, "start_date": "2012-05", "completion_date": "2015-07", "has_results": true, "last_update_posted_date": "2016-09-28", "last_synced_at": "2026-07-22T07:45:24.861Z", "location_count": 2, "location_summary": "Downey, California • Daytona Beach, Florida", "locations": [ { "city": "Downey", "state": "California" }, { "city": "Daytona Beach", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01575054" }, { "nct_id": "NCT02002884", "title": "Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Arm(s) or of Arm(s) and Leg(s) in Cerebral Palsy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Cerebral Palsy", "Spasticity" ], "interventions": [ { "name": "IncobotulinumtoxinA (8 Units per kg body weight)", "type": "DRUG" }, { "name": "IncobotulinumtoxinA (6 Units per kg body weight)", "type": "DRUG" }, { "name": "IncobotulinumtoxinA (2 Units per kg body weight)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Merz Pharmaceuticals GmbH", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "2 Years to 17 Years" }, "enrollment_count": 351, "start_date": "2014-03-28", "completion_date": "2018-08-28", "has_results": true, "last_update_posted_date": "2021-08-05", "last_synced_at": "2026-07-22T07:45:24.861Z", "location_count": 6, "location_summary": "Gulf Breeze, Florida • Loxahatchee Groves, Florida • Savannah, Georgia + 3 more", "locations": [ { "city": "Gulf Breeze", "state": "Florida" }, { "city": "Loxahatchee Groves", "state": "Florida" }, { "city": "Savannah", "state": "Georgia" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Royal Oak", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT02002884" } ] }