{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lower+Limb+Spasticity&page=2",
    "query": {
      "condition": "Lower Limb Spasticity",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Lower+Limb+Spasticity&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T21:46:58.721Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02299284",
      "title": "Intensive Home-based Bimanual and Lower-limb Training in Young Children With Hemiplegia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cerebral Palsy"
      ],
      "interventions": [
        {
          "name": "Intensive Home-based Bimanual and Lower-limb Training in Young Children With Hemiplegia",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Teachers College, Columbia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Years",
        "maximum_age": "12 Years",
        "sex": "ALL",
        "summary": "2 Years to 12 Years"
      },
      "enrollment_count": 24,
      "start_date": "2013-06",
      "completion_date": "2015-06",
      "has_results": false,
      "last_update_posted_date": "2017-05-09",
      "last_synced_at": "2026-07-22T21:46:58.721Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02299284"
    },
    {
      "nct_id": "NCT01603641",
      "title": "BOTOX® Open-Label Treatment in Pediatric Lower Limb Spasticity",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Pediatrics",
        "Muscle Spasticity",
        "Cerebral Palsy"
      ],
      "interventions": [
        {
          "name": "Botulinum Toxin Type A",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Allergan",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "2 Years to 17 Years"
      },
      "enrollment_count": 370,
      "start_date": "2012-11-05",
      "completion_date": "2018-08-25",
      "has_results": true,
      "last_update_posted_date": "2019-08-21",
      "last_synced_at": "2026-07-22T21:46:58.721Z",
      "location_count": 26,
      "location_summary": "Pasadena, California • Pomona, California • San Diego, California + 21 more",
      "locations": [
        {
          "city": "Pasadena",
          "state": "California"
        },
        {
          "city": "Pomona",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Fairfield",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01603641"
    },
    {
      "nct_id": "NCT02002884",
      "title": "Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Arm(s) or of Arm(s) and Leg(s) in Cerebral Palsy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Cerebral Palsy",
        "Spasticity"
      ],
      "interventions": [
        {
          "name": "IncobotulinumtoxinA (8 Units per kg body weight)",
          "type": "DRUG"
        },
        {
          "name": "IncobotulinumtoxinA (6 Units per kg body weight)",
          "type": "DRUG"
        },
        {
          "name": "IncobotulinumtoxinA (2 Units per kg body weight)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Merz Pharmaceuticals GmbH",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "2 Years to 17 Years"
      },
      "enrollment_count": 351,
      "start_date": "2014-03-28",
      "completion_date": "2018-08-28",
      "has_results": true,
      "last_update_posted_date": "2021-08-05",
      "last_synced_at": "2026-07-22T21:46:58.721Z",
      "location_count": 6,
      "location_summary": "Gulf Breeze, Florida • Loxahatchee Groves, Florida • Savannah, Georgia + 3 more",
      "locations": [
        {
          "city": "Gulf Breeze",
          "state": "Florida"
        },
        {
          "city": "Loxahatchee Groves",
          "state": "Florida"
        },
        {
          "city": "Savannah",
          "state": "Georgia"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Royal Oak",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02002884"
    },
    {
      "nct_id": "NCT01251367",
      "title": "Dysport® Adult Lower Limb Spasticity Follow-on Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Post-stroke Spasticity",
        "Spasticity Post-Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "Botulinum toxin type A",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Ipsen",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 352,
      "start_date": "2011-06",
      "completion_date": "2015-04",
      "has_results": true,
      "last_update_posted_date": "2022-09-28",
      "last_synced_at": "2026-07-22T21:46:58.721Z",
      "location_count": 15,
      "location_summary": "Scottsdale, Arizona • Downey, California • Oxnard, California + 12 more",
      "locations": [
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Downey",
          "state": "California"
        },
        {
          "city": "Oxnard",
          "state": "California"
        },
        {
          "city": "Fairfield",
          "state": "Connecticut"
        },
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01251367"
    },
    {
      "nct_id": "NCT04099667",
      "title": "Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Lower Limb Spasticity",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Spasticity"
      ],
      "interventions": [
        {
          "name": "Phase 2; Low Dose MYOBLOC (15,000 Units)",
          "type": "DRUG"
        },
        {
          "name": "Phase 2; High Dose MYOBLOC (20,000 Units)",
          "type": "DRUG"
        },
        {
          "name": "Phase 2; Placebo",
          "type": "DRUG"
        },
        {
          "name": "Phase 3; MYOBLOC",
          "type": "DRUG"
        },
        {
          "name": "Phase 3; Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 40,
      "start_date": "2019-12-17",
      "completion_date": "2023-03-24",
      "has_results": true,
      "last_update_posted_date": "2026-05-22",
      "last_synced_at": "2026-07-22T21:46:58.721Z",
      "location_count": 4,
      "location_summary": "Downey, California • Boise, Idaho • Port Royal, South Carolina + 1 more",
      "locations": [
        {
          "city": "Downey",
          "state": "California"
        },
        {
          "city": "Boise",
          "state": "Idaho"
        },
        {
          "city": "Port Royal",
          "state": "South Carolina"
        },
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04099667"
    },
    {
      "nct_id": "NCT06059872",
      "title": "Biomarkers of Reaction To HIIT Exercise",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Stroke",
        "Stroke Rehabilitation",
        "Lower Extremity Weakness, Spastic",
        "Walking, Difficulty"
      ],
      "interventions": [
        {
          "name": "High Intensity Interval Training (HIIT)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 55,
      "start_date": "2024-01-01",
      "completion_date": "2027-12-01",
      "has_results": false,
      "last_update_posted_date": "2026-03-27",
      "last_synced_at": "2026-07-22T21:46:58.721Z",
      "location_count": 1,
      "location_summary": "Decatur, Georgia",
      "locations": [
        {
          "city": "Decatur",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06059872"
    },
    {
      "nct_id": "NCT05457205",
      "title": "Transcutaneous Spinal Stimulation for Lower Limb Spasticity in Spinal Cord Injury",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spinal Cord Injuries",
        "Spasticity, Muscle"
      ],
      "interventions": [
        {
          "name": "Electrical neuromodulation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Mississippi Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 12,
      "start_date": "2022-08-16",
      "completion_date": "2025-04-05",
      "has_results": false,
      "last_update_posted_date": "2024-04-12",
      "last_synced_at": "2026-07-22T21:46:58.721Z",
      "location_count": 2,
      "location_summary": "Jackson, Mississippi",
      "locations": [
        {
          "city": "Jackson",
          "state": "Mississippi"
        },
        {
          "city": "Jackson",
          "state": "Mississippi"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05457205"
    },
    {
      "nct_id": "NCT01249404",
      "title": "Dysport® Adult Lower Limb Spasticity Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Leg Spasticity"
      ],
      "interventions": [
        {
          "name": "Botulinum toxin type A",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "DRUG"
      ],
      "sponsor": "Ipsen",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 388,
      "start_date": "2011-03",
      "completion_date": "2014-05",
      "has_results": true,
      "last_update_posted_date": "2022-09-28",
      "last_synced_at": "2026-07-22T21:46:58.721Z",
      "location_count": 17,
      "location_summary": "Scottsdale, Arizona • Downey, California • Oxnard, California + 12 more",
      "locations": [
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Downey",
          "state": "California"
        },
        {
          "city": "Oxnard",
          "state": "California"
        },
        {
          "city": "Fairfield",
          "state": "Connecticut"
        },
        {
          "city": "Boca Raton",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01249404"
    },
    {
      "nct_id": "NCT01603628",
      "title": "BOTOX® Treatment in Pediatric Lower Limb Spasticity",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Pediatrics",
        "Muscle Spasticity",
        "Cerebral Palsy"
      ],
      "interventions": [
        {
          "name": "botulinum toxin Type A",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Normal Saline (Placebo)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "DRUG"
      ],
      "sponsor": "Allergan",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Years",
        "maximum_age": "16 Years",
        "sex": "ALL",
        "summary": "2 Years to 16 Years"
      },
      "enrollment_count": 384,
      "start_date": "2012-09-11",
      "completion_date": "2017-06-28",
      "has_results": true,
      "last_update_posted_date": "2018-08-14",
      "last_synced_at": "2026-07-22T21:46:58.721Z",
      "location_count": 24,
      "location_summary": "Pasadena, California • Pomona, California • Aurora, Colorado + 19 more",
      "locations": [
        {
          "city": "Pasadena",
          "state": "California"
        },
        {
          "city": "Pomona",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Fairfield",
          "state": "Connecticut"
        },
        {
          "city": "Stamford",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01603628"
    },
    {
      "nct_id": "NCT01603459",
      "title": "Efficacy and Safety Dose Titration Study of Botulinum Toxin Type A to Treat Spasticity in the Leg and Arm",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Spasticity of the Upper and Lower Limb Due to Cerebral Causes"
      ],
      "interventions": [
        {
          "name": "IncobotulinumtoxinA",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Merz Pharmaceuticals GmbH",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 155,
      "start_date": "2012-05",
      "completion_date": "2014-09",
      "has_results": true,
      "last_update_posted_date": "2017-04-26",
      "last_synced_at": "2026-07-22T21:46:58.721Z",
      "location_count": 6,
      "location_summary": "Doral, Florida • Indianapolis, Indiana • New York, New York + 3 more",
      "locations": [
        {
          "city": "Doral",
          "state": "Florida"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Charlotte",
          "state": "North Carolina"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01603459"
    }
  ]
}