{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=MAJOR+DEPRESSIVE+DISORDER&page=30",
    "query": {
      "condition": "MAJOR DEPRESSIVE DISORDER",
      "page": 30
    },
    "page_size": 10
  },
  "pagination": {
    "page": 30,
    "page_size": 10,
    "total_count": 1788,
    "total_pages": 179,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=MAJOR+DEPRESSIVE+DISORDER&page=31&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=MAJOR+DEPRESSIVE+DISORDER&page=29&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-16T06:06:08.219Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03170362",
      "title": "PRIME Care (PRecision Medicine In MEntal Health Care)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Major Depression"
      ],
      "interventions": [
        {
          "name": "Pharmacogenetic Test",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 1944,
      "start_date": "2017-06-15",
      "completion_date": "2022-03-31",
      "has_results": true,
      "last_update_posted_date": "2024-05-28",
      "last_synced_at": "2026-10-16T06:06:08.219Z",
      "location_count": 24,
      "location_summary": "North Little Rock, Arkansas • Palo Alto, California • San Francisco, California + 21 more",
      "locations": [
        {
          "city": "North Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "West Los Angeles",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03170362"
    },
    {
      "nct_id": "NCT03505905",
      "title": "A Neurosteroid Intervention for Menopausal and Perimenopausal Depression",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Major Depressive Disorder",
        "Menopause",
        "Perimenopause"
      ],
      "interventions": [
        {
          "name": "Pregnenolone",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Texas Southwestern Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "67 Years",
        "sex": "FEMALE",
        "summary": "40 Years to 67 Years · Female only"
      },
      "enrollment_count": 73,
      "start_date": "2018-09-01",
      "completion_date": "2024-12-03",
      "has_results": true,
      "last_update_posted_date": "2026-01-22",
      "last_synced_at": "2026-10-16T06:06:08.219Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03505905"
    },
    {
      "nct_id": "NCT04455646",
      "title": "Combining H1-Coil Deep Transcranial Magnetic Stimulation (dTMS) and App-guided CBT in Subjects With Major Depression Disorder (MDD)",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Data Collection for Facilitation of Machine Learning Algorithm for Personalized Treatment"
      ],
      "interventions": [
        {
          "name": "CBT-based, mobile-delivered, intervention platform",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Brainsway",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "68 Years",
        "sex": "ALL",
        "summary": "22 Years to 68 Years"
      },
      "enrollment_count": 540,
      "start_date": "2019-08-26",
      "completion_date": "2021-08-26",
      "has_results": false,
      "last_update_posted_date": "2020-07-09",
      "last_synced_at": "2026-10-16T06:06:08.219Z",
      "location_count": 22,
      "location_summary": "San Diego, California • Juno Beach, Florida • Palm Beach, Florida + 18 more",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Juno Beach",
          "state": "Florida"
        },
        {
          "city": "Palm Beach",
          "state": "Florida"
        },
        {
          "city": "Royal Palm Beach",
          "state": "Florida"
        },
        {
          "city": "Annapolis",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04455646"
    },
    {
      "nct_id": "NCT00517036",
      "title": "Omega-3 Fatty Acids for Treating Adults With Major Depression",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Depression"
      ],
      "interventions": [
        {
          "name": "EPA omega-3 fatty acid",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "DHA omega-3 fatty acid",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo comparator",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Cedars-Sinai Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 196,
      "start_date": "2006-07",
      "completion_date": "2011-01",
      "has_results": false,
      "last_update_posted_date": "2013-04-04",
      "last_synced_at": "2026-10-16T06:06:08.219Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00517036"
    },
    {
      "nct_id": "NCT07684521",
      "title": "Debriefing Consult for Psychiatric Symptoms After Severe Maternal Morbidity",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "PTSD (Childbirth-Related)",
        "Severe Maternal Morbidity",
        "Depression - Major Depressive Disorder",
        "Anxiety"
      ],
      "interventions": [
        {
          "name": "Virtual maternal fetal medicine debriefing consult",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Cedars-Sinai Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 52,
      "start_date": "2026-07-01",
      "completion_date": "2030-07",
      "has_results": false,
      "last_update_posted_date": "2026-07-06",
      "last_synced_at": "2026-10-16T06:06:08.219Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07684521"
    },
    {
      "nct_id": "NCT01685294",
      "title": "Effectiveness of Interpersonal Psychotherapy (IPT) for Men and Women Prisoners With Major Depression",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Major Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "Group IPT for Depression + TAU",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Brown University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 181,
      "start_date": "2011-12",
      "completion_date": "2014-10",
      "has_results": false,
      "last_update_posted_date": "2016-01-13",
      "last_synced_at": "2026-10-16T06:06:08.219Z",
      "location_count": 5,
      "location_summary": "Bridgewater, Massachusetts • Framingham, Massachusetts • Norfolk, Massachusetts + 1 more",
      "locations": [
        {
          "city": "Bridgewater",
          "state": "Massachusetts"
        },
        {
          "city": "Framingham",
          "state": "Massachusetts"
        },
        {
          "city": "Framingham",
          "state": "Massachusetts"
        },
        {
          "city": "Norfolk",
          "state": "Massachusetts"
        },
        {
          "city": "Cranston",
          "state": "Rhode Island"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01685294"
    },
    {
      "nct_id": "NCT02579928",
      "title": "Ketamine Infusion for Adolescent Depression and Anxiety",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Major Depressive Disorder",
        "Anxiety Disorder"
      ],
      "interventions": [
        {
          "name": "Ketamine",
          "type": "DRUG"
        },
        {
          "name": "Midazolam",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "13 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "13 Years to 17 Years"
      },
      "enrollment_count": 17,
      "start_date": "2015-10",
      "completion_date": "2019-09",
      "has_results": true,
      "last_update_posted_date": "2020-07-14",
      "last_synced_at": "2026-10-16T06:06:08.219Z",
      "location_count": 2,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02579928"
    },
    {
      "nct_id": "NCT00086307",
      "title": "Lexapro and Pramipexole and to Treat Major Depression",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Major Depression"
      ],
      "interventions": [
        {
          "name": "Pramipexole",
          "type": "DRUG"
        },
        {
          "name": "Escitalopram",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Institute of Mental Health (NIMH)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 39,
      "start_date": "2004-06",
      "completion_date": "2010-03",
      "has_results": true,
      "last_update_posted_date": "2013-01-28",
      "last_synced_at": "2026-10-16T06:06:08.219Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00086307"
    },
    {
      "nct_id": "NCT05966532",
      "title": "Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults With Depression",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Major Depressive Disorder (MDD)",
        "Healthy Adult Volunteer"
      ],
      "interventions": [
        {
          "name": "Hot Cognitive Task",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Cold cognitive tasks",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Structural magnetic resonance imaging (sMRI)",
          "type": "OTHER"
        },
        {
          "name": "Magnetoencephalography imaging (MEG)",
          "type": "OTHER"
        },
        {
          "name": "four self-report forms per the requirement of the NIH Common Data Elements project",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Four self-report measures to assess interpersonal functioning",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Clinical assessments",
          "type": "BEHAVIORAL"
        },
        {
          "name": "ATHF",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "University of Texas Southwestern Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "21 Years to 80 Years"
      },
      "enrollment_count": 276,
      "start_date": "2023-12-11",
      "completion_date": "2027-08-31",
      "has_results": false,
      "last_update_posted_date": "2026-07-30",
      "last_synced_at": "2026-10-16T06:06:08.219Z",
      "location_count": 2,
      "location_summary": "Arlington, Texas • Dallas, Texas",
      "locations": [
        {
          "city": "Arlington",
          "state": "Texas"
        },
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05966532"
    },
    {
      "nct_id": "NCT03857581",
      "title": "Clozapine Versus Olanzapine as Treatment for Comorbid Psychotic Disorder and Substance Use Disorder",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Psychosis",
        "Substance Use Disorders"
      ],
      "interventions": [
        {
          "name": "Clozapine",
          "type": "DRUG"
        },
        {
          "name": "Olanzapine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Augusta University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 100,
      "start_date": "2020-07",
      "completion_date": "2021-07",
      "has_results": false,
      "last_update_posted_date": "2020-03-23",
      "last_synced_at": "2026-10-16T06:06:08.219Z",
      "location_count": 1,
      "location_summary": "Evans, Georgia",
      "locations": [
        {
          "city": "Evans",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03857581"
    }
  ]
}