{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=MSH2+Loss+of+Expression",
    "query": {
      "condition": "MSH2 Loss of Expression"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 3,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-25T16:17:53.848Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06708429",
      "title": "Lynch Syndrome X-Talk of Enteral Mucosa With Immune System",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Lynch Syndrome",
        "Lynch Syndrome I",
        "Lynch Syndrome II",
        "Lynch Syndrome I (Site-specific Colonic Cancer)",
        "HNPCC",
        "HNPCC Gene Mutation",
        "Hereditary Cancer Syndrome",
        "Hereditary Cancer",
        "MLH1 Gene Mutation",
        "MLH1 Gene Deletion+Duplication",
        "MLH1 Loss of Expression",
        "MLH1 Gene Inactivation",
        "MSH2 Gene Mutation",
        "MSH2 Gene Deletion+Duplication",
        "MSH2 Loss of Expression",
        "MSH2 Gene Inactivation",
        "MSH6 Gene Mutation",
        "MSH6 Loss of Expression",
        "MSH6 Gene Inactivation",
        "PMS2 Gene Mutation",
        "PMS2 Gene Inactivation",
        "PMS2 Loss of Expression"
      ],
      "interventions": [
        {
          "name": "LYNX EYE (Lynch syndrome X-Talk of Enteral mucosa with Immune System)",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "San Raffaele University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 300,
      "start_date": "2023-06-01",
      "completion_date": "2034-06-01",
      "has_results": false,
      "last_update_posted_date": "2026-04-24",
      "last_synced_at": "2026-06-25T16:17:53.848Z",
      "location_count": 1,
      "location_summary": "Monrovia, California",
      "locations": [
        {
          "city": "Monrovia",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06708429"
    },
    {
      "nct_id": "NCT01876511",
      "title": "Study of MK-3475 in Patients With Microsatellite Unstable (MSI) Tumors (Cohorts A, B and C)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "MSI Positive Colorectal Cancer",
        "MSI Negative Colorectal Cancer",
        "MSI Positive Non-Colorectal Cancers"
      ],
      "interventions": [
        {
          "name": "MK-3475",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 113,
      "start_date": "2013-09",
      "completion_date": "2019-08",
      "has_results": true,
      "last_update_posted_date": "2020-02-06",
      "last_synced_at": "2026-06-25T16:17:53.848Z",
      "location_count": 7,
      "location_summary": "Stanford, California • Baltimore, Maryland • Bethesda, Maryland + 4 more",
      "locations": [
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Bethesda",
          "state": "Maryland"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01876511"
    },
    {
      "nct_id": "NCT02993068",
      "title": "Stand up to Cancer: MAGENTA (Making Genetic Testing Accessible)",
      "overall_status": "SUSPENDED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "BARD1 Gene Mutation",
        "BRCA1 Gene Mutation",
        "BRCA2 Gene Mutation",
        "BRIP1 Gene Mutation",
        "Estrogen Receptor Negative",
        "HER2/Neu Negative",
        "MLH1 Gene Mutation",
        "MSH2 Gene Mutation",
        "MSH6 Gene Mutation",
        "PALB2 Gene Mutation",
        "PMS2 Gene Mutation",
        "Progesterone Receptor Negative",
        "RAD51C Gene Mutation",
        "RAD51D Gene Mutation",
        "Triple-Negative Breast Carcinoma"
      ],
      "interventions": [
        {
          "name": "Educational Intervention",
          "type": "OTHER"
        },
        {
          "name": "Genetic Counseling",
          "type": "OTHER"
        },
        {
          "name": "Laboratory Biomarker Analysis",
          "type": "OTHER"
        },
        {
          "name": "Questionnaire Administration",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "M.D. Anderson Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "30 Years and older · Female only"
      },
      "enrollment_count": 5200,
      "start_date": "2017-04-18",
      "completion_date": "2026-04-18",
      "has_results": false,
      "last_update_posted_date": "2026-02-19",
      "last_synced_at": "2026-06-25T16:17:53.848Z",
      "location_count": 2,
      "location_summary": "Houston, Texas • Seattle, Washington",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        },
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02993068"
    }
  ]
}