{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Major+Depressive+Disorder%2C+Recurrent",
    "query": {
      "condition": "Major Depressive Disorder, Recurrent"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 37,
    "total_pages": 4,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Major+Depressive+Disorder%2C+Recurrent&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T04:51:41.684Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01145872",
      "title": "The Effects and Mechanisms of Mindfulness Based Cognitive Therapy (MBCT) on Depressive Symptoms and Depression Relapse",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Major Depressive Disorder",
        "Recurrent"
      ],
      "interventions": [
        {
          "name": "Mindfulness Based Cognitive Therapy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Health Enhancement Program",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 92,
      "start_date": "2010-07",
      "completion_date": "2013-04",
      "has_results": false,
      "last_update_posted_date": "2014-12-02",
      "last_synced_at": "2026-05-22T04:51:41.684Z",
      "location_count": 1,
      "location_summary": "Denver, Colorado",
      "locations": [
        {
          "city": "Denver",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01145872"
    },
    {
      "nct_id": "NCT04481737",
      "title": "Peer-delivered and Technology-Assisted Integrated Illness Management and Recovery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Schizophrenia",
        "Bipolar Disorder",
        "Major Depressive Disorder, Recurrent",
        "Obesity",
        "Cardiovascular Diseases",
        "Diabetes",
        "Smoking",
        "Blood Pressure Disorders",
        "Cholesterol, Elevated"
      ],
      "interventions": [
        {
          "name": "Peer-delivered and Technology Support Integrated Illness Management and Recovery",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Peer support",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Dartmouth-Hitchcock Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 40,
      "start_date": "2021-02-01",
      "completion_date": "2024-01-01",
      "has_results": false,
      "last_update_posted_date": "2024-01-24",
      "last_synced_at": "2026-05-22T04:51:41.684Z",
      "location_count": 1,
      "location_summary": "Cambridge, Massachusetts",
      "locations": [
        {
          "city": "Cambridge",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04481737"
    },
    {
      "nct_id": "NCT06113575",
      "title": "Practical Application of Accelerated iTBS for MDD",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Major Depressive Disorder",
        "Major Depressive Disorder, Recurrent Episode, Severe",
        "Major Depressive Disorder, Recurrent, Moderate"
      ],
      "interventions": [
        {
          "name": "NeuroStar TMS",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Sonder Behavioral Health and Wellness",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "22 Years to 70 Years"
      },
      "enrollment_count": 21,
      "start_date": "2022-11-23",
      "completion_date": "2023-07-28",
      "has_results": false,
      "last_update_posted_date": "2023-11-07",
      "last_synced_at": "2026-05-22T04:51:41.684Z",
      "location_count": 1,
      "location_summary": "Minnetonka, Minnesota",
      "locations": [
        {
          "city": "Minnetonka",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06113575"
    },
    {
      "nct_id": "NCT00585585",
      "title": "Pilot Study of Betahistine Dihydrochloride in the Treatment of Major Depression With Atypical Features",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Recurrent Major Depressive Disorder With Atypical Features"
      ],
      "interventions": [
        {
          "name": "betahistine dihydrochloride",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Cincinnati",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 1,
      "start_date": "2007-07",
      "completion_date": "2011-01",
      "has_results": true,
      "last_update_posted_date": "2017-07-25",
      "last_synced_at": "2026-05-22T04:51:41.684Z",
      "location_count": 1,
      "location_summary": "Cincinnati, Ohio",
      "locations": [
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00585585"
    },
    {
      "nct_id": "NCT04740879",
      "title": "The Effects of the Be Mindful Intervention in Previously Depressed Individuals Experiencing Subclinical Symptoms",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Depressive Symptoms",
        "Major Depressive Disorder, Recurrent, in Remission"
      ],
      "interventions": [
        {
          "name": "Be Mindful",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "State University of New York at Buffalo",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 137,
      "start_date": "2021-03-30",
      "completion_date": "2022-08-01",
      "has_results": false,
      "last_update_posted_date": "2023-05-18",
      "last_synced_at": "2026-05-22T04:51:41.684Z",
      "location_count": 1,
      "location_summary": "Buffalo, New York",
      "locations": [
        {
          "city": "Buffalo",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04740879"
    },
    {
      "nct_id": "NCT00208156",
      "title": "A United States Extension Study of Corlux for Recurrent Psychotic Symptoms in Psychotic Major Depression",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Depressive Disorder, Major"
      ],
      "interventions": [
        {
          "name": "Mifepristone",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Corcept Therapeutics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 87,
      "start_date": "2005-05",
      "completion_date": "2006-11",
      "has_results": false,
      "last_update_posted_date": "2012-02-15",
      "last_synced_at": "2026-05-22T04:51:41.684Z",
      "location_count": 13,
      "location_summary": "San Diego, California • Atlanta, Georgia • Las Vegas, Nevada + 10 more",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Las Vegas",
          "state": "Nevada"
        },
        {
          "city": "Clementon",
          "state": "New Jersey"
        },
        {
          "city": "Newark",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00208156"
    },
    {
      "nct_id": "NCT03254342",
      "title": "MRS and Medication Response: A Pilot Study",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Major Depressive Disorder",
        "Major Depressive Episode",
        "Major Depressive Disorder, Recurrent",
        "Major Depression Mild",
        "Major Depression Moderate",
        "Major Depression Severe"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "21 Years to 75 Years"
      },
      "enrollment_count": 3,
      "start_date": "2013-08-06",
      "completion_date": "2020-08-31",
      "has_results": false,
      "last_update_posted_date": "2021-08-19",
      "last_synced_at": "2026-05-22T04:51:41.684Z",
      "location_count": 1,
      "location_summary": "Stanford, California",
      "locations": [
        {
          "city": "Stanford",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03254342"
    },
    {
      "nct_id": "NCT01714050",
      "title": "Cognitive-behavioral Therapy vs. Light Therapy for Preventing SAD Recurrence",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Seasonal Affective Disorder (SAD)",
        "Winter Depression",
        "Major Depressive Disorder, Recurrent, With Seasonal Pattern"
      ],
      "interventions": [
        {
          "name": "Cognitive-Behavioral Therapy (CBT)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Light Therapy (LT)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DEVICE"
      ],
      "sponsor": "University of Vermont",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 177,
      "start_date": "2008-07",
      "completion_date": "2014-02",
      "has_results": false,
      "last_update_posted_date": "2023-05-09",
      "last_synced_at": "2026-05-22T04:51:41.684Z",
      "location_count": 1,
      "location_summary": "Burlington, Vermont",
      "locations": [
        {
          "city": "Burlington",
          "state": "Vermont"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01714050"
    },
    {
      "nct_id": "NCT03859297",
      "title": "Mechanisms of Rumination Change in Adolescent Depression",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Major Depressive Disorder",
        "Mood Disorders"
      ],
      "interventions": [
        {
          "name": "Rumination-Focused CBT",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Relaxation-based Therapy",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Ohio State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "14 Years to 17 Years"
      },
      "enrollment_count": 183,
      "start_date": "2019-05-01",
      "completion_date": "2029-03-02",
      "has_results": false,
      "last_update_posted_date": "2025-08-11",
      "last_synced_at": "2026-05-22T04:51:41.684Z",
      "location_count": 3,
      "location_summary": "Columbus, Ohio • Salt Lake City, Utah",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03859297"
    },
    {
      "nct_id": "NCT00985725",
      "title": "SPD489 in Adults With Persistent Executive Function Impairments (EFI) and Partial or Full Remission of Recurrent Major Depressive Disorder",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Major Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "SPD489 (Lisdexamfetamine dimesylate)",
          "type": "DRUG"
        },
        {
          "name": "Matching placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Shire",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 143,
      "start_date": "2009-10-29",
      "completion_date": "2011-04-18",
      "has_results": true,
      "last_update_posted_date": "2021-06-08",
      "last_synced_at": "2026-05-22T04:51:41.684Z",
      "location_count": 33,
      "location_summary": "Imperial, California • Los Alamitos, California • Oceanside, California + 28 more",
      "locations": [
        {
          "city": "Imperial",
          "state": "California"
        },
        {
          "city": "Los Alamitos",
          "state": "California"
        },
        {
          "city": "Oceanside",
          "state": "California"
        },
        {
          "city": "Santa Ana",
          "state": "California"
        },
        {
          "city": "Cromwell",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00985725"
    }
  ]
}