{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Major+Depressive+Disorders&page=25",
    "query": {
      "condition": "Major Depressive Disorders",
      "page": 25
    },
    "page_size": 10
  },
  "pagination": {
    "page": 25,
    "page_size": 10,
    "total_count": 1755,
    "total_pages": 176,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Major+Depressive+Disorders&page=26&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Major+Depressive+Disorders&page=24&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-30T03:02:10.185Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT07594483",
      "title": "Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Major Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "Motif XCS System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Motif Neurotech, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "22 Years to 85 Years"
      },
      "enrollment_count": 20,
      "start_date": "2026-09",
      "completion_date": "2027-12",
      "has_results": false,
      "last_update_posted_date": "2026-10-21",
      "last_synced_at": "2026-10-30T03:02:10.185Z",
      "location_count": 3,
      "location_summary": "Atlanta, Georgia • Iowa City, Iowa • Houston, Texas",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Iowa City",
          "state": "Iowa"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07594483"
    },
    {
      "nct_id": "NCT00380042",
      "title": "Assessment of the Safety and Effectiveness of Cortical Stimulation in Subjects With Major Depressive Disorder",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Depression",
        "Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "Cortical Stimulation",
          "type": "DEVICE"
        },
        {
          "name": "Sham",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Northstar Neuroscience",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 12,
      "start_date": "2006-09",
      "completion_date": "2009-03",
      "has_results": false,
      "last_update_posted_date": "2009-12-31",
      "last_synced_at": "2026-10-30T03:02:10.185Z",
      "location_count": 3,
      "location_summary": "Boston, Massachusetts • Pittsburgh, Pennsylvania • Milwaukee, Wisconsin",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        },
        {
          "city": "Milwaukee",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00380042"
    },
    {
      "nct_id": "NCT04031469",
      "title": "A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease",
      "overall_status": "SUSPENDED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Gut Microbiome",
        "Gastrointestinal Microbiome",
        "Autism",
        "Autism Spectrum Disorder",
        "Autism Spectrum Disorder High-Functioning",
        "Alzheimer Disease",
        "Alzheimer Dementia (AD)",
        "Alzheimer Dementia",
        "Alzheimer Disease (AD)",
        "Crohn",
        "Crohn Colitis",
        "Crohn Disease (CD)",
        "Crohn Disease Colon",
        "Myalgic Encephalomyelitis",
        "ME/CFS",
        "Myalgic Encephalomyelitis (ME)",
        "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome",
        "Psoriasis",
        "Psoriasis Annularis",
        "Psoriasis Chronic",
        "Chronic Urinary Tract Infection",
        "Ulcerative Colitis (Disorder)",
        "Ulcerative Colitis (UC)",
        "Ulcerative Colitis Acute",
        "Ulcerative Colitis Chronic",
        "Multiple Sclerosis",
        "Multiple Sclerosis (MS) - Relapsing-remitting",
        "Multiple Sclerosis (MS) Primary Progressive",
        "Constipation Chronic Idiopathic",
        "Constipation",
        "Celiac",
        "Celiac Disease",
        "Celiac Sprue",
        "Lyme Arthritis",
        "Lyme Borreliosis, Nervous System",
        "Lyme Disease, Chronic",
        "Cholesterol",
        "Cholesterol Level, High",
        "Cancer",
        "Colon Cancer",
        "Amyotrophic Lateral Sclerosis (ALS)",
        "Amyotrophic Lateral Sclerosis",
        "Rheumatoid Arthritis (RA)",
        "Rheumatoid Arthritis - Rheumatism",
        "Chronic Fatigue Syndrome (CFS)",
        "PARKINSON DISEASE (Disorder)",
        "Parkinson Disease",
        "Parkinson Disease (PD)",
        "Depression",
        "Major Depressive Disorder (MDD)",
        "Depression Disorder",
        "Depression in Adults",
        "Anxiety",
        "Anxiety Disorder Generalized",
        "Obsessive Compulsive Disorder (OCD)",
        "Obsessive Compulsive Disorder OCD",
        "Obsessive - Compulsive Disorder",
        "Bipolar",
        "Bipolar 1 Disorder",
        "Bipolar Disorder (BD)",
        "Bipolar Disorder I and II",
        "Bipolar and Related Disorders",
        "Migraine",
        "Migraine Disorder",
        "Diabetes (DM)",
        "Diabetes",
        "Lupus",
        "Lupus Erythematosus",
        "Epidermolysis Bullosa (EB)",
        "Mesothelioma",
        "Mesothelioma Malignant",
        "IBS (Irritable Bowel Syndrome)",
        "Irritable Bowel",
        "IBS - Irritable Bowel Syndrome",
        "Irritable Bowel Syndrome (IBS)",
        "Eczema",
        "Eczema Atopic Dermatitis",
        "Acne",
        "Myasthaenia Gravis",
        "Gout"
      ],
      "interventions": [
        {
          "name": "There is no intervention in this study",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "ProgenaBiome",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "12 Years and older"
      },
      "enrollment_count": 1000,
      "start_date": "2019-07-11",
      "completion_date": "2030-12-10",
      "has_results": false,
      "last_update_posted_date": "2026-09-21",
      "last_synced_at": "2026-10-30T03:02:10.185Z",
      "location_count": 1,
      "location_summary": "Ventura, California",
      "locations": [
        {
          "city": "Ventura",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04031469"
    },
    {
      "nct_id": "NCT04106466",
      "title": "DBS for TRD With the Medtronic Summit RC+S",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Major Depressive Disorder",
        "Treatment Resistant Depression"
      ],
      "interventions": [
        {
          "name": "Medtronic Summit RC+S DBS system",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Helen Mayberg, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "25 Years to 70 Years"
      },
      "enrollment_count": 10,
      "start_date": "2020-01-21",
      "completion_date": "2030-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-06-22",
      "last_synced_at": "2026-10-30T03:02:10.185Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04106466"
    },
    {
      "nct_id": "NCT05977439",
      "title": "RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Depression",
        "Major Depressive Disorder",
        "Suicidal Ideation"
      ],
      "interventions": [
        {
          "name": "Single-Pulse Transcranial Magnetic Stimulation",
          "type": "DEVICE"
        },
        {
          "name": "EEG-Synchronized Repetitive Transcranial Magnetic Stimulation (rTMS)",
          "type": "DEVICE"
        },
        {
          "name": "Cognitive Behavioral Therapy (CBT)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Cognitive Flexibility and Emotion Regulation Tasks",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "BEHAVIORAL"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 120,
      "start_date": "2024-02-01",
      "completion_date": "2028-10-01",
      "has_results": false,
      "last_update_posted_date": "2026-07-21",
      "last_synced_at": "2026-10-30T03:02:10.185Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05977439"
    },
    {
      "nct_id": "NCT02476877",
      "title": "A Pilot, Proof-of-concept Cohort Study of the Prevalence of Comorbid Mental Illness and Substance Abuse",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Schizophrenia",
        "Drug Abuse",
        "Anxiety Disorder",
        "Bipolar Disorder",
        "Major Depression"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Advanced Clinical Laboratory Solutions, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 75,
      "start_date": "2014-06",
      "completion_date": "2016-02",
      "has_results": false,
      "last_update_posted_date": "2017-01-24",
      "last_synced_at": "2026-10-30T03:02:10.185Z",
      "location_count": 1,
      "location_summary": "Brooklyn, New York",
      "locations": [
        {
          "city": "Brooklyn",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02476877"
    },
    {
      "nct_id": "NCT01185977",
      "title": "Biomarkers of Antidepressant Treatment in Adolescents With Major Depression (The Adolescents MDD Study)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Major Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "Fluoxetine",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of California, Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "14 Years to 18 Years"
      },
      "enrollment_count": 26,
      "start_date": "2010-04",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2014-07-03",
      "last_synced_at": "2026-10-30T03:02:10.185Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01185977"
    },
    {
      "nct_id": "NCT07373470",
      "title": "An Evaluation of the Impact of Pharmacist Comprehensive Medication Management With Pharmacogenomic Results to Improve Depression Outcomes in Community Pharmacies.",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pharmacogenetics",
        "Depression - Major Depressive Disorder",
        "Pharmacogenomic Drug Interaction",
        "Community Pharmacy Services"
      ],
      "interventions": [
        {
          "name": "Comprehensive medication management with PGx testing results",
          "type": "OTHER"
        },
        {
          "name": "Usual Care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 220,
      "start_date": "2026-09-09",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-09-14",
      "last_synced_at": "2026-10-30T03:02:10.185Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07373470"
    },
    {
      "nct_id": "NCT01710202",
      "title": "Sensitivity of Short and Long Allele Carriers of the 5-HTTLPR to Environmental Threat Post Hydrocortisone Administration",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Major Depressive Disorder",
        "Anxiety Disorders"
      ],
      "interventions": [
        {
          "name": "Hydrocortisone",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Texas at Austin",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 120,
      "start_date": "2012-10",
      "completion_date": "2014-11",
      "has_results": false,
      "last_update_posted_date": "2015-03-20",
      "last_synced_at": "2026-10-30T03:02:10.185Z",
      "location_count": 2,
      "location_summary": "Austin, Texas",
      "locations": [
        {
          "city": "Austin",
          "state": "Texas"
        },
        {
          "city": "Austin",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01710202"
    },
    {
      "nct_id": "NCT03378570",
      "title": "rTMS for MDD: 5.5cm Rule vs. F3 Targeting",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Major Depressive Disorder",
        "Depression"
      ],
      "interventions": [
        {
          "name": "Repetitive transcranial magnetic stimulation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Nicholas Trapp",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 123,
      "start_date": "2018-05-01",
      "completion_date": "2022-09-13",
      "has_results": true,
      "last_update_posted_date": "2025-02-03",
      "last_synced_at": "2026-10-30T03:02:10.185Z",
      "location_count": 1,
      "location_summary": "Iowa City, Iowa",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03378570"
    }
  ]
}