{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Major+Injury",
    "query": {
      "condition": "Major Injury"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 422,
    "total_pages": 43,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Major+Injury&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-26T06:08:48.341Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03307070",
      "title": "Adapted Cognitive Behavioral Treatment for Depression in Patients With Moderate to Severe Traumatic Brain Injury",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Major Depressive Disorder",
        "Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "Cognitive Behavioral Therapy for individuals with TBI",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Waitlist Control",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 62,
      "start_date": "2017-09-23",
      "completion_date": "2022-11-28",
      "has_results": false,
      "last_update_posted_date": "2023-04-10",
      "last_synced_at": "2026-06-26T06:08:48.341Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03307070"
    },
    {
      "nct_id": "NCT01803802",
      "title": "Effects of Early Abuse on Adult Intimate Relationships",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypoactive Sexual Desire Disorder",
        "Female Sexual Arousal Disorder",
        "Female Orgasmic Disorder",
        "Major Depressive Disorder",
        "Post-traumatic Stress Disorder"
      ],
      "interventions": [
        {
          "name": "Expressive writing",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Texas at Austin",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 148,
      "start_date": "2005-04",
      "completion_date": "2014-08",
      "has_results": false,
      "last_update_posted_date": "2014-12-02",
      "last_synced_at": "2026-06-26T06:08:48.341Z",
      "location_count": 1,
      "location_summary": "Austin, Texas",
      "locations": [
        {
          "city": "Austin",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01803802"
    },
    {
      "nct_id": "NCT05837845",
      "title": "MDMA-assisted Cognitive Processing Therapy Versus Cognitive Processing Therapy for Veterans With Severe Posttraumatic Stress Disorder",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "PTSD"
      ],
      "interventions": [
        {
          "name": "MDMA",
          "type": "DRUG"
        },
        {
          "name": "Cognitive Processing Therapy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "MDMA-assisted Cognitive Processing Therapy (MDMA-aCPT)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "Patricia Suppes",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2025-02-10",
      "completion_date": "2027-12",
      "has_results": false,
      "last_update_posted_date": "2025-07-31",
      "last_synced_at": "2026-06-26T06:08:48.341Z",
      "location_count": 1,
      "location_summary": "Palo Alto, California",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05837845"
    },
    {
      "nct_id": "NCT04465929",
      "title": "Expanded Access - Autologous Human Schwann Cells in Peripheral Nerve Repair",
      "overall_status": "NO_LONGER_AVAILABLE",
      "study_type": "EXPANDED_ACCESS",
      "phases": [],
      "conditions": [
        "Peripheral Nerve Injuries"
      ],
      "interventions": [
        {
          "name": "Autologous Human Schwann Cells",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "W. Dalton Dietrich",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": "16 Years",
        "sex": "FEMALE",
        "summary": "16 Years to 16 Years · Female only"
      },
      "enrollment_count": null,
      "start_date": null,
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2020-07-10",
      "last_synced_at": "2026-06-26T06:08:48.341Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04465929"
    },
    {
      "nct_id": "NCT06062628",
      "title": "Ketamine in Severe Traumatic Brain Injury",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Traumatic Brain Injury",
        "Traumatic Encephalopathy"
      ],
      "interventions": [
        {
          "name": "Ketamine Hydrochloride",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Texas Southwestern Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 10,
      "start_date": "2026-06-01",
      "completion_date": "2027-06",
      "has_results": false,
      "last_update_posted_date": "2026-01-14",
      "last_synced_at": "2026-06-26T06:08:48.341Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06062628"
    },
    {
      "nct_id": "NCT02874131",
      "title": "Behavioral Activation + Cognitive Processing Therapy for PTSD and Comorbid MDD",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Posttraumatic Stress Disorder",
        "Major Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "Behavioral Activation",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Cognitive Processing Therapy",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "United States Naval Medical Center, San Diego",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2015-10-20",
      "completion_date": "2022-03-18",
      "has_results": false,
      "last_update_posted_date": "2024-11-15",
      "last_synced_at": "2026-06-26T06:08:48.341Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02874131"
    },
    {
      "nct_id": "NCT06805851",
      "title": "Impact of Depression on Thermoregulation",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Depression",
        "Selective Serotonin Reuptake Inhibitor"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Penn State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 64,
      "start_date": "2025-03-01",
      "completion_date": "2027-01-30",
      "has_results": false,
      "last_update_posted_date": "2026-02-03",
      "last_synced_at": "2026-06-26T06:08:48.341Z",
      "location_count": 1,
      "location_summary": "University Park, Pennsylvania",
      "locations": [
        {
          "city": "University Park",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06805851"
    },
    {
      "nct_id": "NCT03695939",
      "title": "Evaluation of Safety and Efficacy of realSKIN® (Skin Xenotransplant) for Complete Closure of Severe Burn Wounds",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Deep Full-thickness Burn Injury (Disorder)"
      ],
      "interventions": [
        {
          "name": "realSKIN (skin xenotransplant)",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Human Cadaver Allograft",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "XenoTherapeutics, Inc.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 25,
      "start_date": "2019-03-15",
      "completion_date": "2023-12-30",
      "has_results": false,
      "last_update_posted_date": "2024-01-12",
      "last_synced_at": "2026-06-26T06:08:48.341Z",
      "location_count": 2,
      "location_summary": "Augusta, Georgia • Boston, Massachusetts",
      "locations": [
        {
          "city": "Augusta",
          "state": "Georgia"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03695939"
    },
    {
      "nct_id": "NCT00961454",
      "title": "Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major Depression",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Major Depression",
        "Anxiety Disorder",
        "Post-Traumatic Stress Disorder",
        "Substance Abuse Disorder"
      ],
      "interventions": [
        {
          "name": "Photobiomodulation with a super-luminous light emitting diode",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 10,
      "start_date": "2009-01",
      "completion_date": "2009-06",
      "has_results": false,
      "last_update_posted_date": "2009-08-19",
      "last_synced_at": "2026-06-26T06:08:48.341Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00961454"
    },
    {
      "nct_id": "NCT05366270",
      "title": "Peripheral Neuroimmune Mechanisms of Hyperthermia",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hyperthermia",
        "Major Depressive Disorder",
        "Inflammation"
      ],
      "interventions": [
        {
          "name": "WBH",
          "type": "DEVICE"
        },
        {
          "name": "Sham",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 60,
      "start_date": "2022-11-01",
      "completion_date": "2024-06",
      "has_results": false,
      "last_update_posted_date": "2023-03-10",
      "last_synced_at": "2026-06-26T06:08:48.341Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05366270"
    }
  ]
}