{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Methadone+Toxicity",
    "query": {
      "condition": "Methadone Toxicity"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 3,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-21T23:45:51.285Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06837571",
      "title": "Methadone Dose Monitoring With a Remote Medication Monitor",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Methadone Toxicity",
        "Methadone Overdose",
        "Pain, Chronic",
        "Drug Metabolism, Poor, CYP2D6-Related",
        "Metabolism Medication Toxicity"
      ],
      "interventions": [
        {
          "name": "Measurement of Methadone in the Interstitial Fluid (ISF) before and after prescribed dose taken ex vivo",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Measurement of Methadone in the Interstitial Fluid before and after prescribed dose taken in vivo",
          "type": "DRUG"
        },
        {
          "name": "ISF Extraction Device 2",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST",
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Cari Health Inc.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 30,
      "start_date": "2025-04-26",
      "completion_date": "2025-06",
      "has_results": false,
      "last_update_posted_date": "2025-02-20",
      "last_synced_at": "2026-05-21T23:45:51.285Z",
      "location_count": 1,
      "location_summary": "Lemon Grove, California",
      "locations": [
        {
          "city": "Lemon Grove",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06837571"
    },
    {
      "nct_id": "NCT05981573",
      "title": "Assessment of Methadone Dose Taken",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Methadone Toxicity",
        "Methadone Overdose",
        "Pain, Chronic",
        "Drug Metabolism, Poor, CYP2D6-Related",
        "Metabolism Medication Toxicity"
      ],
      "interventions": [
        {
          "name": "Measurement of Methadone in the Interstitial Fluid (ISF) before and after prescribed dose taken ex vivo",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Measurement of Methadone in the Interstitial Fluid before and after prescribed dose taken in vivo",
          "type": "DRUG"
        },
        {
          "name": "ISF Extraction Device 2",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST",
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Cari Health Inc.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 30,
      "start_date": "2024-08-26",
      "completion_date": "2026-04",
      "has_results": false,
      "last_update_posted_date": "2025-02-13",
      "last_synced_at": "2026-05-21T23:45:51.285Z",
      "location_count": 1,
      "location_summary": "Lemon Grove, California",
      "locations": [
        {
          "city": "Lemon Grove",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05981573"
    },
    {
      "nct_id": "NCT03574792",
      "title": "Gabapentin, Methadone, and Oxycodone With or Without Venlafaxine Hydrochloride in Managing Pain in Participants With Stage II-IV Squamous Cell Head and Neck Cancer Undergoing Chemoradiation Therapy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8",
        "Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8"
      ],
      "interventions": [
        {
          "name": "Gabapentin",
          "type": "DRUG"
        },
        {
          "name": "Methadone",
          "type": "DRUG"
        },
        {
          "name": "Oxycodone",
          "type": "DRUG"
        },
        {
          "name": "Quality-of-Life Assessment",
          "type": "OTHER"
        },
        {
          "name": "Questionnaire Administration",
          "type": "OTHER"
        },
        {
          "name": "Venlafaxine",
          "type": "DRUG"
        },
        {
          "name": "Venlafaxine Hydrochloride Extended Release",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Roswell Park Cancer Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 62,
      "start_date": "2018-05-03",
      "completion_date": "2021-11-11",
      "has_results": true,
      "last_update_posted_date": "2026-04-16",
      "last_synced_at": "2026-05-21T23:45:51.285Z",
      "location_count": 1,
      "location_summary": "Buffalo, New York",
      "locations": [
        {
          "city": "Buffalo",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03574792"
    }
  ]
}