{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Middle-ear+Barotrauma",
    "query": {
      "condition": "Middle-ear Barotrauma"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 6,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T09:04:57.964Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04804098",
      "title": "Effect of Rate (Slope) of Compression on the Incidence of Symptomatic ETD and MEB: a Phase III Prospective Study.",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ear Barotrauma",
        "Middle Ear Disease",
        "Ear Diseases",
        "Pressure Injury",
        "Eustachian Tube Dysfunction",
        "Middle Ear; Injury",
        "Middle Ear Barotrauma"
      ],
      "interventions": [
        {
          "name": "Compression Profile/Schedule: 15 minute Non-Linear compression from start of the daily treatment until treatment pressure is reached (45 fsw)",
          "type": "PROCEDURE"
        },
        {
          "name": "Compression Profile/Schedule: 15 minute Linear compression from start of the daily treatment until treatment pressure is reached (45 fsw)",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Northwell Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 300,
      "start_date": "2021-09-20",
      "completion_date": "2024-12-01",
      "has_results": false,
      "last_update_posted_date": "2023-10-19",
      "last_synced_at": "2026-05-22T09:04:57.964Z",
      "location_count": 1,
      "location_summary": "Sleepy Hollow, New York",
      "locations": [
        {
          "city": "Sleepy Hollow",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04804098"
    },
    {
      "nct_id": "NCT04332211",
      "title": "Pseudoephedrine Prophylaxis for Prevention of Middle Ear Barotrauma in Hyperbaric Oxygen Therapy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Barotrauma;Ear"
      ],
      "interventions": [
        {
          "name": "Hyperbaric Oxygen Therapy",
          "type": "PROCEDURE"
        },
        {
          "name": "Pseudoephedrine 60 MG",
          "type": "DRUG"
        },
        {
          "name": "Placebo oral tablet",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DRUG"
      ],
      "sponsor": "University of Maryland, Baltimore",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 105,
      "start_date": "2021-05-01",
      "completion_date": "2023-07-12",
      "has_results": true,
      "last_update_posted_date": "2025-01-08",
      "last_synced_at": "2026-05-22T09:04:57.964Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04332211"
    },
    {
      "nct_id": "NCT04776967",
      "title": "Effect of Total Compression Time and Rate (Slope) on Incidence of Symptomatic ETD and MEB: A Phase II Prospective Study.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Eustachian Tube Dysfunction",
        "Middle Ear Barotrauma",
        "Middle Ear Disease",
        "Middle Ear; Injury",
        "Pressure Injury",
        "Ear Barotrauma"
      ],
      "interventions": [
        {
          "name": "Hyperbaric Compression Profile",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Northwell Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 300,
      "start_date": "2014-09-08",
      "completion_date": "2021-02-28",
      "has_results": false,
      "last_update_posted_date": "2021-08-19",
      "last_synced_at": "2026-05-22T09:04:57.964Z",
      "location_count": 1,
      "location_summary": "Sleepy Hollow, New York",
      "locations": [
        {
          "city": "Sleepy Hollow",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04776967"
    },
    {
      "nct_id": "NCT05697328",
      "title": "Barotrauma in Hyperbaric Oxygen Therapy",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Barotrauma"
      ],
      "interventions": [
        {
          "name": "Pseudoephedrine Pill",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "John Muir Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 90,
      "start_date": "2023-01-31",
      "completion_date": "2026-07",
      "has_results": false,
      "last_update_posted_date": "2025-08-27",
      "last_synced_at": "2026-05-22T09:04:57.964Z",
      "location_count": 1,
      "location_summary": "Walnut Creek, California",
      "locations": [
        {
          "city": "Walnut Creek",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05697328"
    },
    {
      "nct_id": "NCT04726306",
      "title": "Diagnostic Precision and Accuracy Using the Teed Scoring System Versus the O'Neill Grading System",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Otic Barotrauma",
        "Pressure Injury",
        "Ear Injury",
        "Barotitis",
        "Barotrauma"
      ],
      "interventions": [
        {
          "name": "Otic Barotrauma Grading System",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Northwell Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 30,
      "start_date": "2023-02-01",
      "completion_date": "2025-03-31",
      "has_results": false,
      "last_update_posted_date": "2024-10-24",
      "last_synced_at": "2026-05-22T09:04:57.964Z",
      "location_count": 1,
      "location_summary": "Sleepy Hollow, New York",
      "locations": [
        {
          "city": "Sleepy Hollow",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04726306"
    },
    {
      "nct_id": "NCT01976429",
      "title": "Gas Supply, Demand and Middle Ear Gas Balance -- Fly/Dive Simulation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Middle-ear Barotrauma"
      ],
      "interventions": [
        {
          "name": "flight/diving simulation",
          "type": "OTHER"
        },
        {
          "name": "ET function testing at ambient pressure",
          "type": "OTHER"
        },
        {
          "name": "nasal video-endoscopy",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "10 Years to 50 Years"
      },
      "enrollment_count": 92,
      "start_date": "2014-12-02",
      "completion_date": "2018-12-04",
      "has_results": false,
      "last_update_posted_date": "2019-08-07",
      "last_synced_at": "2026-05-22T09:04:57.964Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01976429"
    }
  ]
}