{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Mitochondrial+Encephalomyopathy%2C+Lactic+Acidosis+and+Stroke-like+Episodes+%28MELAS%29", "query": { "condition": "Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS)" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 7, "total_pages": 1, "next_page_url": null, "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-05-22T01:51:04.989Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT06402123", "title": "A Phase 2b Study of Zagociguat in Patients With MELAS", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)" ], "interventions": [ { "name": "zagociguat 15mg", "type": "DRUG" }, { "name": "zagociguat 30mg", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Tisento Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 43, "start_date": "2024-09-10", "completion_date": "2026-06-20", "has_results": false, "last_update_posted_date": "2026-03-25", "last_synced_at": "2026-05-22T01:51:04.989Z", "location_count": 10, "location_summary": "La Jolla, California • Aurora, Colorado • Atlanta, Georgia + 5 more", "locations": [ { "city": "La Jolla", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT06402123" }, { "nct_id": "NCT06961344", "title": "An Open-label Extension Safety Study of MELAS Patients Who Completed TIS6463-203 (PRIZM)", "overall_status": "ENROLLING_BY_INVITATION", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)" ], "interventions": [ { "name": "zagociguat 15mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Tisento Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 44, "start_date": "2025-08-18", "completion_date": "2028-07", "has_results": false, "last_update_posted_date": "2026-05-04", "last_synced_at": "2026-05-22T01:51:04.989Z", "location_count": 9, "location_summary": "La Jolla, California • Aurora, Colorado • Atlanta, Georgia + 5 more", "locations": [ { "city": "La Jolla", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT06961344" }, { "nct_id": "NCT00887562", "title": "Study of Idebenone in the Treatment of Mitochondrial Encephalopathy Lactic Acidosis & Stroke-like Episodes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "MELAS Syndrome" ], "interventions": [ { "name": "Idebenone", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Michio Hirano", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "8 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "8 Years to 65 Years" }, "enrollment_count": 27, "start_date": "2009-05", "completion_date": "2012-07", "has_results": true, "last_update_posted_date": "2016-10-26", "last_synced_at": "2026-05-22T01:51:04.989Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT00887562" }, { "nct_id": "NCT03952234", "title": "L-Citrulline Dose Finding Safety Study in MELAS", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "MELAS Syndrome" ], "interventions": [ { "name": "L-Citrulline", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Baylor College of Medicine", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 10, "start_date": "2021-04-22", "completion_date": "2024-06-01", "has_results": false, "last_update_posted_date": "2024-06-26", "last_synced_at": "2026-05-22T01:51:04.989Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT03952234" }, { "nct_id": "NCT06451757", "title": "KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Mitochondrial Diseases", "Maternally Inherited Diabetes and Deafness (MIDD)", "Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS)", "Mitochondrial DNA tRNALeu(UUR) m.3243A