{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Mitral+Regurgitation&page=2",
    "query": {
      "condition": "Mitral Regurgitation",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Mitral+Regurgitation&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-07T15:03:43.962Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04343313",
      "title": "The Half Moon Transcatheter Mitral Valve Repair (TMVr) Pilot Study",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mitral Valve Insufficiency"
      ],
      "interventions": [
        {
          "name": "Half Moon TMVr System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Half Moon Medical",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "95 Years",
        "sex": "ALL",
        "summary": "21 Years to 95 Years"
      },
      "enrollment_count": 30,
      "start_date": "2020-12-08",
      "completion_date": "2029-12-31",
      "has_results": false,
      "last_update_posted_date": "2024-01-12",
      "last_synced_at": "2026-06-07T15:03:43.962Z",
      "location_count": 5,
      "location_summary": "New York, New York • The Bronx, New York • Cleveland, Ohio + 2 more",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "The Bronx",
          "state": "New York"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        },
        {
          "city": "Harrisburg",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04343313"
    },
    {
      "nct_id": "NCT02604745",
      "title": "Degenerative Mitral Regurgitation in Intermediate Risk Patients",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Mitral Valve Insufficiency",
        "Mitral Regurgitation"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Northwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "65 Years to 99 Years"
      },
      "enrollment_count": 13,
      "start_date": "2016-03",
      "completion_date": "2021-01",
      "has_results": false,
      "last_update_posted_date": "2021-04-01",
      "last_synced_at": "2026-06-07T15:03:43.962Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02604745"
    },
    {
      "nct_id": "NCT04029337",
      "title": "An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mitral Regurgitation"
      ],
      "interventions": [
        {
          "name": "Transcatheter Mitral Valve Replacement",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "HighLife SAS",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2020-07-14",
      "completion_date": "2030-12",
      "has_results": false,
      "last_update_posted_date": "2025-03-17",
      "last_synced_at": "2026-06-07T15:03:43.962Z",
      "location_count": 10,
      "location_summary": "Tucson, Arizona • Los Angeles, California • Atlanta, Georgia + 7 more",
      "locations": [
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04029337"
    },
    {
      "nct_id": "NCT05332782",
      "title": "Outcomes of Patients tReated wIth Mitral Transcatheter Edge-to-edge Repair for Primary Mitral Regurgitation Registry",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Mitral Regurgitation"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Universitätsklinikum Hamburg-Eppendorf",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 2000,
      "start_date": "2022-03-01",
      "completion_date": "2026-01-01",
      "has_results": false,
      "last_update_posted_date": "2022-04-18",
      "last_synced_at": "2026-06-07T15:03:43.962Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05332782"
    },
    {
      "nct_id": "NCT02677740",
      "title": "Mechanisms of Non-Invasive Neuromodulation Interventions: Influence on Human Neurochemistry and Functional Connectivity",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Non-invasive Neuromodulation in Healthy Subjects"
      ],
      "interventions": [
        {
          "name": "Inhibitory rTMS (1 Hz)",
          "type": "DEVICE"
        },
        {
          "name": "Excitatory rTMS (5 Hz)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "40 Years",
        "sex": "MALE",
        "summary": "21 Years to 40 Years · Male only"
      },
      "enrollment_count": 8,
      "start_date": "2016-08-29",
      "completion_date": "2017-03-19",
      "has_results": true,
      "last_update_posted_date": "2019-11-18",
      "last_synced_at": "2026-06-07T15:03:43.962Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02677740"
    },
    {
      "nct_id": "NCT02124590",
      "title": "The Effect of Oral Carnitine Supplementation on MRS-derived Mitochondrial Function",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Elderly",
        "Pre-diabetic"
      ],
      "interventions": [
        {
          "name": "Acute Exercise",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "60 Years to 80 Years"
      },
      "enrollment_count": 14,
      "start_date": "2014-06",
      "completion_date": "2014-12",
      "has_results": false,
      "last_update_posted_date": "2015-06-17",
      "last_synced_at": "2026-06-07T15:03:43.962Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02124590"
    },
    {
      "nct_id": "NCT03254342",
      "title": "MRS and Medication Response: A Pilot Study",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Major Depressive Disorder",
        "Major Depressive Episode",
        "Major Depressive Disorder, Recurrent",
        "Major Depression Mild",
        "Major Depression Moderate",
        "Major Depression Severe"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "21 Years to 75 Years"
      },
      "enrollment_count": 3,
      "start_date": "2013-08-06",
      "completion_date": "2020-08-31",
      "has_results": false,
      "last_update_posted_date": "2021-08-19",
      "last_synced_at": "2026-06-07T15:03:43.962Z",
      "location_count": 1,
      "location_summary": "Stanford, California",
      "locations": [
        {
          "city": "Stanford",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03254342"
    },
    {
      "nct_id": "NCT03016975",
      "title": "Edwards Cardioband System ACTIVE Pivotal Clinical Trial (ACTIVE)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Functional Mitral Regurgitation",
        "Mitral Regurgitation",
        "Mitral Insufficiency"
      ],
      "interventions": [
        {
          "name": "Edwards Cardioband System",
          "type": "DEVICE"
        },
        {
          "name": "Guideline Directed Medical Therapy",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "DRUG"
      ],
      "sponsor": "Edwards Lifesciences",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 12,
      "start_date": "2017-06-01",
      "completion_date": "2022-09-20",
      "has_results": true,
      "last_update_posted_date": "2023-11-30",
      "last_synced_at": "2026-06-07T15:03:43.962Z",
      "location_count": 24,
      "location_summary": "Los Angeles, California • Palo Alto, California • Aurora, Colorado + 18 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03016975"
    },
    {
      "nct_id": "NCT04051411",
      "title": "The Effects of Degenerative Mitral Regurgitation on Cardiac Structure and Function, Symptoms, and Exercise Capacity",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Mitral Regurgitation"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Atlantic Health System",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2019-08-07",
      "completion_date": "2024-01",
      "has_results": false,
      "last_update_posted_date": "2019-08-21",
      "last_synced_at": "2026-06-07T15:03:43.962Z",
      "location_count": 1,
      "location_summary": "Morristown, New Jersey",
      "locations": [
        {
          "city": "Morristown",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04051411"
    },
    {
      "nct_id": "NCT01940120",
      "title": "EVEREST II Pivotal Study High Risk Registry (HRR)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mitral Valve Insufficiency",
        "Mitral Valve Regurgitation",
        "Mitral Valve Incompetence",
        "Mitral Regurgitation",
        "Mitral Insufficiency"
      ],
      "interventions": [
        {
          "name": "Percutaneous mitral valve repair using MitraClip implant",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Abbott Medical Devices",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 78,
      "start_date": "2007-02",
      "completion_date": "2013-02",
      "has_results": true,
      "last_update_posted_date": "2018-11-07",
      "last_synced_at": "2026-06-07T15:03:43.962Z",
      "location_count": 2,
      "location_summary": "Evanston, Illinois • Indianapolis, Indiana",
      "locations": [
        {
          "city": "Evanston",
          "state": "Illinois"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01940120"
    }
  ]
}