{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Moderate+Cognitive+Impairment&page=2", "query": { "condition": "Moderate Cognitive Impairment", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Moderate+Cognitive+Impairment&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-07-23T21:01:45.492Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00506415", "title": "Comparative Efficacy, Safety, and Tolerability of Rivastigmine 10 and 15 cm^2 Patch in Patients With Alzheimer's Disease (AD) Showing Cognitive Decline", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Alzheimer Disease" ], "interventions": [ { "name": "Rivastigmine 5 cm^2", "type": "DRUG" }, { "name": "Rivastigmine 10 cm^2", "type": "DRUG" }, { "name": "Rivastigmine 15 cm^2", "type": "DRUG" }, { "name": "Placebo to 15 cm^2 patch", "type": "DRUG" }, { "name": "Placebo to 10 cm^2 patch", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "50 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "50 Years to 85 Years" }, "enrollment_count": 1584, "start_date": "2007-06", "completion_date": "2011-05", "has_results": true, "last_update_posted_date": "2012-09-19", "last_synced_at": "2026-07-23T21:01:45.492Z", "location_count": 65, "location_summary": "Birmingham, Alabama • Gilbert, Arizona • Phoenix, Arizona + 61 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Gilbert", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Sun City", "state": "Arizona" }, { "city": "Anaheim", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00506415" }, { "nct_id": "NCT05117502", "title": "Foundations in Developing Precision Cognitive Restoration", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Moderate Cognitive Impairment", "Traumatic Brain Injury", "Stroke" ], "interventions": [ { "name": "intermittent Theta Burst Stimulation", "type": "DEVICE" }, { "name": "Placebo intermittent Theta Burst Stimulation", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "VA Office of Research and Development", "sponsor_class": "FED", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 0, "start_date": "2022-02-24", "completion_date": "2023-09-30", "has_results": false, "last_update_posted_date": "2024-08-29", "last_synced_at": "2026-07-23T21:01:45.492Z", "location_count": 1, "location_summary": "Hines, Illinois", "locations": [ { "city": "Hines", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT05117502" }, { "nct_id": "NCT00876863", "title": "Randomized, Controlled Study Evaluating CERE-110 in Subjects With Mild to Moderate Alzheimer's Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Alzheimer's Disease" ], "interventions": [ { "name": "CERE-110: Adeno-Associated Virus injection Surgery", "type": "DRUG" }, { "name": "Placebo Surgery", "type": "PROCEDURE" } ], "intervention_types": [ "DRUG", "PROCEDURE" ], "sponsor": "Sangamo Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "55 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "55 Years to 80 Years" }, "enrollment_count": 49, "start_date": "2008-11", "completion_date": "2015-08-13", "has_results": false, "last_update_posted_date": "2020-12-21", "last_synced_at": "2026-07-23T21:01:45.492Z", "location_count": 10, "location_summary": "Birmingham, Alabama • Los Angeles, California • San Diego, California + 7 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Los Angeles", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Atlanta", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT00876863" }, { "nct_id": "NCT04500847", "title": "Repurposing Nucleoside Reverse Transcriptase Inhibitors for Treatment of AD", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Alzheimer Disease, Early Onset", "Mild Cognitive Impairment", "Moderate Dementia" ], "interventions": [ { "name": "Emtriva Capsule", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Butler Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "50 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "50 Years to 85 Years" }, "enrollment_count": 35, "start_date": "2021-12-17", "completion_date": "2026-03-31", "has_results": false, "last_update_posted_date": "2025-05-04", "last_synced_at": "2026-07-23T21:01:45.492Z", "location_count": 2, "location_summary": "Los Angeles, California • Providence, Rhode Island", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Providence", "state": "Rhode Island" } ], "official_url": "https://clinicaltrials.gov/study/NCT04500847" }, { "nct_id": "NCT05466422", "title": "A Study of MK-2214 in Adults With Mild Cognitive Impairment or Mild-to-Moderate Alzheimer's Disease (MK-2214-002)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Alzheimer Disease" ], "interventions": [ { "name": "MK-2214", "type": "BIOLOGICAL" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "Merck Sharp & Dohme LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "50 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "50 Years to 80 Years" }, "enrollment_count": 34, "start_date": "2022-09-20", "completion_date": "2025-07-03", "has_results": false, "last_update_posted_date": "2025-08-27", "last_synced_at": "2026-07-23T21:01:45.492Z", "location_count": 12, "location_summary": "Glendale, California • Los Alamitos, California • Orange, California + 9 more", "locations": [ { "city": "Glendale", "state": "California" }, { "city": "Los Alamitos", "state": "California" }, { "city": "Orange", "state": "California" }, { "city": "Hallandale", "state": "Florida" }, { "city": "Hollywood", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT05466422" }, { "nct_id": "NCT00454870", "title": "Safety and Efficacy of MEM 3454 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Alzheimer's Disease" ], "interventions": [ { "name": "MEM 3454", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Memory Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "50 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "50 Years to 80 Years" }, "enrollment_count": 80, "start_date": "2007-02", "completion_date": "2007-10", "has_results": false, "last_update_posted_date": "2008-05-06", "last_synced_at": "2026-07-23T21:01:45.492Z", "location_count": 7, "location_summary": "Phoenix, Arizona • Glendale, California • Atlanta, Georgia + 3 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Glendale", "state": "California" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Wichita", "state": "Kansas" }, { "city": "Wichita", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT00454870" }, { "nct_id": "NCT00611533", "title": "Placebo Controlled Study of Atomoxetine in the Treatment of Mild to Moderate Cognitive Difficulties in Menopausal Women", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Menopause", "Cognitive Disturbances" ], "interventions": [ { "name": "atomoxetine", "type": "DRUG" }, { "name": "placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Pennsylvania", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "45 Years", "maximum_age": "60 Years", "sex": "FEMALE", "summary": "45 Years to 60 Years · Female only" }, "enrollment_count": 16, "start_date": "2004-05", "completion_date": "2008-04", "has_results": true, "last_update_posted_date": "2017-04-17", "last_synced_at": "2026-07-23T21:01:45.492Z", "location_count": 1, "location_summary": "New Haven, Connecticut", "locations": [ { "city": "New Haven", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT00611533" }, { "nct_id": "NCT06584357", "title": "Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and Amyloid PET Imaging in Older Participants Who Are Cognitively Normal (CN), Have Mild Cognitive Impairment (MCI), or Have Mild-to-Moderate AD Dementia", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Mild Cognitive Impairment", "Alzheimer's Disease", "Alzheimer's Disease, Early Onset", "Memory Loss", "Memory Disorders", "Memory Impairment" ], "interventions": [ { "name": "Biomarker Data Collection", "type": "OTHER" }, { "name": "MK6240", "type": "RADIATION" } ], "intervention_types": [ "OTHER", "RADIATION" ], "sponsor": "GAP Innovations, PBC", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "60 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "60 Years to 90 Years" }, "enrollment_count": 1200, "start_date": "2024-09-26", "completion_date": "2028-07", "has_results": false, "last_update_posted_date": "2026-04-15", "last_synced_at": "2026-07-23T21:01:45.492Z", "location_count": 22, "location_summary": "Atlantis, Florida • Aventura, Florida • Clermont, Florida + 19 more", "locations": [ { "city": "Atlantis", "state": "Florida" }, { "city": "Aventura", "state": "Florida" }, { "city": "Clermont", "state": "Florida" }, { "city": "Delray Beach", "state": "Florida" }, { "city": "Fort Myers", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT06584357" }, { "nct_id": "NCT04971733", "title": "A Study to Assess Safety and Target Engagement of E2814 in Participants With Mild to Moderate Cognitive Impairment Due to Dominantly Inherited Alzheimer's Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Alzheimer Disease" ], "interventions": [ { "name": "E2814", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Eisai Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 8, "start_date": "2021-06-28", "completion_date": "2024-05-24", "has_results": true, "last_update_posted_date": "2025-06-10", "last_synced_at": "2026-07-23T21:01:45.492Z", "location_count": 2, "location_summary": "La Jolla, California • Indianapolis, Indiana", "locations": [ { "city": "La Jolla", "state": "California" }, { "city": "Indianapolis", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT04971733" }, { "nct_id": "NCT06245031", "title": "Extension to a Pivotal Study of Sensory Stimulation in Alzheimer's Disease (OLE Hope Study, CA-0015)", "overall_status": "ENROLLING_BY_INVITATION", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Alzheimer Disease", "Cognitive Impairment", "Mild Cognitive Impairment", "Dementia, Mild", "Dementia Moderate", "Dementia Alzheimers", "Dementia of Alzheimer Type", "AD" ], "interventions": [ { "name": "Sensory Stimulation System (GS120) - Active", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Cognito Therapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "50 Years", "maximum_age": "92 Years", "sex": "ALL", "summary": "50 Years to 92 Years" }, "enrollment_count": 402, "start_date": "2024-02-29", "completion_date": "2027-03", "has_results": false, "last_update_posted_date": "2024-05-07", "last_synced_at": "2026-07-23T21:01:45.492Z", "location_count": 53, "location_summary": "Phoenix, Arizona • Sun City, Arizona • Anaheim, California + 48 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Sun City", "state": "Arizona" }, { "city": "Anaheim", "state": "California" }, { "city": "Costa Mesa", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06245031" } ] }