{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Moderate+to+Severe+Crohn%27s+Disease", "query": { "condition": "Moderate to Severe Crohn's Disease" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 154, "total_pages": 16, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Moderate+to+Severe+Crohn%27s+Disease&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-10-20T05:01:45.404Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01224171", "title": "Study of Vedolizumab in Patients With Moderate to Severe Crohn's Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Crohn's Disease" ], "interventions": [ { "name": "vedolizumab", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Millennium Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 416, "start_date": "2010-11", "completion_date": "2012-04", "has_results": true, "last_update_posted_date": "2014-07-21", "last_synced_at": "2026-10-20T05:01:45.404Z", "location_count": 40, "location_summary": "Lafayette, Colorado • Hamden, Connecticut • Gainesville, Florida + 36 more", "locations": [ { "city": "Lafayette", "state": "Colorado" }, { "city": "Hamden", "state": "Connecticut" }, { "city": "Gainesville", "state": "Florida" }, { "city": "Miami", "state": "Florida" }, { "city": "Winter Park", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01224171" }, { "nct_id": "NCT00783692", "title": "Study of Vedolizumab (MLN0002) in Patients With Moderate to Severe Crohn's Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Crohn's Disease" ], "interventions": [ { "name": "vedolizumab", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Millennium Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 1116, "start_date": "2008-12", "completion_date": "2012-05", "has_results": true, "last_update_posted_date": "2014-07-21", "last_synced_at": "2026-10-20T05:01:45.404Z", "location_count": 110, "location_summary": "Birmingham, Alabama • Los Angeles, California • Montebello, California + 91 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Los Angeles", "state": "California" }, { "city": "Montebello", "state": "California" }, { "city": "Sacramento", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00783692" }, { "nct_id": "NCT01393626", "title": "A Study To Investigate Safety And Efficacy Of CP-690,550 For Induction Therapy In Subjects With Moderate To Severe Crohn's Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Crohn's Disease" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "CP-690,550", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 280, "start_date": "2011-10", "completion_date": "2015-03", "has_results": true, "last_update_posted_date": "2017-04-28", "last_synced_at": "2026-10-20T05:01:45.404Z", "location_count": 73, "location_summary": "Anaheim, California • Oceanside, California • Poway, California + 42 more", "locations": [ { "city": "Anaheim", "state": "California" }, { "city": "Anaheim", "state": "California" }, { "city": "Anaheim", "state": "California" }, { "city": "Oceanside", "state": "California" }, { "city": "Poway", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01393626" }, { "nct_id": "NCT06819891", "title": "A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Moderately to Severely Active Crohns Disease" ], "interventions": [ { "name": "Afimkibart", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "16 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "16 Years to 80 Years" }, "enrollment_count": 425, "start_date": "2025-05-12", "completion_date": "2033-04-30", "has_results": false, "last_update_posted_date": "2026-09-28", "last_synced_at": "2026-10-20T05:01:45.404Z", "location_count": 61, "location_summary": "Dothan, Alabama • Glendale, Arizona • Lancaster, California + 55 more", "locations": [ { "city": "Dothan", "state": "Alabama" }, { "city": "Glendale", "state": "Arizona" }, { "city": "Lancaster", "state": "California" }, { "city": "Newport Beach", "state": "California" }, { "city": "Pomona", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06819891" }, { "nct_id": "NCT07499232", "title": "A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Crohn's Disease", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Crohn Disease" ], "interventions": [ { "name": "Guselkumab", "type": "DRUG" }, { "name": "Risankizumab", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 530, "start_date": "2026-04-21", "completion_date": "2030-12-11", "has_results": false, "last_update_posted_date": "2026-09-25", "last_synced_at": "2026-10-20T05:01:45.404Z", "location_count": 39, "location_summary": "Dothan, Alabama • Mobile, Alabama • Anaheim, California + 32 more", "locations": [ { "city": "Dothan", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" }, { "city": "Anaheim", "state": "California" }, { "city": "Lancaster", "state": "California" }, { "city": "Los Alamitos", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT07499232" }, { "nct_id": "NCT06456593", "title": "Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Moderately to Severely Active Crohn Disease" ], "interventions": [ { "name": "Obefazimod", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Abivax S.A.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 212, "start_date": "2024-10-30", "completion_date": "2028-04", "has_results": false, "last_update_posted_date": "2026-04-27", "last_synced_at": "2026-10-20T05:01:45.404Z", "location_count": 43, "location_summary": "Fairhope, Alabama • Scottsdale, Arizona • Sun City, Arizona + 40 more", "locations": [ { "city": "Fairhope", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Sun City", "state": "Arizona" }, { "city": "Irvine", "state": "California" }, { "city": "Murrieta", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06456593" }, { "nct_id": "NCT00102921", "title": "Safety and Activity Study of an Oral Medication to Treat Moderate to Severe Crohn's Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Crohn Disease" ], "interventions": [ { "name": "CCX282-B", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Amgen", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 70, "start_date": "2004-08", "completion_date": "2005-12", "has_results": false, "last_update_posted_date": "2025-03-06", "last_synced_at": "2026-10-20T05:01:45.404Z", "location_count": 14, "location_summary": "Los Angeles, California • Golden, Colorado • Littleton, Colorado + 11 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Golden", "state": "Colorado" }, { "city": "Littleton", "state": "Colorado" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT00102921" }, { "nct_id": "NCT03467958", "title": "An Extension Study of Oral Ozanimod for Moderately to Severely Active Crohn's Disease", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Crohn Disease" ], "interventions": [ { "name": "Ozanimod", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Celgene", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 854, "start_date": "2018-08-24", "completion_date": "2024-10-31", "has_results": true, "last_update_posted_date": "2025-09-17", "last_synced_at": "2026-10-20T05:01:45.404Z", "location_count": 190, "location_summary": "Peoria, Arizona • Scottsdale, Arizona • North Little Rock, Arkansas + 142 more", "locations": [ { "city": "Peoria", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "North Little Rock", "state": "Arkansas" }, { "city": "Camarillo", "state": "California" }, { "city": "Chula Vista", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03467958" }, { "nct_id": "NCT00042055", "title": "CP-461 for the Treatment of Crohn's Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Crohn's Disease" ], "interventions": [ { "name": "CP-461", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Astellas Pharma Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 30, "start_date": "2002-07", "completion_date": "2003-09", "has_results": false, "last_update_posted_date": "2011-10-17", "last_synced_at": "2026-10-20T05:01:45.404Z", "location_count": 10, "location_summary": "Birmingham, Alabama • Orange, California • Gainesville, Florida + 7 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Orange", "state": "California" }, { "city": "Gainesville", "state": "Florida" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT00042055" }, { "nct_id": "NCT06937099", "title": "Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Crohn's Disease", "Obesity or Overweight" ], "interventions": [ { "name": "Mirikizumab", "type": "DRUG" }, { "name": "Tirzepatide", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Eli Lilly and Company", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 290, "start_date": "2025-06-26", "completion_date": "2028-05", "has_results": false, "last_update_posted_date": "2026-10-07", "last_synced_at": "2026-10-20T05:01:45.404Z", "location_count": 35, "location_summary": "Dothan, Alabama • Anaheim, California • Beverly Hills, California + 29 more", "locations": [ { "city": "Dothan", "state": "Alabama" }, { "city": "Anaheim", "state": "California" }, { "city": "Beverly Hills", "state": "California" }, { "city": "Los Alamitos", "state": "California" }, { "city": "Northridge", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06937099" } ] }