{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Motor+Fluctuations",
    "query": {
      "condition": "Motor Fluctuations"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 59,
    "total_pages": 6,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Motor+Fluctuations&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-23T06:48:13.182Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03670953",
      "title": "A Study to Evaluate the Safety and Efficacy of IPX203 in Parkinson's Disease Participants With Motor Fluctuations",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Parkinson's Disease (Disorder)"
      ],
      "interventions": [
        {
          "name": "IR CD-LD",
          "type": "DRUG"
        },
        {
          "name": "IPX203 ER CD-LD",
          "type": "DRUG"
        },
        {
          "name": "Placebo Matching IPX203",
          "type": "OTHER"
        },
        {
          "name": "Placebo Matching IR CD-LD",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Impax Laboratories, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 630,
      "start_date": "2018-11-06",
      "completion_date": "2021-06-15",
      "has_results": true,
      "last_update_posted_date": "2023-02-09",
      "last_synced_at": "2026-07-23T06:48:13.182Z",
      "location_count": 56,
      "location_summary": "Phoenix, Arizona • Little Rock, Arkansas • Loma Linda, California + 46 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Loma Linda",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03670953"
    },
    {
      "nct_id": "NCT04380142",
      "title": "Study Comparing Continuous Subcutaneous Infusion Of ABBV-951 With Oral Carbidopa/Levodopa Tablets For Treatment Of Motor Fluctuations In Adult Participants With Advanced Parkinson's Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Parkinson's Disease (PD)"
      ],
      "interventions": [
        {
          "name": "ABBV-951",
          "type": "DRUG"
        },
        {
          "name": "Placebo for Levodopa/Carbidopa (LD/CD)",
          "type": "DRUG"
        },
        {
          "name": "Levodopa/Carbidopa (LD/CD)",
          "type": "DRUG"
        },
        {
          "name": "Placebo for ABBV-951",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "AbbVie",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "30 Years and older"
      },
      "enrollment_count": 174,
      "start_date": "2020-10-19",
      "completion_date": "2021-09-29",
      "has_results": true,
      "last_update_posted_date": "2022-11-18",
      "last_synced_at": "2026-07-23T06:48:13.182Z",
      "location_count": 70,
      "location_summary": "Birmingham, Alabama • Mobile, Alabama • Phoenix, Arizona + 62 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Mobile",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04380142"
    },
    {
      "nct_id": "NCT01171313",
      "title": "A Efficacy, Safety and Pharmacokinetic Study of XP21279 and Sinemet® in Parkinson's Disease Subjects",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Parkinson's Disease"
      ],
      "interventions": [
        {
          "name": "XP21279 and carbidopa (experimental)",
          "type": "DRUG"
        },
        {
          "name": "Sinemet (comparator)",
          "type": "DRUG"
        },
        {
          "name": "Placebo for XP21279 and carbidopa",
          "type": "DRUG"
        },
        {
          "name": "Placebo for Sinemet",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "XenoPort, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "30 Years to 80 Years"
      },
      "enrollment_count": 35,
      "start_date": "2010-07",
      "completion_date": "2011-12",
      "has_results": false,
      "last_update_posted_date": "2021-02-18",
      "last_synced_at": "2026-07-23T06:48:13.182Z",
      "location_count": 12,
      "location_summary": "Phoenix, Arizona • Little Rock, Arkansas • Long Beach, California + 9 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "Sunnyvale",
          "state": "California"
        },
        {
          "city": "Naples",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01171313"
    },
    {
      "nct_id": "NCT00406588",
      "title": "SLV308 for Treatment of Patients With Parkinson's Disease Experiencing Motor Fluctuations",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Advanced Stage Parkinson's Disease"
      ],
      "interventions": [
        {
          "name": "Levodopa (Pardoprunox)",
          "type": "DRUG"
        },
        {
          "name": "Placebo Comparator",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Solvay Pharmaceuticals",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "30 Years and older"
      },
      "enrollment_count": 295,
      "start_date": "2007-03",
      "completion_date": "2008-05",
      "has_results": false,
      "last_update_posted_date": "2015-02-27",
      "last_synced_at": "2026-07-23T06:48:13.182Z",
      "location_count": 15,
      "location_summary": "Birmingham, Alabama • La Jolla, California • San Francisco, California + 12 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Fort Lauderdale",
          "state": "Florida"
        },
        {
          "city": "Gainsville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00406588"
    },
    {
      "nct_id": "NCT03185481",
      "title": "Safety and Tolerability of PF-06649751 in Parkinson's Disease Patients With Motor Fluctuations",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Parkinson's Disease With Motor Fluctuations"
      ],
      "interventions": [
        {
          "name": "1 mg QD to 15 mg QD PF-06649751",
          "type": "DRUG"
        },
        {
          "name": "3 mg QD to 15 mg QD PF-06649751",
          "type": "DRUG"
        },
        {
          "name": "7 mg QD to 15 mg QD PF-06649751",
          "type": "DRUG"
        },
        {
          "name": "15 mg QD PF-06649751",
          "type": "DRUG"
        },
        {
          "name": "1 mg QD to 7 mg QD PF-06649751 (if de-escalated in parent study)",
          "type": "DRUG"
        },
        {
          "name": "3 mg QD to 7 mg QD PF-06649751 (de-escalated in parent study)",
          "type": "DRUG"
        },
        {
          "name": "7 mg QD to 7 mg QD PF-06649751 (de-escalated in parent study)",
          "type": "DRUG"
        },
        {
          "name": "15 mg QD de-escalated to 7 mg QD PF-06649751 in parent study remain at 7 mg QD",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Pfizer",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "87 Years",
        "sex": "ALL",
        "summary": "40 Years to 87 Years"
      },
      "enrollment_count": 5,
      "start_date": "2017-07-06",
      "completion_date": "2017-10-25",
      "has_results": true,
      "last_update_posted_date": "2019-04-12",
      "last_synced_at": "2026-07-23T06:48:13.182Z",
      "location_count": 9,
      "location_summary": "Newport Beach, California • Fairfield, Connecticut • Boca Raton, Florida + 5 more",
      "locations": [
        {
          "city": "Newport Beach",
          "state": "California"
        },
        {
          "city": "Fairfield",
          "state": "Connecticut"
        },
        {
          "city": "Boca Raton",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Marlton",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03185481"
    },
    {
      "nct_id": "NCT01777555",
      "title": "Efficacy and Safety Study of Inhaled CVT 301 in Parkinson's Disease Patients for Treatment of OFF Episodes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Idiopathic Parkinson's Disease"
      ],
      "interventions": [
        {
          "name": "CVT-301",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Acorda Therapeutics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "30 Years to 80 Years"
      },
      "enrollment_count": 89,
      "start_date": "2013-04",
      "completion_date": "2014-01",
      "has_results": false,
      "last_update_posted_date": "2018-08-08",
      "last_synced_at": "2026-07-23T06:48:13.182Z",
      "location_count": 13,
      "location_summary": "Little Rock, Arkansas • Boca Raton, Florida • Port Charlotte, Florida + 10 more",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Boca Raton",
          "state": "Florida"
        },
        {
          "city": "Port Charlotte",
          "state": "Florida"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        },
        {
          "city": "Kansas City",
          "state": "Kansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01777555"
    },
    {
      "nct_id": "NCT02005029",
      "title": "Erythromycin in Parkinson's Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Parkinson's Disease",
        "Levodopa"
      ],
      "interventions": [
        {
          "name": "Erythromycin",
          "type": "DRUG"
        },
        {
          "name": "placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Virginia Commonwealth University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 18,
      "start_date": "2013-04",
      "completion_date": "2015-06",
      "has_results": true,
      "last_update_posted_date": "2017-02-03",
      "last_synced_at": "2026-07-23T06:48:13.182Z",
      "location_count": 1,
      "location_summary": "Richmond, Virginia",
      "locations": [
        {
          "city": "Richmond",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02005029"
    },
    {
      "nct_id": "NCT00914602",
      "title": "An Exploratory Study of XP21279 (With Lodosyn®) and Sinemet® in Parkinson's Disease Subjects",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Parkinson's Disease"
      ],
      "interventions": [
        {
          "name": "Sinemet 25-100 Oral Tablet",
          "type": "DRUG"
        },
        {
          "name": "XP21279",
          "type": "DRUG"
        },
        {
          "name": "Carbidopa Pill",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "XenoPort, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "30 Years to 75 Years"
      },
      "enrollment_count": 14,
      "start_date": "2009-05",
      "completion_date": "2010-01",
      "has_results": false,
      "last_update_posted_date": "2021-05-05",
      "last_synced_at": "2026-07-23T06:48:13.182Z",
      "location_count": 2,
      "location_summary": "Peoria, Arizona • Bingham Farms, Michigan",
      "locations": [
        {
          "city": "Peoria",
          "state": "Arizona"
        },
        {
          "city": "Bingham Farms",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00914602"
    },
    {
      "nct_id": "NCT02224664",
      "title": "Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PF-06649751 in Parkinson's Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Parkinson's Disease"
      ],
      "interventions": [
        {
          "name": "PF-06649751",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Pfizer",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "30 Years to 80 Years"
      },
      "enrollment_count": 50,
      "start_date": "2014-10",
      "completion_date": "2016-03",
      "has_results": true,
      "last_update_posted_date": "2017-03-27",
      "last_synced_at": "2026-07-23T06:48:13.182Z",
      "location_count": 16,
      "location_summary": "Fountain Valley, California • Long Beach, California • Englewood, Colorado + 10 more",
      "locations": [
        {
          "city": "Fountain Valley",
          "state": "California"
        },
        {
          "city": "Fountain Valley",
          "state": "California"
        },
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "Englewood",
          "state": "Colorado"
        },
        {
          "city": "Lakewood",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02224664"
    },
    {
      "nct_id": "NCT00335153",
      "title": "Levodopa-Carbidopa Intestinal Gel Open-Label Study in Advanced Parkinson's Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Advanced Parkinson's Disease"
      ],
      "interventions": [
        {
          "name": "Levodopa-carbidopa intestinal gel",
          "type": "DRUG"
        },
        {
          "name": "CADD-Legacy® 1400 ambulatory infusion pump",
          "type": "DEVICE"
        },
        {
          "name": "PEG tube",
          "type": "DEVICE"
        },
        {
          "name": "J-tube",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "AbbVie (prior sponsor, Abbott)",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "30 Years and older"
      },
      "enrollment_count": 354,
      "start_date": "2008-01",
      "completion_date": "2012-06",
      "has_results": true,
      "last_update_posted_date": "2015-01-16",
      "last_synced_at": "2026-07-23T06:48:13.182Z",
      "location_count": 31,
      "location_summary": "Birmingham, Alabama • Fountain Valley, California • Los Angeles, California + 25 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Fountain Valley",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Oceanside",
          "state": "California"
        },
        {
          "city": "Englewood",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00335153"
    }
  ]
}