{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Muscle+Tone+Increased&page=2",
    "query": {
      "condition": "Muscle Tone Increased",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Muscle+Tone+Increased&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T14:42:10.806Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03814889",
      "title": "Passive Tactile Stimulation for Stroke Rehabilitation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Stroke",
        "Stroke, Ischemic",
        "Stroke Hemorrhagic",
        "Spasticity as Sequela of Stroke"
      ],
      "interventions": [
        {
          "name": "Vibration pattern",
          "type": "DEVICE"
        },
        {
          "name": "No vibration",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 35,
      "start_date": "2019-05-15",
      "completion_date": "2022-12-31",
      "has_results": true,
      "last_update_posted_date": "2024-04-08",
      "last_synced_at": "2026-07-22T14:42:10.806Z",
      "location_count": 1,
      "location_summary": "Palo Alto, California",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03814889"
    },
    {
      "nct_id": "NCT00282191",
      "title": "Prevalence of Spasticity in Adults With Mental Retardation Living in the Community",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Mental Retardation",
        "Spasticity"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Vanderbilt University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 7,
      "start_date": "2006-08",
      "completion_date": "2007-08",
      "has_results": false,
      "last_update_posted_date": "2008-03-28",
      "last_synced_at": "2026-07-22T14:42:10.806Z",
      "location_count": 1,
      "location_summary": "Davidson County, Tennessee",
      "locations": [
        {
          "city": "Davidson County",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00282191"
    },
    {
      "nct_id": "NCT06027580",
      "title": "Orthosis to Improve Trunk Control in Infants Age 6-18 Months",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cerebral Palsy"
      ],
      "interventions": [
        {
          "name": "SPIO® Core-MAX® Expedition thoracolumbosacral orthosis",
          "type": "DEVICE"
        },
        {
          "name": "Standard Care Therapy option",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Medical College of Wisconsin",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "6 Months",
        "maximum_age": "18 Months",
        "sex": "ALL",
        "summary": "6 Months to 18 Months"
      },
      "enrollment_count": 30,
      "start_date": "2024-02-21",
      "completion_date": "2026-08-06",
      "has_results": false,
      "last_update_posted_date": "2026-01-14",
      "last_synced_at": "2026-07-22T14:42:10.806Z",
      "location_count": 1,
      "location_summary": "Milwaukee, Wisconsin",
      "locations": [
        {
          "city": "Milwaukee",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06027580"
    },
    {
      "nct_id": "NCT06653855",
      "title": "The Effect of Cupping on Spasticity and Function of the Lower Extremity During Rehabilitation After Stroke",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Stroke Gait Rehabilitation"
      ],
      "interventions": [
        {
          "name": "Dry Static Cupping",
          "type": "OTHER"
        },
        {
          "name": "Placebo cupping",
          "type": "OTHER"
        },
        {
          "name": "Standard physical therapy treatment",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Scott Getsoian",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "30 Years to 80 Years"
      },
      "enrollment_count": 30,
      "start_date": "2024-12",
      "completion_date": "2026-01",
      "has_results": false,
      "last_update_posted_date": "2024-12-13",
      "last_synced_at": "2026-07-22T14:42:10.806Z",
      "location_count": 1,
      "location_summary": "Joliet, Illinois",
      "locations": [
        {
          "city": "Joliet",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06653855"
    },
    {
      "nct_id": "NCT00661089",
      "title": "Randomized DB Controlled Trial of Botulinum Toxin A in Hemiplegic Shoulder Pain and Spasticity",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Post-stroke Shoulder Pain and Spasticity"
      ],
      "interventions": [
        {
          "name": "Botulinum Toxin Type A - OnabotulinumtoxinA",
          "type": "DRUG"
        },
        {
          "name": "Placebo (Saline)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Shirley Ryan AbilityLab",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 21,
      "start_date": "2003-09",
      "completion_date": "2010-02",
      "has_results": true,
      "last_update_posted_date": "2020-11-13",
      "last_synced_at": "2026-07-22T14:42:10.806Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00661089"
    },
    {
      "nct_id": "NCT00060957",
      "title": "Botulinum Toxin (BOTOX) for Cerebral Palsy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Cerebral Palsy",
        "Muscle Spasticity"
      ],
      "interventions": [
        {
          "name": "Botulinum toxin type A",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": "12 Years",
        "sex": "ALL",
        "summary": "3 Years to 12 Years"
      },
      "enrollment_count": 40,
      "start_date": "1997-07",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2016-09-26",
      "last_synced_at": "2026-07-22T14:42:10.806Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00060957"
    },
    {
      "nct_id": "NCT04029896",
      "title": "Individual Patient Expanded Access IND of Hope Biosciences Autologous Adipose-derived Mesenchymal Stem Cells for the Treatment of Cerebral Palsy",
      "overall_status": "NO_LONGER_AVAILABLE",
      "study_type": "EXPANDED_ACCESS",
      "phases": [],
      "conditions": [
        "Cerebral Palsy"
      ],
      "interventions": [
        {
          "name": "HB-adMSCs",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Hope Biosciences Research Foundation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": null,
        "sex": "MALE",
        "summary": "3 Years and older · Male only"
      },
      "enrollment_count": null,
      "start_date": null,
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2025-09-29",
      "last_synced_at": "2026-07-22T14:42:10.806Z",
      "location_count": 1,
      "location_summary": "Sugar Land, Texas",
      "locations": [
        {
          "city": "Sugar Land",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04029896"
    },
    {
      "nct_id": "NCT00179114",
      "title": "Vanderbilt University Spasticity Management Program Evaluation Plan",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Spasticity"
      ],
      "interventions": [
        {
          "name": "Botulinum Toxin Type A",
          "type": "DRUG"
        },
        {
          "name": "Intrathecal baclofen administered by the Medtronic SyncroMed(TM) pump (ITB)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Vanderbilt University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2002-08",
      "completion_date": "2006-02",
      "has_results": false,
      "last_update_posted_date": "2007-08-20",
      "last_synced_at": "2026-07-22T14:42:10.806Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00179114"
    },
    {
      "nct_id": "NCT05432999",
      "title": "Extracorporeal Shockwave Therapy for Spasticity in People With Spinal Cord Injury",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spinal Cord Injuries",
        "Spasticity, Muscle",
        "Spastic Paraplegia",
        "Spastic Quadriplegia",
        "Spastic Tetraplegia",
        "Paraplegia",
        "Tetraplegia"
      ],
      "interventions": [
        {
          "name": "Extracorporeal Shockwave Therapy",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Kessler Foundation",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 5,
      "start_date": "2022-09-01",
      "completion_date": "2025-12-01",
      "has_results": false,
      "last_update_posted_date": "2026-03-25",
      "last_synced_at": "2026-07-22T14:42:10.806Z",
      "location_count": 1,
      "location_summary": "West Orange, New Jersey",
      "locations": [
        {
          "city": "West Orange",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05432999"
    },
    {
      "nct_id": "NCT04217187",
      "title": "Electrical Stimulation After Botulinum Toxin Injections to the Upper Extremity",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Stroke"
      ],
      "interventions": [
        {
          "name": "Neuromuscular Electrical Stimulation",
          "type": "DEVICE"
        },
        {
          "name": "Sham Electrical Stimulation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Texas Woman's University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 28,
      "start_date": "2020-01-13",
      "completion_date": "2021-12-31",
      "has_results": false,
      "last_update_posted_date": "2020-01-07",
      "last_synced_at": "2026-07-22T14:42:10.806Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04217187"
    }
  ]
}