{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Nasolabial+Fold&page=2",
    "query": {
      "condition": "Nasolabial Fold",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Nasolabial+Fold&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-07-24T02:06:53.590Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02607670",
      "title": "Phase 2 Study of TAT4 Gel for Reduction of Nasolabial Folds",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Nasolabial Folds"
      ],
      "interventions": [
        {
          "name": "TAT4 Gel",
          "type": "DRUG"
        },
        {
          "name": "Matching placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Topokine Therapeutics, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "35 Years to 60 Years"
      },
      "enrollment_count": 111,
      "start_date": "2016-01",
      "completion_date": "2016-09",
      "has_results": false,
      "last_update_posted_date": "2016-01-05",
      "last_synced_at": "2026-07-24T02:06:53.590Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02607670"
    },
    {
      "nct_id": "NCT01976663",
      "title": "A Safety and Effectiveness Study of JUVÉDERM VOLIFT® XC Versus Control for Moderate to Severe Nasolabial Folds",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Moderate to Severe Nasolabial Folds"
      ],
      "interventions": [
        {
          "name": "JUVEDERM VOLIFT® XC",
          "type": "DEVICE"
        },
        {
          "name": "Control",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Allergan",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 126,
      "start_date": "2013-10-29",
      "completion_date": "2015-10-26",
      "has_results": true,
      "last_update_posted_date": "2019-05-10",
      "last_synced_at": "2026-07-24T02:06:53.590Z",
      "location_count": 7,
      "location_summary": "Birmingham, Alabama • Los Angeles, California • San Francisco, California + 3 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Coral Gables",
          "state": "Florida"
        },
        {
          "city": "Coral Gables",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01976663"
    },
    {
      "nct_id": "NCT02991040",
      "title": "Study to Evaluate Safety and Efficacy of Revanesse® Ultra + vs Revanesse® Ultra for Correction of NLF",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nasolabial Fold Correction"
      ],
      "interventions": [
        {
          "name": "Revanesse Ultra+ (with lidocaine)",
          "type": "DEVICE"
        },
        {
          "name": "Revanesse Ultra",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Prollenium Medical Technologies Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "22 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2016-08",
      "completion_date": "2017-08",
      "has_results": true,
      "last_update_posted_date": "2019-04-11",
      "last_synced_at": "2026-07-24T02:06:53.590Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02991040"
    },
    {
      "nct_id": "NCT04534660",
      "title": "Preliminary Safety and Effectiveness of SMI-01 as a Tissue Filler",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nasolabial Fold",
        "Cheek Augmentation"
      ],
      "interventions": [
        {
          "name": "SMI-01",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Sofregen Medical, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "22 Years to 65 Years"
      },
      "enrollment_count": 21,
      "start_date": "2020-11-10",
      "completion_date": "2023-06-23",
      "has_results": false,
      "last_update_posted_date": "2024-05-31",
      "last_synced_at": "2026-07-24T02:06:53.590Z",
      "location_count": 2,
      "location_summary": "Encinitas, California • Miami, Florida",
      "locations": [
        {
          "city": "Encinitas",
          "state": "California"
        },
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04534660"
    },
    {
      "nct_id": "NCT02253147",
      "title": "TEOSYAL® RHA Ultra Deep and Perlane-L® for the Correction of Nasolabial Folds",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nasolabial Folds, Wrinkles"
      ],
      "interventions": [
        {
          "name": "TEOSYAL® RHA Ultra Deep",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Teoxane SA",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "22 Years and older"
      },
      "enrollment_count": 140,
      "start_date": "2014-09",
      "completion_date": "2016-05",
      "has_results": true,
      "last_update_posted_date": "2018-03-27",
      "last_synced_at": "2026-07-24T02:06:53.590Z",
      "location_count": 4,
      "location_summary": "Beverly Hills, California • Bradenton, Florida • Chapel Hill, North Carolina + 1 more",
      "locations": [
        {
          "city": "Beverly Hills",
          "state": "California"
        },
        {
          "city": "Bradenton",
          "state": "Florida"
        },
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02253147"
    },
    {
      "nct_id": "NCT01012661",
      "title": "Evaluation of Pain With Lidocaine-Mixed Radiesse® Injectable Dermal Filler",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Nasolabial Folds"
      ],
      "interventions": [
        {
          "name": "Radiesse® Injectable Dermal Filler Mixed with Lidocaine",
          "type": "DEVICE"
        },
        {
          "name": "Radiesse® Injectable Dermal Filler without Lidocaine",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Merz North America, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2008-09",
      "completion_date": "2009-01",
      "has_results": true,
      "last_update_posted_date": "2013-04-26",
      "last_synced_at": "2026-07-24T02:06:53.590Z",
      "location_count": 2,
      "location_summary": "Rockville, Maryland • New York, New York",
      "locations": [
        {
          "city": "Rockville",
          "state": "Maryland"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01012661"
    },
    {
      "nct_id": "NCT06351293",
      "title": "A Comparative Analysis of Two Hyaluronic Acid Fillers for Nasolabial Fold Correction",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkle"
      ],
      "interventions": [
        {
          "name": "Defyne Treatment in Nasolabial Fold",
          "type": "DEVICE"
        },
        {
          "name": "RHA3 Treatment in Nasolabial Fold",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Galderma R&D",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "22 Years to 65 Years"
      },
      "enrollment_count": 15,
      "start_date": "2024-02-21",
      "completion_date": "2025-04-30",
      "has_results": false,
      "last_update_posted_date": "2026-01-16",
      "last_synced_at": "2026-07-24T02:06:53.590Z",
      "location_count": 1,
      "location_summary": "Santa Rosa Beach, Florida",
      "locations": [
        {
          "city": "Santa Rosa Beach",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06351293"
    },
    {
      "nct_id": "NCT00414544",
      "title": "Evaluation of the Safety and Efficacy of CosmetaLife™ for the Correction of Nasolabial Folds",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Facial Wrinkles"
      ],
      "interventions": [
        {
          "name": "CosmetaLife",
          "type": "DEVICE"
        },
        {
          "name": "Restylane",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Cosmeta",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 145,
      "start_date": "2006-10",
      "completion_date": "2008-03",
      "has_results": true,
      "last_update_posted_date": "2011-06-27",
      "last_synced_at": "2026-07-24T02:06:53.590Z",
      "location_count": 5,
      "location_summary": "Tracy, California • Roswell, Georgia • Chestnut Hill, Massachusetts + 2 more",
      "locations": [
        {
          "city": "Tracy",
          "state": "California"
        },
        {
          "city": "Roswell",
          "state": "Georgia"
        },
        {
          "city": "Chestnut Hill",
          "state": "Massachusetts"
        },
        {
          "city": "Edina",
          "state": "Minnesota"
        },
        {
          "city": "Fridley",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00414544"
    },
    {
      "nct_id": "NCT00874094",
      "title": "Pilot Evaluation of Platelet Rich Fibrin Matrix (PRFM) for the Correction of Nasolabial Folds",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Nasolabial Folds"
      ],
      "interventions": [
        {
          "name": "Platelet rich fibrin matrix",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "The New York Eye & Ear Infirmary",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "75 Years",
        "sex": "FEMALE",
        "summary": "25 Years to 75 Years · Female only"
      },
      "enrollment_count": 15,
      "start_date": "2008-04",
      "completion_date": "2009-07",
      "has_results": true,
      "last_update_posted_date": "2013-07-12",
      "last_synced_at": "2026-07-24T02:06:53.590Z",
      "location_count": 1,
      "location_summary": "Chappaqua, New York",
      "locations": [
        {
          "city": "Chappaqua",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00874094"
    },
    {
      "nct_id": "NCT00876265",
      "title": "Multicenter Study of the Safety and Effectiveness of Dermal Filler, Belotero®.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Facial Wrinkles"
      ],
      "interventions": [
        {
          "name": "Belotero",
          "type": "DEVICE"
        },
        {
          "name": "Zyplast",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Merz North America, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 118,
      "start_date": "2006-12",
      "completion_date": "2008-12",
      "has_results": true,
      "last_update_posted_date": "2013-04-26",
      "last_synced_at": "2026-07-24T02:06:53.590Z",
      "location_count": 6,
      "location_summary": "Birmingham, Alabama • Los Angeles, California • San Francisco, California + 3 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Metairie",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00876265"
    }
  ]
}