{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Nasolabial+Folds",
    "query": {
      "condition": "Nasolabial Folds"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 46,
    "total_pages": 5,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Nasolabial+Folds&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T09:45:53.152Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04128046",
      "title": "The Effect of Platelet-rich Fibrin Matrix on Skin Rejuvenation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Skin Rejuvenation",
        "Skin Quality",
        "Wrinkle",
        "Nasolabial Fold"
      ],
      "interventions": [
        {
          "name": "PRFM injection",
          "type": "PROCEDURE"
        },
        {
          "name": "Saline injection",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "New York Medical College",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2018-09-03",
      "completion_date": "2019-06-01",
      "has_results": false,
      "last_update_posted_date": "2019-10-22",
      "last_synced_at": "2026-05-22T09:45:53.152Z",
      "location_count": 1,
      "location_summary": "Valhalla, New York",
      "locations": [
        {
          "city": "Valhalla",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04128046"
    },
    {
      "nct_id": "NCT01012661",
      "title": "Evaluation of Pain With Lidocaine-Mixed Radiesse® Injectable Dermal Filler",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Nasolabial Folds"
      ],
      "interventions": [
        {
          "name": "Radiesse® Injectable Dermal Filler Mixed with Lidocaine",
          "type": "DEVICE"
        },
        {
          "name": "Radiesse® Injectable Dermal Filler without Lidocaine",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Merz North America, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2008-09",
      "completion_date": "2009-01",
      "has_results": true,
      "last_update_posted_date": "2013-04-26",
      "last_synced_at": "2026-05-22T09:45:53.152Z",
      "location_count": 2,
      "location_summary": "Rockville, Maryland • New York, New York",
      "locations": [
        {
          "city": "Rockville",
          "state": "Maryland"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01012661"
    },
    {
      "nct_id": "NCT02647853",
      "title": "Phase 1 Study to Assess the Safety and Tolerability of TAT4 Gel in Healthy Volunteers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Nasolabial Folds",
        "Lipoatrophy",
        "Lipodystrophy"
      ],
      "interventions": [
        {
          "name": "TAT4 Gel concentration A",
          "type": "DRUG"
        },
        {
          "name": "TAT4 Gel concentration B",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Topokine Therapeutics, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "40 Years to 70 Years"
      },
      "enrollment_count": 16,
      "start_date": "2014-10",
      "completion_date": "2014-12",
      "has_results": false,
      "last_update_posted_date": "2016-01-06",
      "last_synced_at": "2026-05-22T09:45:53.152Z",
      "location_count": 1,
      "location_summary": "Cypress, California",
      "locations": [
        {
          "city": "Cypress",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02647853"
    },
    {
      "nct_id": "NCT00797459",
      "title": "Safety & Tolerability Study That Compares Restylane to Restylane With Lidocaine While Correcting Wrinkles in the Nasolabial Folds",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nasolabial Folds"
      ],
      "interventions": [
        {
          "name": "Restylane and Restylane-L",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medicis Global Service Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 60,
      "start_date": "2008-11",
      "completion_date": "2009-03",
      "has_results": true,
      "last_update_posted_date": "2013-09-06",
      "last_synced_at": "2026-05-22T09:45:53.152Z",
      "location_count": 3,
      "location_summary": "Coral Gables, Florida • Hunt Valley, Maryland • Mount Kisco, New York",
      "locations": [
        {
          "city": "Coral Gables",
          "state": "Florida"
        },
        {
          "city": "Hunt Valley",
          "state": "Maryland"
        },
        {
          "city": "Mount Kisco",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00797459"
    },
    {
      "nct_id": "NCT02176356",
      "title": "Patient Satisfaction Study of Combined Facial Treatment With BOTOX® Cosmetic, JUVÉDERM® and LATISSE® (HARMONY Study)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Facial Rhytides",
        "Crow's Feet Lines",
        "Glabellar Lines",
        "Nasolabial Fold"
      ],
      "interventions": [
        {
          "name": "onabotulinumtoxinA",
          "type": "BIOLOGICAL"
        },
        {
          "name": "bimatoprost ophthalmic solution 0.03%",
          "type": "DRUG"
        },
        {
          "name": "JUVÉDERM® ULTRA XC",
          "type": "DEVICE"
        },
        {
          "name": "JUVÉDERM® ULTRA PLUS XC",
          "type": "DEVICE"
        },
        {
          "name": "JUVÉDERM® VOLUMA® XC",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Allergan",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "35 Years to 65 Years"
      },
      "enrollment_count": 116,
      "start_date": "2014-06-30",
      "completion_date": "2015-05-03",
      "has_results": true,
      "last_update_posted_date": "2019-01-09",
      "last_synced_at": "2026-05-22T09:45:53.152Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02176356"
    },
    {
      "nct_id": "NCT04087395",
      "title": "RHA® 4 With New Anesthetic - Nasolabial Folds",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aging",
        "Pain"
      ],
      "interventions": [
        {
          "name": "RHA®4 with new anesthetic agent",
          "type": "DEVICE"
        },
        {
          "name": "RHA®4-Lidocaine",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Teoxane SA",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "22 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2019-10-30",
      "completion_date": "2020-11-09",
      "has_results": true,
      "last_update_posted_date": "2022-01-24",
      "last_synced_at": "2026-05-22T09:45:53.152Z",
      "location_count": 3,
      "location_summary": "Beverly Hills, California • Coral Gables, Florida • Chicago, Illinois",
      "locations": [
        {
          "city": "Beverly Hills",
          "state": "California"
        },
        {
          "city": "Coral Gables",
          "state": "Florida"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04087395"
    },
    {
      "nct_id": "NCT00655356",
      "title": "Safety and Efficacy Study of Isolagen Therapy in the Treatment of Nasolabial Fold Wrinkles",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Bilateral Nasolabial Fold Wrinkles"
      ],
      "interventions": [
        {
          "name": "Autologous Human Fibroblasts (azficel-T)",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Placebo",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Castle Creek Biosciences, LLC.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 218,
      "start_date": "2006-11",
      "completion_date": "2009-05",
      "has_results": true,
      "last_update_posted_date": "2012-03-13",
      "last_synced_at": "2026-05-22T09:45:53.152Z",
      "location_count": 6,
      "location_summary": "Beverly Hills, California • San Diego, California • Snellville, Georgia + 3 more",
      "locations": [
        {
          "city": "Beverly Hills",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Snellville",
          "state": "Georgia"
        },
        {
          "city": "San Antonio",
          "state": "Texas"
        },
        {
          "city": "Charlottesville",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00655356"
    },
    {
      "nct_id": "NCT00764257",
      "title": "PREVELLE Shape (CX002) Dermal Filler Protocol",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Correction of Nasolabial Folds and Lip Augmentation"
      ],
      "interventions": [
        {
          "name": "PREVELLE Shape",
          "type": "DEVICE"
        },
        {
          "name": "Restylane",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Mentor Worldwide, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": null,
      "start_date": "2004-10",
      "completion_date": "2007-01",
      "has_results": false,
      "last_update_posted_date": "2011-12-20",
      "last_synced_at": "2026-05-22T09:45:53.152Z",
      "location_count": 1,
      "location_summary": "Santa Barbara, California",
      "locations": [
        {
          "city": "Santa Barbara",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00764257"
    },
    {
      "nct_id": "NCT02425943",
      "title": "Sculptra Aesthetic Post-Approval Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Nasolabial Fold Contour Deficiencies",
        "Wrinkles"
      ],
      "interventions": [
        {
          "name": "injectable poly-L-lactic acid Sculptra Aesthetic",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Galderma R&D",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 867,
      "start_date": "2015-05-21",
      "completion_date": "2021-05-28",
      "has_results": true,
      "last_update_posted_date": "2023-07-27",
      "last_synced_at": "2026-05-22T09:45:53.152Z",
      "location_count": 18,
      "location_summary": "Birmingham, Alabama • Encino, California • Hermosa Beach, California + 15 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Encino",
          "state": "California"
        },
        {
          "city": "Hermosa Beach",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Solana Beach",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02425943"
    },
    {
      "nct_id": "NCT00765583",
      "title": "A Study to Determine How Long Restylane® Will Last After Initial Treatment With 2 Different Re-treatment Schedules.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Rhytids"
      ],
      "interventions": [
        {
          "name": "Restylane",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Medicis Aesthetics, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 75,
      "start_date": "2005-11",
      "completion_date": "2009-02",
      "has_results": false,
      "last_update_posted_date": "2011-09-22",
      "last_synced_at": "2026-05-22T09:45:53.152Z",
      "location_count": 3,
      "location_summary": "Coral Gables, Florida • Chicago, Illinois • White Plains, New York",
      "locations": [
        {
          "city": "Coral Gables",
          "state": "Florida"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "White Plains",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00765583"
    }
  ]
}