{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Nasolabial+Folds%2C+Wrinkles&page=2",
    "query": {
      "condition": "Nasolabial Folds, Wrinkles",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Nasolabial+Folds%2C+Wrinkles&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-07-23T19:11:17.528Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00414544",
      "title": "Evaluation of the Safety and Efficacy of CosmetaLife™ for the Correction of Nasolabial Folds",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Facial Wrinkles"
      ],
      "interventions": [
        {
          "name": "CosmetaLife",
          "type": "DEVICE"
        },
        {
          "name": "Restylane",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Cosmeta",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 145,
      "start_date": "2006-10",
      "completion_date": "2008-03",
      "has_results": true,
      "last_update_posted_date": "2011-06-27",
      "last_synced_at": "2026-07-23T19:11:17.528Z",
      "location_count": 5,
      "location_summary": "Tracy, California • Roswell, Georgia • Chestnut Hill, Massachusetts + 2 more",
      "locations": [
        {
          "city": "Tracy",
          "state": "California"
        },
        {
          "city": "Roswell",
          "state": "Georgia"
        },
        {
          "city": "Chestnut Hill",
          "state": "Massachusetts"
        },
        {
          "city": "Edina",
          "state": "Minnesota"
        },
        {
          "city": "Fridley",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00414544"
    },
    {
      "nct_id": "NCT00876265",
      "title": "Multicenter Study of the Safety and Effectiveness of Dermal Filler, Belotero®.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Facial Wrinkles"
      ],
      "interventions": [
        {
          "name": "Belotero",
          "type": "DEVICE"
        },
        {
          "name": "Zyplast",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Merz North America, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 118,
      "start_date": "2006-12",
      "completion_date": "2008-12",
      "has_results": true,
      "last_update_posted_date": "2013-04-26",
      "last_synced_at": "2026-07-23T19:11:17.528Z",
      "location_count": 6,
      "location_summary": "Birmingham, Alabama • Los Angeles, California • San Francisco, California + 3 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Metairie",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00876265"
    },
    {
      "nct_id": "NCT00293163",
      "title": "A Post-Market Study to Evaluate Adverse Event Incidence Rates in Patients With Skin of Color Undergoing Correction of Nasolabial Folds With Hylaform, Hylaform Plus and Captique.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Facial Wrinkles"
      ],
      "interventions": [
        {
          "name": "Hylaform, Hylaform Plus (hylan B gel)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Genzyme, a Sanofi Company",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 120,
      "start_date": "2006-02",
      "completion_date": "2006-10",
      "has_results": false,
      "last_update_posted_date": "2015-03-05",
      "last_synced_at": "2026-07-23T19:11:17.528Z",
      "location_count": 3,
      "location_summary": "Los Angeles, California • Warren, Michigan • Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Warren",
          "state": "Michigan"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00293163"
    },
    {
      "nct_id": "NCT00444210",
      "title": "DL6049 vs CosmoPlast in the Treatment of Nasolabial Fold Wrinkles",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Nasolabial Fold Wrinkles"
      ],
      "interventions": [
        {
          "name": "DL6049 (injectable poly-L-lactic acid)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Bausch Health Americas, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 240,
      "start_date": "2004-06",
      "completion_date": "2006-04",
      "has_results": false,
      "last_update_posted_date": "2019-09-18",
      "last_synced_at": "2026-07-23T19:11:17.528Z",
      "location_count": 1,
      "location_summary": "Bridgewater, New Jersey",
      "locations": [
        {
          "city": "Bridgewater",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00444210"
    },
    {
      "nct_id": "NCT00649428",
      "title": "Safety and Efficacy Study of Isolagen TherapyTM in the Treatment of Nasolabial Fold Wrinkles",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Bilateral Nasolabial Fold Wrinkles"
      ],
      "interventions": [
        {
          "name": "Autologous Human Fibroblast (azficel-T)",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Placebo",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Castle Creek Biosciences, LLC.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 203,
      "start_date": "2006-10",
      "completion_date": "2009-05",
      "has_results": true,
      "last_update_posted_date": "2012-03-13",
      "last_synced_at": "2026-07-23T19:11:17.528Z",
      "location_count": 7,
      "location_summary": "Birmingham, Alabama • Newport Beach, California • Coral Gables, Florida + 4 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Newport Beach",
          "state": "California"
        },
        {
          "city": "Coral Gables",
          "state": "Florida"
        },
        {
          "city": "Naperville",
          "state": "Illinois"
        },
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00649428"
    },
    {
      "nct_id": "NCT00797459",
      "title": "Safety & Tolerability Study That Compares Restylane to Restylane With Lidocaine While Correcting Wrinkles in the Nasolabial Folds",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nasolabial Folds"
      ],
      "interventions": [
        {
          "name": "Restylane and Restylane-L",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medicis Global Service Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 60,
      "start_date": "2008-11",
      "completion_date": "2009-03",
      "has_results": true,
      "last_update_posted_date": "2013-09-06",
      "last_synced_at": "2026-07-23T19:11:17.528Z",
      "location_count": 3,
      "location_summary": "Coral Gables, Florida • Hunt Valley, Maryland • Mount Kisco, New York",
      "locations": [
        {
          "city": "Coral Gables",
          "state": "Florida"
        },
        {
          "city": "Hunt Valley",
          "state": "Maryland"
        },
        {
          "city": "Mount Kisco",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00797459"
    },
    {
      "nct_id": "NCT00877279",
      "title": "Multicenter Study of the Safety and Efficacy of Dermal Filler, Belotero® Soft",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Facial Wrinkles"
      ],
      "interventions": [
        {
          "name": "CosmoDerm1",
          "type": "DEVICE"
        },
        {
          "name": "Belotero Soft",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Merz North America, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 64,
      "start_date": "2007-11",
      "completion_date": "2008-03",
      "has_results": false,
      "last_update_posted_date": "2013-11-15",
      "last_synced_at": "2026-07-23T19:11:17.528Z",
      "location_count": 5,
      "location_summary": "Los Angeles, California • San Francisco, California • New Haven, Connecticut + 2 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Metairie",
          "state": "Louisiana"
        },
        {
          "city": "White Plains",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00877279"
    },
    {
      "nct_id": "NCT04957446",
      "title": "Histology Study of Biostimulatory Activity of Injectable Poly-L-Lactic Acid (Sculptra Aesthetic)",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nasolabial Fold",
        "Facial Wrinkles"
      ],
      "interventions": [
        {
          "name": "Sculptra Aesthetic",
          "type": "DEVICE"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Sadick Research Group",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "30 Years to 65 Years"
      },
      "enrollment_count": 10,
      "start_date": "2021-08-09",
      "completion_date": "2022-09-01",
      "has_results": false,
      "last_update_posted_date": "2021-08-11",
      "last_synced_at": "2026-07-23T19:11:17.528Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04957446"
    },
    {
      "nct_id": "NCT00922623",
      "title": "Safety and Effectiveness of Belotero® in Subjects With Fitzpatrick Phototypes IV Through VI",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Facial Wrinkles"
      ],
      "interventions": [
        {
          "name": "Belotero®",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Merz North America, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 93,
      "start_date": "2009-05",
      "completion_date": "2010-07",
      "has_results": true,
      "last_update_posted_date": "2013-04-26",
      "last_synced_at": "2026-07-23T19:11:17.528Z",
      "location_count": 3,
      "location_summary": "Los Angeles, California • Mitchellville, Maryland • Montclair, New Jersey",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Mitchellville",
          "state": "Maryland"
        },
        {
          "city": "Montclair",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00922623"
    },
    {
      "nct_id": "NCT02425943",
      "title": "Sculptra Aesthetic Post-Approval Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Nasolabial Fold Contour Deficiencies",
        "Wrinkles"
      ],
      "interventions": [
        {
          "name": "injectable poly-L-lactic acid Sculptra Aesthetic",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Galderma R&D",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 867,
      "start_date": "2015-05-21",
      "completion_date": "2021-05-28",
      "has_results": true,
      "last_update_posted_date": "2023-07-27",
      "last_synced_at": "2026-07-23T19:11:17.528Z",
      "location_count": 18,
      "location_summary": "Birmingham, Alabama • Encino, California • Hermosa Beach, California + 15 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Encino",
          "state": "California"
        },
        {
          "city": "Hermosa Beach",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Solana Beach",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02425943"
    }
  ]
}