{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Neonatal+Opioid+Withdrawal",
    "query": {
      "condition": "Neonatal Opioid Withdrawal"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 25,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Neonatal+Opioid+Withdrawal&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T02:50:24.313Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05937594",
      "title": "MicroRNA Biomarkers for Neonatal Opioid Withdrawal Syndrome",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Neonatal Opioid Withdrawal Syndrome",
        "Neonatal Abstinence Syndrome"
      ],
      "interventions": [
        {
          "name": "Buccal swab saliva for further genetic testing",
          "type": "GENETIC"
        }
      ],
      "intervention_types": [
        "GENETIC"
      ],
      "sponsor": "Milton S. Hershey Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Day",
        "maximum_age": "5 Days",
        "sex": "ALL",
        "summary": "1 Day to 5 Days"
      },
      "enrollment_count": 50,
      "start_date": "2020-01-15",
      "completion_date": "2027-04-10",
      "has_results": false,
      "last_update_posted_date": "2026-02-10",
      "last_synced_at": "2026-05-22T02:50:24.313Z",
      "location_count": 1,
      "location_summary": "Hershey, Pennsylvania",
      "locations": [
        {
          "city": "Hershey",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05937594"
    },
    {
      "nct_id": "NCT04214834",
      "title": "Trial to Shorten Pharmacologic Treatment of Newborns With Neonatal Opioid Withdrawal Syndrome (NOWS)",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Neonatal Opioid Withdrawal Syndrome"
      ],
      "interventions": [
        {
          "name": "Morphine",
          "type": "DRUG"
        },
        {
          "name": "Methadone",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Advancing Clinical Trials in Neonatal Opioid Withdrawal (ACT NOW) Program",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "36 Weeks",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "36 Weeks and older"
      },
      "enrollment_count": 189,
      "start_date": "2020-09-28",
      "completion_date": "2026-06-30",
      "has_results": true,
      "last_update_posted_date": "2025-03-13",
      "last_synced_at": "2026-05-22T02:50:24.313Z",
      "location_count": 24,
      "location_summary": "Birmingham, Alabama • Tucson, Arizona • Little Rock, Arkansas + 18 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Loma Linda",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04214834"
    },
    {
      "nct_id": "NCT07278375",
      "title": "Target Trial Emulation for Pharmacologic Treatment of Neonatal Opioid Withdrawal Syndrome",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Neonatal Opioid Withdrawal Syndrome"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "HELP for NOWS Consortium",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "0 Minutes",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "0 Minutes and older"
      },
      "enrollment_count": 796,
      "start_date": "2025-12-09",
      "completion_date": "2026-08-30",
      "has_results": false,
      "last_update_posted_date": "2026-02-25",
      "last_synced_at": "2026-05-22T02:50:24.313Z",
      "location_count": 22,
      "location_summary": "Birmingham, Alabama • Little Rock, Arkansas • Wilmington, Delaware + 14 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Wilmington",
          "state": "Delaware"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07278375"
    },
    {
      "nct_id": "NCT05980260",
      "title": "Optimizing Pharmacologic Treatment for Neonatal Opioid Withdrawal Syndrome (OPTimize NOW): A Symptom-Based Dosing Approach",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Neonatal Opiate Withdrawal Syndrome"
      ],
      "interventions": [
        {
          "name": "Symptom-based Dosing Approach",
          "type": "OTHER"
        },
        {
          "name": "Scheduled Opioid Taper Approach",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "HELP for NOWS Consortium",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Hour",
        "maximum_age": "48 Hours",
        "sex": "ALL",
        "summary": "1 Hour to 48 Hours"
      },
      "enrollment_count": 626,
      "start_date": "2024-03-25",
      "completion_date": "2025-07-15",
      "has_results": false,
      "last_update_posted_date": "2026-05-18",
      "last_synced_at": "2026-05-22T02:50:24.313Z",
      "location_count": 23,
      "location_summary": "Birmingham, Alabama • Little Rock, Arkansas • Wilmington, Delaware + 16 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Wilmington",
          "state": "Delaware"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05980260"
    },
    {
      "nct_id": "NCT01360450",
      "title": "Clonidine to Treat Iatrogenic-induced Opioid Dependence in Infants",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Neonatal Abstinence Syndrome"
      ],
      "interventions": [
        {
          "name": "Clonidine HCL",
          "type": "DRUG"
        },
        {
          "name": "saline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "5 Days",
        "maximum_age": "90 Days",
        "sex": "ALL",
        "summary": "5 Days to 90 Days"
      },
      "enrollment_count": 12,
      "start_date": "2011-07",
      "completion_date": "2014-12",
      "has_results": true,
      "last_update_posted_date": "2017-09-13",
      "last_synced_at": "2026-05-22T02:50:24.313Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01360450"
    },
    {
      "nct_id": "NCT03987165",
      "title": "The Effect of Music Therapy on Newborns",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Neonatal Abstinence Syndrome",
        "Substance Withdrawal, Neonatal"
      ],
      "interventions": [
        {
          "name": "Music Therapy",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Tulane University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "1 Minute",
        "maximum_age": "1 Month",
        "sex": "ALL",
        "summary": "1 Minute to 1 Month"
      },
      "enrollment_count": 42,
      "start_date": "2018-12-10",
      "completion_date": "2024-08-07",
      "has_results": false,
      "last_update_posted_date": "2024-08-09",
      "last_synced_at": "2026-05-22T02:50:24.313Z",
      "location_count": 1,
      "location_summary": "Metairie, Louisiana",
      "locations": [
        {
          "city": "Metairie",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03987165"
    },
    {
      "nct_id": "NCT04049799",
      "title": "Maternal Opioid Treatment: Human Experimental Research - Data Yield Appropriate Decisions",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Opioid-use Disorder",
        "Opioid Withdrawal",
        "Neonatal Abstinence Syndrome",
        "Neonatal Opioid Withdrawal Syndrome"
      ],
      "interventions": [
        {
          "name": "Medically-supervised withdrawal",
          "type": "OTHER"
        },
        {
          "name": "Opioid agonist treatment",
          "type": "OTHER"
        },
        {
          "name": "Comprehensive clinical care",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "OTHER",
        "BEHAVIORAL"
      ],
      "sponsor": "University of Vermont",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "41 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 41 Years · Female only"
      },
      "enrollment_count": 88,
      "start_date": "2019-08-08",
      "completion_date": "2024-02-01",
      "has_results": false,
      "last_update_posted_date": "2024-02-08",
      "last_synced_at": "2026-05-22T02:50:24.313Z",
      "location_count": 4,
      "location_summary": "Asheville, North Carolina • Chapel Hill, North Carolina • Burlington, Vermont + 1 more",
      "locations": [
        {
          "city": "Asheville",
          "state": "North Carolina"
        },
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        },
        {
          "city": "Burlington",
          "state": "Vermont"
        },
        {
          "city": "Richmond",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04049799"
    },
    {
      "nct_id": "NCT05129020",
      "title": "Neurostimulation to Improve NOWS Outcomes",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Neonatal Opioid Withdrawal Syndrome",
        "Neonatal Abstinence Syndrome"
      ],
      "interventions": [
        {
          "name": "Sparrow Fledging Therapy System",
          "type": "DEVICE"
        },
        {
          "name": "Sham Sparrow Fledging Therapy System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Spark Biomedical, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "33 Weeks",
        "maximum_age": "1 Year",
        "sex": "ALL",
        "summary": "33 Weeks to 1 Year"
      },
      "enrollment_count": 52,
      "start_date": "2022-07-27",
      "completion_date": "2027-01-31",
      "has_results": false,
      "last_update_posted_date": "2026-04-13",
      "last_synced_at": "2026-05-22T02:50:24.313Z",
      "location_count": 3,
      "location_summary": "Charleston, South Carolina • Dallas, Texas • San Antonio, Texas",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        },
        {
          "city": "Dallas",
          "state": "Texas"
        },
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05129020"
    },
    {
      "nct_id": "NCT00510016",
      "title": "Clonidine as Adjunct Therapy for the Treatment of Neonatal Abstinence Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Neonatal Abstinence Syndrome"
      ],
      "interventions": [
        {
          "name": "Clonidine HCL",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Institute on Drug Abuse (NIDA)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "14 Days",
        "sex": "ALL",
        "summary": "Up to 14 Days"
      },
      "enrollment_count": 80,
      "start_date": "2002-07",
      "completion_date": "2005-12",
      "has_results": false,
      "last_update_posted_date": "2017-01-11",
      "last_synced_at": "2026-05-22T02:50:24.313Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00510016"
    },
    {
      "nct_id": "NCT03911466",
      "title": "Medication Treatment for Opioid Use Disorder in Expectant Mothers: Conceptual Model Assessments Sub-study",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Opioid-Related Disorders",
        "Drug Addiction",
        "Pregnancy Related",
        "Substance Abuse",
        "Drug Abuse",
        "Neonatal Abstinence Syndrome",
        "Neonatal Opioid Withdrawal Syndrome",
        "Drug Abuse in Pregnancy"
      ],
      "interventions": [
        {
          "name": "Buprenorphine Injection",
          "type": "DRUG"
        },
        {
          "name": "Buprenorphine Sublingual Product",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "T. John Winhusen, PhD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "41 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 41 Years · Female only"
      },
      "enrollment_count": 97,
      "start_date": "2020-07-21",
      "completion_date": "2024-11-06",
      "has_results": false,
      "last_update_posted_date": "2026-03-16",
      "last_synced_at": "2026-05-22T02:50:24.313Z",
      "location_count": 12,
      "location_summary": "Jacksonville, Florida • Boston, Massachusetts • Albuquerque, New Mexico + 8 more",
      "locations": [
        {
          "city": "Jacksonville",
          "state": "Florida"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Albuquerque",
          "state": "New Mexico"
        },
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03911466"
    }
  ]
}