{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Neural+Tube+Defects+%28NTDs%29",
    "query": {
      "condition": "Neural Tube Defects (NTDs)"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 95,
    "total_pages": 10,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Neural+Tube+Defects+%28NTDs%29&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T20:17:32.367Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05639686",
      "title": "TIVA vs TXA in Sinus Surgery to Evaluate Operative Blood Loss and Surgical Field Quality",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Rhinosinusitis Chronic",
        "Sinus Cancer",
        "Sinus Polyp",
        "Encephalocele"
      ],
      "interventions": [
        {
          "name": "Tranexamic acid injection",
          "type": "DRUG"
        },
        {
          "name": "Total Intravenous Anesthesia",
          "type": "DRUG"
        },
        {
          "name": "Inhalational isoflurane",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Our Lady of the Lake Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2023-01-01",
      "completion_date": "2025-07-01",
      "has_results": false,
      "last_update_posted_date": "2023-03-23",
      "last_synced_at": "2026-07-22T20:17:32.367Z",
      "location_count": 1,
      "location_summary": "Baton Rouge, Louisiana",
      "locations": [
        {
          "city": "Baton Rouge",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05639686"
    },
    {
      "nct_id": "NCT04484441",
      "title": "Maternal-fetal Immune Responses to Fetal Surgery",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Spina Bifida",
        "Congenital Diaphragmatic Hernia",
        "Lower Urinary Tract Obstructive Syndrome",
        "Myelomeningocele"
      ],
      "interventions": [
        {
          "name": "Blood and placenta specimen collection.",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 50 Years · Female only"
      },
      "enrollment_count": 21,
      "start_date": "2022-03-24",
      "completion_date": "2025-12-01",
      "has_results": false,
      "last_update_posted_date": "2026-02-10",
      "last_synced_at": "2026-07-22T20:17:32.367Z",
      "location_count": 3,
      "location_summary": "Rochester, Minnesota • Cincinnati, Ohio • Houston, Texas",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        },
        {
          "city": "Cincinnati",
          "state": "Ohio"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04484441"
    },
    {
      "nct_id": "NCT02493062",
      "title": "Evaluation of Hysterotomy Site After Open Fetal Surgery",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Myelomeningocele",
        "Pregnancy"
      ],
      "interventions": [
        {
          "name": "Sonohysterogram",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "St. Louis University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 50 Years · Female only"
      },
      "enrollment_count": 35,
      "start_date": "2013-06",
      "completion_date": "2017-12-20",
      "has_results": true,
      "last_update_posted_date": "2019-02-05",
      "last_synced_at": "2026-07-22T20:17:32.367Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02493062"
    },
    {
      "nct_id": "NCT00891891",
      "title": "Psychosocial Adjustment of Adolescents With Spina Bifida",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Spina Bifida"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Loyola University Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": "15 Years",
        "sex": "ALL",
        "summary": "8 Years to 15 Years"
      },
      "enrollment_count": 140,
      "start_date": "2005-09",
      "completion_date": "2025-08-01",
      "has_results": false,
      "last_update_posted_date": "2025-04-18",
      "last_synced_at": "2026-07-22T20:17:32.367Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00891891"
    },
    {
      "nct_id": "NCT03797378",
      "title": "Movement-2-Music: Lakeshore Examination of Activity, Disability, and Exercise Response Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spinal Cord Injuries",
        "Traumatic Brain Injury",
        "Spina Bifida",
        "Cerebral Palsy",
        "Stroke",
        "Parkinson Disease",
        "Multiple Sclerosis"
      ],
      "interventions": [
        {
          "name": "eM2M",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 108,
      "start_date": "2019-08-09",
      "completion_date": "2025-09-29",
      "has_results": false,
      "last_update_posted_date": "2025-10-03",
      "last_synced_at": "2026-07-22T20:17:32.367Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03797378"
    },
    {
      "nct_id": "NCT02341950",
      "title": "Clinical Trial of a Serious Game for Individuals With SCI/D",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spinal Cord Injury",
        "Spinal Cord Involvement",
        "Spina Bifida",
        "Transverse Myelitis",
        "Polio and Post-polio Syndrome",
        "Syringomyelia",
        "Spinal Stenosis",
        "Spinal Neoplasms",
        "Spinal Cord Diseases"
      ],
      "interventions": [
        {
          "name": "SCI Hard",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "13 Years",
        "maximum_age": "29 Years",
        "sex": "ALL",
        "summary": "13 Years to 29 Years"
      },
      "enrollment_count": 184,
      "start_date": "2015-02-05",
      "completion_date": "2017-09-01",
      "has_results": false,
      "last_update_posted_date": "2019-02-22",
      "last_synced_at": "2026-07-22T20:17:32.367Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02341950"
    },
    {
      "nct_id": "NCT07290556",
      "title": "Establishing the Preliminary Utility of a Novel Pediatric Manual Mobile Standing Wheelchair",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spina Bifida"
      ],
      "interventions": [
        {
          "name": "PedMMSWC Wheelchair User Testing",
          "type": "DEVICE"
        },
        {
          "name": "PedMMSWC Simulated Home, School, Community Environment",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Optimal Mobility, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "8 Years to 17 Years"
      },
      "enrollment_count": 30,
      "start_date": "2026-06-18",
      "completion_date": "2027-08-25",
      "has_results": false,
      "last_update_posted_date": "2026-06-24",
      "last_synced_at": "2026-07-22T20:17:32.367Z",
      "location_count": 1,
      "location_summary": "Saint Paul, Minnesota",
      "locations": [
        {
          "city": "Saint Paul",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07290556"
    },
    {
      "nct_id": "NCT01253746",
      "title": "Genetics of Neural Tube Defects",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Neural Tube Defects"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "John P. Hussman Institute for Human Genomics",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 6000,
      "start_date": "2009-04",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2010-12-03",
      "last_synced_at": "2026-07-22T20:17:32.367Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01253746"
    },
    {
      "nct_id": "NCT04243889",
      "title": "Fetoscopic NEOX Cord 1K® Spina Bifida Repair",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spina Bifida",
        "Myelomeningocele",
        "Myeloschisis"
      ],
      "interventions": [
        {
          "name": "NEOX Cord 1K",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2020-08-28",
      "completion_date": "2029-03-12",
      "has_results": false,
      "last_update_posted_date": "2025-09-03",
      "last_synced_at": "2026-07-22T20:17:32.367Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04243889"
    },
    {
      "nct_id": "NCT02938130",
      "title": "The Impact of Community-based Wellness Programs on The Triple Aim",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Spina Bifida",
        "Cerebral Palsy",
        "Spinal Cord Injury",
        "Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "Wellness Programs",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "7 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "7 Years and older"
      },
      "enrollment_count": 130,
      "start_date": "2016-10",
      "completion_date": "2023-08-24",
      "has_results": false,
      "last_update_posted_date": "2025-09-12",
      "last_synced_at": "2026-07-22T20:17:32.367Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02938130"
    }
  ]
}