{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=New+Daily+Persistent+Headache+%28NDPH%29",
    "query": {
      "condition": "New Daily Persistent Headache (NDPH)"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 9,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T06:47:48.153Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01920945",
      "title": "OnabotulinumtoxinA for the Treatment of New Daily Persistent Headache: an Open Label Study",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "New Daily Persistent Headache"
      ],
      "interventions": [
        {
          "name": "OnabotulinumtoxinA",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "St. Luke's-Roosevelt Hospital Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 6,
      "start_date": "2014-09",
      "completion_date": "2016-10",
      "has_results": false,
      "last_update_posted_date": "2016-10-26",
      "last_synced_at": "2026-05-22T06:47:48.153Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01920945"
    },
    {
      "nct_id": "NCT00335803",
      "title": "A Research Study To Compare Two Kinds Of Daily Headache",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Migraine"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Thomas Jefferson University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "14 Years to 65 Years"
      },
      "enrollment_count": null,
      "start_date": "2006-03",
      "completion_date": "2007-09",
      "has_results": false,
      "last_update_posted_date": "2009-01-23",
      "last_synced_at": "2026-05-22T06:47:48.153Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00335803"
    },
    {
      "nct_id": "NCT05536050",
      "title": "Study of Low-dose Naltrexone in Chronic Migraine With Fibromyalgia",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Chronic Migraine",
        "Fibromyalgia",
        "New Daily Persistent Headache"
      ],
      "interventions": [
        {
          "name": "Migraine diary and Questionnaires",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Thomas Jefferson University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2022-07-28",
      "completion_date": "2023-12",
      "has_results": false,
      "last_update_posted_date": "2022-10-27",
      "last_synced_at": "2026-05-22T06:47:48.153Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05536050"
    },
    {
      "nct_id": "NCT05984719",
      "title": "New Daily Persistent Headache Survey",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "New Daily Persistent Headache (NDPH)",
        "New Daily Persistent Headache"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "13 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "13 Years and older"
      },
      "enrollment_count": 803,
      "start_date": "2023-06-19",
      "completion_date": "2024-01-31",
      "has_results": false,
      "last_update_posted_date": "2026-02-18",
      "last_synced_at": "2026-05-22T06:47:48.153Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05984719"
    },
    {
      "nct_id": "NCT03447782",
      "title": "Endogenous Modulation and Central Sensitization in New Daily Persistent Headache ( NDPH ) in Children",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "New Daily Persistent Headache (NDPH)"
      ],
      "interventions": [
        {
          "name": "Naltrexone HCl (Bulk) Powder",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Boston Children's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "10 Years to 17 Years"
      },
      "enrollment_count": 45,
      "start_date": "2018-07-23",
      "completion_date": "2020-11-20",
      "has_results": true,
      "last_update_posted_date": "2022-05-06",
      "last_synced_at": "2026-05-22T06:47:48.153Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03447782"
    },
    {
      "nct_id": "NCT05310227",
      "title": "Nerivio Device for Treatment of New Daily Headache Persistence (NDHP)",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "New Daily Persistent Headache (NDPH)"
      ],
      "interventions": [
        {
          "name": "Nerivio",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Children's National Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "12 Years to 17 Years"
      },
      "enrollment_count": 0,
      "start_date": "2022-02-01",
      "completion_date": "2023-09-11",
      "has_results": false,
      "last_update_posted_date": "2025-07-24",
      "last_synced_at": "2026-05-22T06:47:48.153Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05310227"
    },
    {
      "nct_id": "NCT03231241",
      "title": "Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Chronic Daily Headache",
        "Chronic Migraine"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 700,
      "start_date": "2014-12-12",
      "completion_date": "2026-09-01",
      "has_results": false,
      "last_update_posted_date": "2025-07-23",
      "last_synced_at": "2026-05-22T06:47:48.153Z",
      "location_count": 1,
      "location_summary": "Stanford, California",
      "locations": [
        {
          "city": "Stanford",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03231241"
    },
    {
      "nct_id": "NCT06018025",
      "title": "NDPH Biomarker Study in Children and Adolescents",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "New Persistent Daily Headache"
      ],
      "interventions": [
        {
          "name": "CGRP antibody",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "10 Years to 18 Years"
      },
      "enrollment_count": 38,
      "start_date": "2024-04-15",
      "completion_date": "2025-05-29",
      "has_results": false,
      "last_update_posted_date": "2025-12-01",
      "last_synced_at": "2026-05-22T06:47:48.153Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06018025"
    },
    {
      "nct_id": "NCT04260087",
      "title": "New Daily Persistent Headache Biomarkers Study",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "New Daily Persistent Headache",
        "New Daily Persistent Headache (NDPH)"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Albert Einstein College of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 8,
      "start_date": "2018-05-01",
      "completion_date": "2021-11-18",
      "has_results": false,
      "last_update_posted_date": "2022-03-03",
      "last_synced_at": "2026-05-22T06:47:48.153Z",
      "location_count": 1,
      "location_summary": "The Bronx, New York",
      "locations": [
        {
          "city": "The Bronx",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04260087"
    }
  ]
}