{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Newborn+Hypoxic+Ischemic+Encephalopathy&page=2",
    "query": {
      "condition": "Newborn Hypoxic Ischemic Encephalopathy",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Newborn+Hypoxic+Ischemic+Encephalopathy&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-10T23:26:49.470Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06448780",
      "title": "Dose Optimization of Caffeine for HIE",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Hypoxic-Ischemic Encephalopathy"
      ],
      "interventions": [
        {
          "name": "Caffeine citrate 20 mg/kg",
          "type": "DRUG"
        },
        {
          "name": "Caffeine citrate 30 mg/kg",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "24 Hours",
        "sex": "ALL",
        "summary": "Up to 24 Hours"
      },
      "enrollment_count": 16,
      "start_date": "2024-07-26",
      "completion_date": "2028-11",
      "has_results": false,
      "last_update_posted_date": "2026-04-07",
      "last_synced_at": "2026-06-10T23:26:49.470Z",
      "location_count": 2,
      "location_summary": "Chapel Hill, North Carolina • Wilmington, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        },
        {
          "city": "Wilmington",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06448780"
    },
    {
      "nct_id": "NCT01913340",
      "title": "Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Hypoxic-ischemic Encephalopathy",
        "Neonatal Encephalopathy",
        "Birth Asphyxia"
      ],
      "interventions": [
        {
          "name": "Erythropoietin",
          "type": "DRUG"
        },
        {
          "name": "Normal saline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Minutes",
        "maximum_age": "24 Hours",
        "sex": "ALL",
        "summary": "30 Minutes to 24 Hours"
      },
      "enrollment_count": 50,
      "start_date": "2013-09",
      "completion_date": "2016-09",
      "has_results": true,
      "last_update_posted_date": "2020-07-13",
      "last_synced_at": "2026-06-10T23:26:49.470Z",
      "location_count": 7,
      "location_summary": "Little Rock, Arkansas • Palo Alto, California • San Francisco, California + 4 more",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Santa Clara",
          "state": "California"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01913340"
    },
    {
      "nct_id": "NCT01192776",
      "title": "Optimizing (Longer, Deeper) Cooling for Neonatal Hypoxic-Ischemic Encephalopathy(HIE)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Infant, Newborn",
        "Hypoxia, Brain",
        "Hypoxia-Ischemia, Brain",
        "Encephalopathy, Hypoxic-Ischemic",
        "Hypoxic-Ischemic Encephalopathy",
        "Ischemic-Hypoxic Encephalopathy"
      ],
      "interventions": [
        {
          "name": "Whole-body Cooling",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "NICHD Neonatal Research Network",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "6 Hours",
        "sex": "ALL",
        "summary": "Up to 6 Hours"
      },
      "enrollment_count": 364,
      "start_date": "2010-09",
      "completion_date": "2016-03",
      "has_results": true,
      "last_update_posted_date": "2025-11-28",
      "last_synced_at": "2026-06-10T23:26:49.470Z",
      "location_count": 19,
      "location_summary": "Birmingham, Alabama • Los Angeles, California • Palo Alto, California + 15 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01192776"
    },
    {
      "nct_id": "NCT03635450",
      "title": "Study of hCT-MSC in Newborn Infants With Moderate or Severe HIE",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Moderate to Severe Hypoxic-ischemic Encephalopathy"
      ],
      "interventions": [
        {
          "name": "Infusion of hCT-MSC",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Joanne Kurtzberg, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "0 Hours",
        "maximum_age": "48 Hours",
        "sex": "ALL",
        "summary": "0 Hours to 48 Hours"
      },
      "enrollment_count": 6,
      "start_date": "2018-12-27",
      "completion_date": "2020-12-28",
      "has_results": false,
      "last_update_posted_date": "2024-04-12",
      "last_synced_at": "2026-06-10T23:26:49.470Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03635450"
    },
    {
      "nct_id": "NCT05520359",
      "title": "Spinal Stimulation and Mobility Devices",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cerebral Palsy",
        "Stroke",
        "Premature Birth",
        "Hypoxic-Ischemic Encephalopathy",
        "Periventricular Leukomalacia"
      ],
      "interventions": [
        {
          "name": "Mobility Device",
          "type": "DEVICE"
        },
        {
          "name": "Spinal Stimulation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Washington",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "4 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "4 Years to 70 Years"
      },
      "enrollment_count": 20,
      "start_date": "2022-08-04",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2025-08-13",
      "last_synced_at": "2026-06-10T23:26:49.470Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05520359"
    },
    {
      "nct_id": "NCT00830531",
      "title": "Pilot Study of Bumetanide for Newborn Seizures",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Seizures"
      ],
      "interventions": [
        {
          "name": "Bumetanide",
          "type": "DRUG"
        },
        {
          "name": "Normal Saline as Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Soul, Janet , M.D.",
      "sponsor_class": "INDIV",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "44 Weeks",
        "sex": "ALL",
        "summary": "Up to 44 Weeks"
      },
      "enrollment_count": 43,
      "start_date": "2010-01",
      "completion_date": "2019-01",
      "has_results": false,
      "last_update_posted_date": "2020-12-17",
      "last_synced_at": "2026-06-10T23:26:49.470Z",
      "location_count": 4,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00830531"
    },
    {
      "nct_id": "NCT04772222",
      "title": "Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Hypoxic-Ischemic Encephalopathy",
        "Pain"
      ],
      "interventions": [
        {
          "name": "Dexmedetomidine Hydrochloride",
          "type": "DRUG"
        },
        {
          "name": "Morphine Sulfate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Utah",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "24 Hours",
        "sex": "ALL",
        "summary": "Up to 24 Hours"
      },
      "enrollment_count": 50,
      "start_date": "2022-06-20",
      "completion_date": "2025-12-31",
      "has_results": true,
      "last_update_posted_date": "2026-03-06",
      "last_synced_at": "2026-06-10T23:26:49.470Z",
      "location_count": 5,
      "location_summary": "Murray, Utah • Ogden, Utah • Provo, Utah + 1 more",
      "locations": [
        {
          "city": "Murray",
          "state": "Utah"
        },
        {
          "city": "Ogden",
          "state": "Utah"
        },
        {
          "city": "Provo",
          "state": "Utah"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04772222"
    },
    {
      "nct_id": "NCT00383305",
      "title": "CoolCap Trial, Treatment of Perinatal Hypoxic-Ischemic Encephalopathy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Neonatal Hypoxic-Ischemic Encephalopathy (HIE)"
      ],
      "interventions": [
        {
          "name": "Cool-Cap",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Olympic Medical",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Hour",
        "maximum_age": "6 Hours",
        "sex": "ALL",
        "summary": "1 Hour to 6 Hours"
      },
      "enrollment_count": 235,
      "start_date": "1999-07",
      "completion_date": "2003-09",
      "has_results": false,
      "last_update_posted_date": "2006-10-03",
      "last_synced_at": "2026-06-10T23:26:49.470Z",
      "location_count": 19,
      "location_summary": "Little Rock, Arkansas • Oakland, California • San Diego, California + 15 more",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Oakland",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00383305"
    },
    {
      "nct_id": "NCT00006516",
      "title": "Home Stimulation for Brain-Asphyxiated Infants",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Hypoxia, Brain",
        "Hypoxia-Ischemia, Brain"
      ],
      "interventions": [
        {
          "name": "Infant stimulation",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "1 Month",
        "sex": "ALL",
        "summary": "Up to 1 Month"
      },
      "enrollment_count": 120,
      "start_date": "1999-09",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2016-09-26",
      "last_synced_at": "2026-06-10T23:26:49.470Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00006516"
    },
    {
      "nct_id": "NCT03549520",
      "title": "CEUS Evaluation of Hypoxic Ischemic Injury",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Hypoxic-Ischemic Encephalopathy",
        "Brain Ischemia Hypoxia"
      ],
      "interventions": [
        {
          "name": "Sulfur hexafluoride lipid-type A microspheres",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Children's Hospital of Philadelphia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Minute",
        "maximum_age": "18 Months",
        "sex": "ALL",
        "summary": "1 Minute to 18 Months"
      },
      "enrollment_count": 1,
      "start_date": "2020-12-01",
      "completion_date": "2024-05-07",
      "has_results": true,
      "last_update_posted_date": "2025-05-14",
      "last_synced_at": "2026-06-10T23:26:49.470Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03549520"
    }
  ]
}