{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Nicotine+E-Cigarette+Use",
    "query": {
      "condition": "Nicotine E-Cigarette Use"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 188,
    "total_pages": 19,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Nicotine+E-Cigarette+Use&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-26T03:18:38.878Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04568395",
      "title": "Acute Effects of TCIG vs ECIG in PLWH",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "E Cigarette Use",
        "Vaping",
        "Smoking",
        "Tobacco Smoking",
        "Nicotine Use Disorder",
        "Qt Interval, Variation in",
        "HIV I Infection",
        "Oxidative Stress",
        "Inflammation"
      ],
      "interventions": [
        {
          "name": "TCIG",
          "type": "OTHER"
        },
        {
          "name": "ECIG",
          "type": "OTHER"
        },
        {
          "name": "sham control",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "21 Years to 45 Years"
      },
      "enrollment_count": 37,
      "start_date": "2020-10-01",
      "completion_date": "2023-05-08",
      "has_results": false,
      "last_update_posted_date": "2023-10-04",
      "last_synced_at": "2026-06-26T03:18:38.878Z",
      "location_count": 2,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04568395"
    },
    {
      "nct_id": "NCT05932745",
      "title": "Effects of Novel E-cigarette Constituents on Adults TCORS 3.0",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nicotine Use Disorder"
      ],
      "interventions": [
        {
          "name": "E-liquid coolant (No WS-3) for non-menthol (1)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (No WS-3) for low (0.1%) menthol (1)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (No WS-3) for high (2.0%) menthol (1)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-3) for non-menthol (2)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-3) for low (0.1%) menthol (2)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-3) for high (2.0%) menthol (2)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-3) for non-menthol (3)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-3) for low (0.1%) menthol (3)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-3) for high (2.0%) menthol (3)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-23) for non-menthol (4)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-23) for low (0.1%) menthol (4)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-23) for high (2.0%) menthol (4)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-23) for non-menthol (5)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-23) for low (0.1%) menthol (5)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-23) for high (2.0%) menthol (5)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (4% WS-23) for non-menthol (6)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (4% WS-23) for low (0.1%) menthol (6)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (4% WS-23) for high (2.0%) menthol (6)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 66,
      "start_date": "2025-06-20",
      "completion_date": "2026-08",
      "has_results": false,
      "last_update_posted_date": "2026-06-16",
      "last_synced_at": "2026-06-26T03:18:38.878Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05932745"
    },
    {
      "nct_id": "NCT06862050",
      "title": "BREATHE Free: a Pilot Feasibility Trial",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking Cessation; Tobacco Dependence",
        "E-Cig Use",
        "Nicotine Dependence, Other Tobacco Product"
      ],
      "interventions": [
        {
          "name": "BREATHE Free Curriculum",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Augusta University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 90,
      "start_date": "2025-03-01",
      "completion_date": "2026-12-25",
      "has_results": false,
      "last_update_posted_date": "2025-03-06",
      "last_synced_at": "2026-06-26T03:18:38.878Z",
      "location_count": 1,
      "location_summary": "Augusta, Georgia",
      "locations": [
        {
          "city": "Augusta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06862050"
    },
    {
      "nct_id": "NCT03072628",
      "title": "E-cigarettes, Nicotine Inhaler, and Blood Vessel Function",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "e-cig with nicotine",
          "type": "OTHER"
        },
        {
          "name": "e-cig without nicotine",
          "type": "OTHER"
        },
        {
          "name": "nicotine inhaler",
          "type": "OTHER"
        },
        {
          "name": "sham control",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "21 Years to 45 Years"
      },
      "enrollment_count": 148,
      "start_date": "2017-01-11",
      "completion_date": "2022-12-01",
      "has_results": false,
      "last_update_posted_date": "2023-10-04",
      "last_synced_at": "2026-06-26T03:18:38.878Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03072628"
    },
    {
      "nct_id": "NCT04602494",
      "title": "Varenicline For Nicotine Vaping Cessation In Non Smoker Vaper Adolescents",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Vaping",
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "Varenicline",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "25 Years",
        "sex": "ALL",
        "summary": "18 Years to 25 Years"
      },
      "enrollment_count": 5,
      "start_date": "2020-12-18",
      "completion_date": "2022-06-27",
      "has_results": true,
      "last_update_posted_date": "2024-04-04",
      "last_synced_at": "2026-06-26T03:18:38.878Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04602494"
    },
    {
      "nct_id": "NCT03750825",
      "title": "Are Smokers Switching to Vaping at Lower Risk for Cancer? (Electronic Cigarettes and Cancer Risk)",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cigarette Smoking"
      ],
      "interventions": [
        {
          "name": "NIDA Standard Research E-cigarette (SREC)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Southern California",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "22 Years to 55 Years"
      },
      "enrollment_count": 150,
      "start_date": "2021-12-01",
      "completion_date": "2028-07-31",
      "has_results": false,
      "last_update_posted_date": "2025-08-06",
      "last_synced_at": "2026-06-26T03:18:38.878Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03750825"
    },
    {
      "nct_id": "NCT06765291",
      "title": "Behavioral Intervention for Youth to Promote Vaping Cessation",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Vaping",
        "Vaping Teens",
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "QuitVaping",
          "type": "BEHAVIORAL"
        },
        {
          "name": "This is Quitting (TIQ)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "14 Years to 18 Years"
      },
      "enrollment_count": 400,
      "start_date": "2025-06-18",
      "completion_date": "2028-09-27",
      "has_results": false,
      "last_update_posted_date": "2025-10-22",
      "last_synced_at": "2026-06-26T03:18:38.878Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06765291"
    },
    {
      "nct_id": "NCT03449017",
      "title": "Reactions to E-cigs and Alcohol",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Alcohol Abuse",
        "Nicotine Dependence Tobacco Product"
      ],
      "interventions": [
        {
          "name": "E-cig use",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 35,
      "start_date": "2017-03-24",
      "completion_date": "2018-11-11",
      "has_results": false,
      "last_update_posted_date": "2018-11-29",
      "last_synced_at": "2026-06-26T03:18:38.878Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03449017"
    },
    {
      "nct_id": "NCT03491059",
      "title": "Feasibility of PET/CT to Detect the Oral/Pulmonary Distribution of Nicotine Following E-cigarette Use",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "E-cigarette Use"
      ],
      "interventions": [
        {
          "name": "C-11 labeled nicotine",
          "type": "DRUG"
        },
        {
          "name": "PET/CT imaging",
          "type": "RADIATION"
        }
      ],
      "intervention_types": [
        "DRUG",
        "RADIATION"
      ],
      "sponsor": "University of Cincinnati",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 2,
      "start_date": "2018-02-16",
      "completion_date": "2025-02-16",
      "has_results": false,
      "last_update_posted_date": "2024-01-18",
      "last_synced_at": "2026-06-26T03:18:38.878Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03491059"
    },
    {
      "nct_id": "NCT05999383",
      "title": "Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "THC",
        "Cannabis",
        "Cannabis Use",
        "Cannabis Smoking",
        "Tobacco Use",
        "Vaping"
      ],
      "interventions": [
        {
          "name": "Cannabis",
          "type": "DRUG"
        },
        {
          "name": "Nicotine",
          "type": "DRUG"
        },
        {
          "name": "Pax Loose Leaf Vaporizer",
          "type": "DEVICE"
        },
        {
          "name": "Placebo Marijuana",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 48,
      "start_date": "2025-07-01",
      "completion_date": "2028-02-01",
      "has_results": false,
      "last_update_posted_date": "2026-01-07",
      "last_synced_at": "2026-06-26T03:18:38.878Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05999383"
    }
  ]
}