{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Non-Fluent+Primary+Progressive+Aphasia",
    "query": {
      "condition": "Non-Fluent Primary Progressive Aphasia"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 16,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Non-Fluent+Primary+Progressive+Aphasia&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T08:11:27.038Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02365922",
      "title": "Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "FTLD",
        "Progressive Supranuclear Palsy (PSP)",
        "Frontotemporal Dementia (FTD)",
        "Corticobasal Degeneration (CBD)",
        "PPA Syndrome",
        "Behavioral Variant Frontotemporal Dementia (bvFTD)",
        "Semantic Variant Primary Progressive Aphasia (svPPA)",
        "Nonfluent Variant Primary Progressive Aphasia (nfvPPA)",
        "FTD With Amyotrophic Lateral Sclerosis (FTD/ALS)",
        "Amyotrophic Lateral Sclerosis (ALS)",
        "Oligosymptomatic PSP (oPSP)",
        "Corticobasal Syndrome (CBS)"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 1489,
      "start_date": "2014-09",
      "completion_date": "2020-09",
      "has_results": false,
      "last_update_posted_date": "2021-05-21",
      "last_synced_at": "2026-05-22T08:11:27.038Z",
      "location_count": 15,
      "location_summary": "Birmingham, Alabama • Los Angeles, California • San Diego, California + 12 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Jacksonville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02365922"
    },
    {
      "nct_id": "NCT01623284",
      "title": "PiB PET Scanning in Speech and Language Based Dementias",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "PPA",
        "Primary Progressive Aphasia",
        "Aphasia",
        "Non-fluent Aphasia",
        "Semantic Dementia",
        "Apraxia of Speech",
        "Primary Progressive Nonfluent Aphasia",
        "Progressive Aphasia"
      ],
      "interventions": [
        {
          "name": "C-11 PiB",
          "type": "DRUG"
        },
        {
          "name": "F-18 FDG",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 168,
      "start_date": "2010-03",
      "completion_date": "2015-01",
      "has_results": false,
      "last_update_posted_date": "2015-12-22",
      "last_synced_at": "2026-05-22T08:11:27.038Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01623284"
    },
    {
      "nct_id": "NCT04881617",
      "title": "Treatment for Speech and Language in Primary Progressive Aphasia",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Primary Progressive Aphasia",
        "Semantic Dementia",
        "Semantic Memory Disorder",
        "Logopenic Progressive Aphasia",
        "Nonfluent Aphasia, Progressive",
        "Aphasia",
        "Aphasia, Progressive"
      ],
      "interventions": [
        {
          "name": "Lexical Retrieval Training (LRT)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Video-Implemented Script Training for Aphasia (VISTA)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Texas at Austin",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 60,
      "start_date": "2017-07-01",
      "completion_date": "2025-12-30",
      "has_results": false,
      "last_update_posted_date": "2025-11-13",
      "last_synced_at": "2026-05-22T08:11:27.038Z",
      "location_count": 2,
      "location_summary": "San Francisco, California • Austin, Texas",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Austin",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04881617"
    },
    {
      "nct_id": "NCT00537004",
      "title": "Language in Primary Progressive Aphasia",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Primary Progressive Aphasia"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Northwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 500,
      "start_date": "2007-05",
      "completion_date": "2027-04",
      "has_results": false,
      "last_update_posted_date": "2026-02-27",
      "last_synced_at": "2026-05-22T08:11:27.038Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00537004"
    },
    {
      "nct_id": "NCT03658135",
      "title": "BIIB092 in Primary Tauopathies: CBS, nfvPPA, sMAPT, and TES",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Primary Tauopathies",
        "Corticobasal Degeneration Syndrome",
        "Frontotemporal Lobar Degeneration With Tau Inclusions",
        "MAPT Mutation Carriers, Symptomatic",
        "Traumatic Encephalopathy Syndrome",
        "Nonfluent Aphasia, Progressive"
      ],
      "interventions": [
        {
          "name": "BIIB092",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "35 Years to 80 Years"
      },
      "enrollment_count": 22,
      "start_date": "2018-09-12",
      "completion_date": "2019-12-13",
      "has_results": false,
      "last_update_posted_date": "2019-12-19",
      "last_synced_at": "2026-05-22T08:11:27.038Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03658135"
    },
    {
      "nct_id": "NCT03406429",
      "title": "rTMS as a Treatment for PPA",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Logopenic Variant Primary Progressive Aphasia",
        "Non-Fluent Primary Progressive Aphasia"
      ],
      "interventions": [
        {
          "name": "Active rTMS",
          "type": "DEVICE"
        },
        {
          "name": "SHAM rTMS",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 12,
      "start_date": "2019-12-01",
      "completion_date": "2022-01-01",
      "has_results": false,
      "last_update_posted_date": "2022-04-07",
      "last_synced_at": "2026-05-22T08:11:27.038Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03406429"
    },
    {
      "nct_id": "NCT04188067",
      "title": "TMS for the Treatment of Primary Progressive Aphasia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Logopenic Variant Primary Progressive Aphasia",
        "Non-fluent Variant Primary Progressive Aphasia",
        "Semantic Variant Primary Progressive Aphasia"
      ],
      "interventions": [
        {
          "name": "Active rTMS",
          "type": "DEVICE"
        },
        {
          "name": "SHAM rTMS",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 10,
      "start_date": "2022-03-01",
      "completion_date": "2024-08-25",
      "has_results": true,
      "last_update_posted_date": "2026-04-01",
      "last_synced_at": "2026-05-22T08:11:27.038Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04188067"
    },
    {
      "nct_id": "NCT01056965",
      "title": "Davunetide (AL-108) in Predicted Tauopathies - Pilot Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Predicted Tauopathies, Including",
        "Progressive Supranuclear Palsy",
        "Frontotemporal Dementia With Parkinsonism Linked to Chromosome 17",
        "Corticobasal Degeneration Syndrome",
        "Progressive Nonfluent Aphasia"
      ],
      "interventions": [
        {
          "name": "davunetide (AL-108, NAP)",
          "type": "DRUG"
        },
        {
          "name": "Placebo nasal spray",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "40 Years to 85 Years"
      },
      "enrollment_count": 12,
      "start_date": "2010-01",
      "completion_date": "2012-12",
      "has_results": false,
      "last_update_posted_date": "2019-04-05",
      "last_synced_at": "2026-05-22T08:11:27.038Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01056965"
    },
    {
      "nct_id": "NCT01818661",
      "title": "Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "PPA",
        "Non-fluent Aphasia",
        "Apraxia of Speech",
        "Primary Progressive Non-fluent Aphasia",
        "Primary Progressive Aphasia"
      ],
      "interventions": [
        {
          "name": "AV-1451",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2018-07-01",
      "completion_date": "2028-06",
      "has_results": false,
      "last_update_posted_date": "2025-11-12",
      "last_synced_at": "2026-05-22T08:11:27.038Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01818661"
    },
    {
      "nct_id": "NCT05386394",
      "title": "Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Primary Progressive Aphasia",
        "Logopenic Progressive Aphasia",
        "Non-Fluent Primary Progressive Aphasia"
      ],
      "interventions": [
        {
          "name": "Active tDCS + Language Therapy",
          "type": "DEVICE"
        },
        {
          "name": "Sham tDCS + Language Therapy",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "50 Years to 90 Years"
      },
      "enrollment_count": 180,
      "start_date": "2024-02-13",
      "completion_date": "2028-02-01",
      "has_results": false,
      "last_update_posted_date": "2026-05-05",
      "last_synced_at": "2026-05-22T08:11:27.038Z",
      "location_count": 2,
      "location_summary": "Baltimore, Maryland • Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05386394"
    }
  ]
}