{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Nonfluent+Aphasia",
    "query": {
      "condition": "Nonfluent Aphasia"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 35,
    "total_pages": 4,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Nonfluent+Aphasia&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T08:53:11.794Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00537004",
      "title": "Language in Primary Progressive Aphasia",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Primary Progressive Aphasia"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Northwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 500,
      "start_date": "2007-05",
      "completion_date": "2027-04",
      "has_results": false,
      "last_update_posted_date": "2026-02-27",
      "last_synced_at": "2026-07-22T08:53:11.794Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00537004"
    },
    {
      "nct_id": "NCT06649084",
      "title": "Primary Progressive Aphasia Multicomponent Language Treatment Study",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Primary Progressive Aphasia",
        "Semantic Dementia",
        "Semantic Memory Disorder",
        "Logopenic Progressive Aphasia",
        "Nonfluent Aphasia, Progressive",
        "Aphasia",
        "Aphasia, Progressive"
      ],
      "interventions": [
        {
          "name": "Multicomponent Lexical Retrieval Training (Multi-LRT)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Multicomponent Communication Partner Training (Multi-CPT)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Texas at Austin",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 21,
      "start_date": "2023-05-02",
      "completion_date": "2025-12-31",
      "has_results": false,
      "last_update_posted_date": "2025-10-08",
      "last_synced_at": "2026-07-22T08:53:11.794Z",
      "location_count": 1,
      "location_summary": "Austin, Texas",
      "locations": [
        {
          "city": "Austin",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06649084"
    },
    {
      "nct_id": "NCT07033481",
      "title": "Clinical Study of Neflamapimod in Patients With Primary Progressive Aphasia",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Nonfluent Variant Primary Progressive Aphasia (nfvPPA)"
      ],
      "interventions": [
        {
          "name": "Neflamapimod",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "EIP Pharma Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "40 Years to 85 Years"
      },
      "enrollment_count": 20,
      "start_date": "2025-10-02",
      "completion_date": "2026-10",
      "has_results": false,
      "last_update_posted_date": "2026-07-06",
      "last_synced_at": "2026-07-22T08:53:11.794Z",
      "location_count": 5,
      "location_summary": "Chicago, Illinois • Rochester, Minnesota • New York, New York + 2 more",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07033481"
    },
    {
      "nct_id": "NCT01818661",
      "title": "Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "PPA",
        "Non-fluent Aphasia",
        "Apraxia of Speech",
        "Primary Progressive Non-fluent Aphasia",
        "Primary Progressive Aphasia"
      ],
      "interventions": [
        {
          "name": "AV-1451",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2018-07-01",
      "completion_date": "2028-06",
      "has_results": false,
      "last_update_posted_date": "2025-11-12",
      "last_synced_at": "2026-07-22T08:53:11.794Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01818661"
    },
    {
      "nct_id": "NCT02226796",
      "title": "Transcranial Direct Stimulation (tDCS) and Behavioral Intervention in Aphasia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aphasia"
      ],
      "interventions": [
        {
          "name": "Transcranial direct current stimulation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "20 Years to 85 Years"
      },
      "enrollment_count": 3,
      "start_date": "2015-09-01",
      "completion_date": "2018-12-01",
      "has_results": true,
      "last_update_posted_date": "2022-10-18",
      "last_synced_at": "2026-07-22T08:53:11.794Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02226796"
    },
    {
      "nct_id": "NCT04471935",
      "title": "Speech Hero Home Therapy for Aphasia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Broca Aphasia"
      ],
      "interventions": [
        {
          "name": "At home Speech Hero therapy app",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Flint Rehabilitation Devices, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 10,
      "start_date": "2021-07-20",
      "completion_date": "2021-10-20",
      "has_results": true,
      "last_update_posted_date": "2022-02-07",
      "last_synced_at": "2026-07-22T08:53:11.794Z",
      "location_count": 1,
      "location_summary": "Richardson, Texas",
      "locations": [
        {
          "city": "Richardson",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04471935"
    },
    {
      "nct_id": "NCT01927302",
      "title": "Neurobiology of Language Recovery in Aphasia: Natural History and Treatment-Induced Recovery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aphasia",
        "Dysgraphia",
        "Anomia",
        "Agrammatism",
        "Stroke"
      ],
      "interventions": [
        {
          "name": "Treatment Focusing on Naming Objects",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Treatment Focusing on Improving Spelling Abilities",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Treatment Focusing on Improving Sentence Processing",
          "type": "BEHAVIORAL"
        },
        {
          "name": "No Treatment",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Northwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "35 Years to 80 Years"
      },
      "enrollment_count": 90,
      "start_date": "2013-04",
      "completion_date": "2019-03-27",
      "has_results": false,
      "last_update_posted_date": "2026-07-01",
      "last_synced_at": "2026-07-22T08:53:11.794Z",
      "location_count": 4,
      "location_summary": "Chicago, Illinois • Baltimore, Maryland • Boston, Massachusetts + 1 more",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Cambridge",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01927302"
    },
    {
      "nct_id": "NCT07219680",
      "title": "Intervention for Communication Quality of Life in Primary Progressive Aphasia",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Primary Progressive Aphasia(PPA)",
        "Semantic Dementia",
        "Logopenic Progressive Aphasia (LPA)",
        "Nonfluent Aphasia, Progressive",
        "Progressive Aphasia",
        "Semantic Variant Primary Progressive Aphasia (svPPA)",
        "Semantic Aphasia",
        "Logopenic Variant Primary Progressive Aphasia",
        "Logopenic Variant of Primary Progressive Aphasia (LPA)",
        "Logopenic Progressive Aphasia",
        "Nonfluent Variant Primary Progressive Aphasia (nfvPPA)",
        "Nonfluent Progressive Aphasia"
      ],
      "interventions": [
        {
          "name": "Multicomponent Lexical Retrieval Cascade Training",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Multicomponent Video Implemented Script Training in Aphasia",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Maya Henry",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2026-04-01",
      "completion_date": "2027-08",
      "has_results": false,
      "last_update_posted_date": "2026-04-21",
      "last_synced_at": "2026-07-22T08:53:11.794Z",
      "location_count": 1,
      "location_summary": "Austin, Texas",
      "locations": [
        {
          "city": "Austin",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07219680"
    },
    {
      "nct_id": "NCT00903266",
      "title": "Melodic-Intonation-Therapy and Speech-Repetition-Therapy for Patients With Non-fluent Aphasia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Aphasia",
        "Stroke",
        "Cerebrovascular Accident",
        "Apoplexy",
        "Cerebral Infarction"
      ],
      "interventions": [
        {
          "name": "Melodic Intonation Therapy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Speech-Repetition-Therapy",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Beth Israel Deaconess Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "21 Years to 80 Years"
      },
      "enrollment_count": 30,
      "start_date": "2008-02",
      "completion_date": "2020-06",
      "has_results": false,
      "last_update_posted_date": "2020-09-21",
      "last_synced_at": "2026-07-22T08:53:11.794Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00903266"
    },
    {
      "nct_id": "NCT02514044",
      "title": "Dextroamphetamine and tDCS to Improve the Fluency",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Stroke"
      ],
      "interventions": [
        {
          "name": "Dexedrine",
          "type": "DRUG"
        },
        {
          "name": "Active tDCS",
          "type": "DEVICE"
        },
        {
          "name": "Speech Therapy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        },
        {
          "name": "Sham tDCS",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE",
        "BEHAVIORAL"
      ],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 10,
      "start_date": "2015-03",
      "completion_date": "2015-12",
      "has_results": true,
      "last_update_posted_date": "2018-08-03",
      "last_synced_at": "2026-07-22T08:53:11.794Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02514044"
    }
  ]
}