{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Normoxia",
    "query": {
      "condition": "Normoxia"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 9,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-06T07:32:30.051Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04452188",
      "title": "Targeting Normoxia in Neonates With Cyanotic Congenital Heart Disease in the Intra-operative and Immediate Post-operative Period",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypoplastic Left Heart Syndrome",
        "Total Anomalous Pulmonary Venous Return",
        "Truncus Arteriosus",
        "Pulmonary Atresia With Ventricular Septal Defect",
        "Transposition of the Great Arteries",
        "Double Outlet Right Ventricle, Subpulmonary VSD",
        "Tetralogy of Fallot",
        "Double Outlet Right Ventricle With Subaortic Ventricular Septal Defect and Pulmonary Stenosis",
        "Cardiopulmonary Bypass"
      ],
      "interventions": [
        {
          "name": "Normoxia (with controlled re-oxygenation)",
          "type": "OTHER"
        },
        {
          "name": "Standard of care ventilation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "29 Days",
        "sex": "ALL",
        "summary": "Up to 29 Days"
      },
      "enrollment_count": 29,
      "start_date": "2021-01-18",
      "completion_date": "2023-04-20",
      "has_results": true,
      "last_update_posted_date": "2024-06-18",
      "last_synced_at": "2026-09-06T07:32:30.051Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04452188"
    },
    {
      "nct_id": "NCT03789396",
      "title": "Pilot Study of Targeted Normoxia in Critically Ill Trauma Patients",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Trauma",
        "Critical Illness",
        "Oxygen Toxicity"
      ],
      "interventions": [
        {
          "name": "Targeted Normoxia (oxygen saturation 90-96%)",
          "type": "OTHER"
        },
        {
          "name": "Usual Care Oxygenation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "109 Years",
        "sex": "ALL",
        "summary": "18 Years to 109 Years"
      },
      "enrollment_count": 572,
      "start_date": "2018-01-01",
      "completion_date": "2022-10-01",
      "has_results": true,
      "last_update_posted_date": "2024-02-15",
      "last_synced_at": "2026-09-06T07:32:30.051Z",
      "location_count": 1,
      "location_summary": "Aurora, Colorado",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03789396"
    },
    {
      "nct_id": "NCT01905696",
      "title": "The Role of S-nitrosohemoglobin in Regulating Systemic Blood Flow During Hypoxia and Normoxia",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Focus is Determination of the Role of SNO-Hb in Forearm Blood Flow Regulation"
      ],
      "interventions": [
        {
          "name": "Oral N-acetylcysteine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 10,
      "start_date": "2013-03",
      "completion_date": "2013-08",
      "has_results": false,
      "last_update_posted_date": "2016-12-29",
      "last_synced_at": "2026-09-06T07:32:30.051Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01905696"
    },
    {
      "nct_id": "NCT06374225",
      "title": "Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration Intervention",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Critical Illness",
        "Wounds and Injury",
        "Disease Attributes",
        "Pathologic Processes"
      ],
      "interventions": [
        {
          "name": "Automated Titration (O2matic)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 300,
      "start_date": "2024-04-29",
      "completion_date": "2026-01-09",
      "has_results": false,
      "last_update_posted_date": "2026-04-29",
      "last_synced_at": "2026-09-06T07:32:30.051Z",
      "location_count": 4,
      "location_summary": "Aurora, Colorado • Winston-Salem, North Carolina • Portland, Oregon + 1 more",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06374225"
    },
    {
      "nct_id": "NCT03993002",
      "title": "DAMP-Mediated Innate Immune Failure and Pneumonia After Trauma - the Harvard-Longwood (HALO) Campus Area Consortium",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "Normoxia with Normocarbia",
          "type": "OTHER"
        },
        {
          "name": "Normoxia with Hypercarbia",
          "type": "OTHER"
        },
        {
          "name": "Hyperoxia with Normocarbia",
          "type": "OTHER"
        },
        {
          "name": "Hyperoxia with Hypercarbia",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Beth Israel Deaconess Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1,
      "start_date": "2019-11-15",
      "completion_date": "2021-10-01",
      "has_results": false,
      "last_update_posted_date": "2022-03-18",
      "last_synced_at": "2026-09-06T07:32:30.051Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03993002"
    },
    {
      "nct_id": "NCT05463042",
      "title": "Intermittent Hypoxia and Balance Control",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Intermittent Hypoxia",
        "Normoxia"
      ],
      "interventions": [
        {
          "name": "Intermittent Hypoxia",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Normoxia (sham)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Texas at Austin",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 3,
      "start_date": "2022-09-01",
      "completion_date": "2023-08-21",
      "has_results": false,
      "last_update_posted_date": "2023-11-29",
      "last_synced_at": "2026-09-06T07:32:30.051Z",
      "location_count": 1,
      "location_summary": "Austin, Texas",
      "locations": [
        {
          "city": "Austin",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05463042"
    },
    {
      "nct_id": "NCT04534972",
      "title": "Strategy to Avoid Excessive Oxygen in Major Burn Patients",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Critical Illness",
        "Wounds and Injury",
        "Disease Attributes",
        "Pathologic Processes"
      ],
      "interventions": [
        {
          "name": "Targeting Normoxemia (SpO2 90-96%; PaO2 60-100 mmHg)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "120 Years",
        "sex": "ALL",
        "summary": "18 Years to 120 Years"
      },
      "enrollment_count": 2000,
      "start_date": "2021-04-15",
      "completion_date": "2025-12-31",
      "has_results": false,
      "last_update_posted_date": "2025-04-02",
      "last_synced_at": "2026-09-06T07:32:30.051Z",
      "location_count": 6,
      "location_summary": "Birmingham, Alabama • Aurora, Colorado • Cincinnati, Ohio + 3 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Cincinnati",
          "state": "Ohio"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04534972"
    },
    {
      "nct_id": "NCT04534959",
      "title": "Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Critical Illness",
        "Wounds and Injury",
        "Disease Attributes",
        "Pathologic Processes"
      ],
      "interventions": [
        {
          "name": "Targeting Normoxemia (SpO2 90-96%; PaO2 60-100 mmHg)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "120 Years",
        "sex": "ALL",
        "summary": "18 Years to 120 Years"
      },
      "enrollment_count": 6000,
      "start_date": "2020-10-15",
      "completion_date": "2025-06-30",
      "has_results": false,
      "last_update_posted_date": "2025-04-02",
      "last_synced_at": "2026-09-06T07:32:30.051Z",
      "location_count": 8,
      "location_summary": "Birmingham, Alabama • Denver, Colorado • Cincinnati, Ohio + 5 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Cincinnati",
          "state": "Ohio"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04534959"
    },
    {
      "nct_id": "NCT03645031",
      "title": "Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amyotrophic Lateral Sclerosis (ALS)",
        "Neuromuscular Diseases"
      ],
      "interventions": [
        {
          "name": "Acute Intermittent Hypoxia",
          "type": "OTHER"
        },
        {
          "name": "Sham Acute Intermittent Hypoxia",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "21 Years to 75 Years"
      },
      "enrollment_count": 29,
      "start_date": "2018-10-01",
      "completion_date": "2023-06-02",
      "has_results": true,
      "last_update_posted_date": "2025-05-15",
      "last_synced_at": "2026-09-06T07:32:30.051Z",
      "location_count": 2,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        },
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03645031"
    }
  ]
}