{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Nuclear+Sclerosis",
    "query": {
      "condition": "Nuclear Sclerosis"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 16,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Nuclear+Sclerosis&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T08:21:36.627Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01878838",
      "title": "The Comparison of Cataract Lasers Using the Optimedica Catalys Laser and the Alcon LenSx Laser.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nuclear Sclerosis of the Lens",
        "Posterior Subcapsular Cataract",
        "Cortical Cataract"
      ],
      "interventions": [
        {
          "name": "Femtosecond Laser Assisted Cataract Surgery w/ Catalys Laser",
          "type": "PROCEDURE"
        },
        {
          "name": "Femtosecond Laser Assisted Cataract Surgery w/ LenSx Laser",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Steven H. Linn, OD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "22 Years and older"
      },
      "enrollment_count": 45,
      "start_date": "2013-04",
      "completion_date": "2014-01",
      "has_results": false,
      "last_update_posted_date": "2025-03-11",
      "last_synced_at": "2026-05-22T08:21:36.627Z",
      "location_count": 1,
      "location_summary": "Salt Lake City, Utah",
      "locations": [
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01878838"
    },
    {
      "nct_id": "NCT07223866",
      "title": "The Impact of Physiologic Cataract Surgery on Patient Comfort and Medication Usage",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cataract and IOL Surgery",
        "Cataract Surgery Anesthesia",
        "Cataract Surgery Experience",
        "Nuclear Cataract"
      ],
      "interventions": [
        {
          "name": "High IOP Setting",
          "type": "DEVICE"
        },
        {
          "name": "Low IOP Setting",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Matthew Rauen",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "60 Years and older"
      },
      "enrollment_count": 85,
      "start_date": "2025-11-01",
      "completion_date": "2027-01-01",
      "has_results": false,
      "last_update_posted_date": "2025-11-10",
      "last_synced_at": "2026-05-22T08:21:36.627Z",
      "location_count": 1,
      "location_summary": "West Des Moines, Iowa",
      "locations": [
        {
          "city": "West Des Moines",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07223866"
    },
    {
      "nct_id": "NCT04975971",
      "title": "A Retrospective Review of DEXTENZA 0.4 mg inseRt Following Corneal Transplant or Cataract Surgery",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Anterior Chamber Inflammation",
        "Ocular Pain",
        "Corneal Edema",
        "Corneal Defect",
        "Penetrating KeratoPlasty",
        "Nuclear Cataract",
        "Cortical Cataract",
        "Cataract Senile"
      ],
      "interventions": [
        {
          "name": "Dextenza 0.4Mg Ophthalmic Insert",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Nicole Fram M.D.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 25,
      "start_date": "2021-03-09",
      "completion_date": "2021-05-19",
      "has_results": false,
      "last_update_posted_date": "2021-07-26",
      "last_synced_at": "2026-05-22T08:21:36.627Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04975971"
    },
    {
      "nct_id": "NCT03819842",
      "title": "Evaluating the Need for the Pseudophakic Intraoperative Abberrometry in Toric IOL Implantation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cataract",
        "Nuclear Sclerosis",
        "Cortical Cataract",
        "Posterior Subcapsular Cataract",
        "Astigmatism"
      ],
      "interventions": [
        {
          "name": "Pseudophakic Measurement",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Alterman, Modi, & Wolter Ophthalmic Physicians & Surgeons",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "30 Years and older"
      },
      "enrollment_count": 40,
      "start_date": "2018-03-19",
      "completion_date": "2019-01-14",
      "has_results": false,
      "last_update_posted_date": "2022-01-20",
      "last_synced_at": "2026-05-22T08:21:36.627Z",
      "location_count": 1,
      "location_summary": "Poughkeepsie, New York",
      "locations": [
        {
          "city": "Poughkeepsie",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03819842"
    },
    {
      "nct_id": "NCT00333060",
      "title": "Study of OT-551 Eye Drops to Prevent or Delay Progression of Nuclear Cataracts Following Vitreous Removal",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Epiretinal Membrane",
        "Macular Hole"
      ],
      "interventions": [
        {
          "name": "OT-551 ophthalmic solution",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Othera Pharmaceuticals",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "50 Years and older"
      },
      "enrollment_count": 164,
      "start_date": "2005-11",
      "completion_date": "2008-01",
      "has_results": false,
      "last_update_posted_date": "2008-04-02",
      "last_synced_at": "2026-05-22T08:21:36.627Z",
      "location_count": 16,
      "location_summary": "Peoria, Arizona • Beverly Hills, California • Sacramento, California + 13 more",
      "locations": [
        {
          "city": "Peoria",
          "state": "Arizona"
        },
        {
          "city": "Beverly Hills",
          "state": "California"
        },
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00333060"
    },
    {
      "nct_id": "NCT06325397",
      "title": "Less Discomfort and Less Pharmacology. Cataract Surgery at Physiologic Intraocular Pressure (IOP)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Nuclear Cataract"
      ],
      "interventions": [
        {
          "name": "High Intraocular Pressure (IOP)",
          "type": "OTHER"
        },
        {
          "name": "Low Intraocular Pressure (IOP)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Matthew Rauen",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 65,
      "start_date": "2024-03-18",
      "completion_date": "2025-04-01",
      "has_results": false,
      "last_update_posted_date": "2025-05-21",
      "last_synced_at": "2026-05-22T08:21:36.627Z",
      "location_count": 1,
      "location_summary": "West Des Moines, Iowa",
      "locations": [
        {
          "city": "West Des Moines",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06325397"
    },
    {
      "nct_id": "NCT02131194",
      "title": "The Post-Vitrectomy Lenstatin™ Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cataract, Nuclear Progressive"
      ],
      "interventions": [
        {
          "name": "Lenstatin",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "DRUG"
      ],
      "sponsor": "Lenstatin LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2014-06",
      "completion_date": "2015-12",
      "has_results": false,
      "last_update_posted_date": "2015-12-04",
      "last_synced_at": "2026-05-22T08:21:36.627Z",
      "location_count": 1,
      "location_summary": "Wilmington, North Carolina",
      "locations": [
        {
          "city": "Wilmington",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02131194"
    },
    {
      "nct_id": "NCT02561104",
      "title": "Resident-Performed Laser-Assisted vs Manual Traditional Phacoemulsification Cataract Surgery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Incipient Cataract",
        "Senile Nuclear Sclerosis"
      ],
      "interventions": [
        {
          "name": "Laser-assisted cataract surgery.",
          "type": "PROCEDURE"
        },
        {
          "name": "Traditional manual phacoemulsification",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Texas Southwestern Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "21 Years to 99 Years"
      },
      "enrollment_count": 148,
      "start_date": "2015-12",
      "completion_date": "2018-06-19",
      "has_results": false,
      "last_update_posted_date": "2020-05-21",
      "last_synced_at": "2026-05-22T08:21:36.627Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02561104"
    },
    {
      "nct_id": "NCT06365762",
      "title": "The Safety and Efficacy Study of Ethylenediaminetetraacetic Acid (EDTA) Ophthalmic Solution in Patients With Loss of Contrast Sensitivity Due to Age-Related, Low-Grade Nuclear Cataract",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Age Related Cataracts"
      ],
      "interventions": [
        {
          "name": "EDTA Ophthalmic Solution 2.6%",
          "type": "DRUG"
        },
        {
          "name": "EDTA Ophthalmic Solution 1.3%",
          "type": "DRUG"
        },
        {
          "name": "Saline Solution (Placebo)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Livionex Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "50 Years and older"
      },
      "enrollment_count": 111,
      "start_date": "2006-01-01",
      "completion_date": "2007-04-30",
      "has_results": false,
      "last_update_posted_date": "2024-04-16",
      "last_synced_at": "2026-05-22T08:21:36.627Z",
      "location_count": 6,
      "location_summary": "San Francisco, California • Overland Park, Kansas • Lutherville, Maryland + 3 more",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Overland Park",
          "state": "Kansas"
        },
        {
          "city": "Lutherville",
          "state": "Maryland"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06365762"
    },
    {
      "nct_id": "NCT00078299",
      "title": "Evaluation of the Age-Related Eye Disease Study (AREDS) Clinical Lens Grading System",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cataract"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Eye Institute (NEI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 150,
      "start_date": "2004-02",
      "completion_date": "2005-04",
      "has_results": false,
      "last_update_posted_date": "2008-03-04",
      "last_synced_at": "2026-05-22T08:21:36.627Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00078299"
    }
  ]
}