{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=OA+Knee+Pain&page=2",
    "query": {
      "condition": "OA Knee Pain",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=OA+Knee+Pain&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-07-24T15:18:33.067Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00488267",
      "title": "Efficacy of ThermoProfen in Patients With Mild to Moderate Pain Associated With Osteoarthritis of the Knee",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "ThermoProfen™ (Matrix Transdermal Ketoprofen/CHADD™ System)",
          "type": "DRUG"
        },
        {
          "name": "Placebo Matrix/CHADD Patch",
          "type": "DRUG"
        },
        {
          "name": "Ketoprofen matrix/placebo CHADD Patch",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "ZARS Pharma Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 679,
      "start_date": "2007-06",
      "completion_date": "2008-09",
      "has_results": false,
      "last_update_posted_date": "2012-05-30",
      "last_synced_at": "2026-07-24T15:18:33.067Z",
      "location_count": 36,
      "location_summary": "Peoria, Arizona • Anaheim, California • Buena Park, California + 33 more",
      "locations": [
        {
          "city": "Peoria",
          "state": "Arizona"
        },
        {
          "city": "Anaheim",
          "state": "California"
        },
        {
          "city": "Buena Park",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Westlake Village",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00488267"
    },
    {
      "nct_id": "NCT02560922",
      "title": "Pain Coping Skills Training for African Americans With Osteoarthritis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "Pain Coping Skills Training (CST)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 248,
      "start_date": "2016-04",
      "completion_date": "2018-05-02",
      "has_results": true,
      "last_update_posted_date": "2019-04-01",
      "last_synced_at": "2026-07-24T15:18:33.067Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02560922"
    },
    {
      "nct_id": "NCT04814719",
      "title": "Treatment and Duration Effect of Pentosan Polysulfate Sodium (PPS) in Participants With Knee Osteoarthritis Pain",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Osteoarthritis, Knee"
      ],
      "interventions": [
        {
          "name": "Pentosan Polysulphate Sodium",
          "type": "DRUG"
        },
        {
          "name": "Placebo (Sodium Chloride Injection, 0.9%)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Paradigm Biopharmaceuticals Ltd.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 133,
      "start_date": "2023-06-24",
      "completion_date": "2024-12-24",
      "has_results": false,
      "last_update_posted_date": "2025-07-22",
      "last_synced_at": "2026-07-24T15:18:33.067Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04814719"
    },
    {
      "nct_id": "NCT03074526",
      "title": "Protocol for the Clinical Evaluation of Lyophilized Amniotic Fluid in the Treatment of Knee Osteoarthritis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis, Knee"
      ],
      "interventions": [
        {
          "name": "Amniotic Fluid",
          "type": "OTHER"
        },
        {
          "name": "Saline Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "MiMedx Group, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "30 Years and older"
      },
      "enrollment_count": 156,
      "start_date": "2017-01-23",
      "completion_date": "2018-04-25",
      "has_results": false,
      "last_update_posted_date": "2020-11-13",
      "last_synced_at": "2026-07-24T15:18:33.067Z",
      "location_count": 4,
      "location_summary": "Birmingham, Alabama • Atlanta, Georgia • Des Plaines, Illinois + 1 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Des Plaines",
          "state": "Illinois"
        },
        {
          "city": "Hinsdale",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03074526"
    },
    {
      "nct_id": "NCT03719417",
      "title": "A Biologic Joint Replacement Strategy for Knee Trauma and Post-Traumatic Osteoarthritis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Knee Osteoarthritis",
        "Post-traumatic Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "Unicompartmental Biologic Arthroplasty",
          "type": "PROCEDURE"
        },
        {
          "name": "Extensive Biologic Arthroplasty",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Missouri-Columbia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 14,
      "start_date": "2018-12-01",
      "completion_date": "2022-10-31",
      "has_results": false,
      "last_update_posted_date": "2022-11-02",
      "last_synced_at": "2026-07-24T15:18:33.067Z",
      "location_count": 1,
      "location_summary": "Columbia, Missouri",
      "locations": [
        {
          "city": "Columbia",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03719417"
    },
    {
      "nct_id": "NCT03381248",
      "title": "Cooled Radiofrequency vs. Hyaluronic Acid to Manage Knee Pain",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis of the Knee"
      ],
      "interventions": [
        {
          "name": "Cooled Radiofrequency",
          "type": "DEVICE"
        },
        {
          "name": "Hyaluronic Acid Injection",
          "type": "OTHER"
        },
        {
          "name": "Crossover from Hyaluronic Acid Injection to Cooled Radiofrequency",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Avanos Medical",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 177,
      "start_date": "2017-12-07",
      "completion_date": "2020-07-20",
      "has_results": true,
      "last_update_posted_date": "2023-10-10",
      "last_synced_at": "2026-07-24T15:18:33.067Z",
      "location_count": 10,
      "location_summary": "Coeur d'Alene, Idaho • New Orleans, Louisiana • Rochester, Minnesota + 7 more",
      "locations": [
        {
          "city": "Coeur d'Alene",
          "state": "Idaho"
        },
        {
          "city": "New Orleans",
          "state": "Louisiana"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        },
        {
          "city": "Edmond",
          "state": "Oklahoma"
        },
        {
          "city": "Altoona",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03381248"
    },
    {
      "nct_id": "NCT00080171",
      "title": "Osteoarthritis Initiative (OAI): A Knee Health Study",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Osteoarthritis",
        "Knee Osteoarthritis"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "45 Years",
        "maximum_age": "79 Years",
        "sex": "ALL",
        "summary": "45 Years to 79 Years"
      },
      "enrollment_count": 4796,
      "start_date": "2004-02",
      "completion_date": "2015-10",
      "has_results": false,
      "last_update_posted_date": "2020-09-29",
      "last_synced_at": "2026-07-24T15:18:33.067Z",
      "location_count": 5,
      "location_summary": "Baltimore, Maryland • Columbus, Ohio • Pittsburgh, Pennsylvania + 1 more",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        },
        {
          "city": "Pawtucket",
          "state": "Rhode Island"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00080171"
    },
    {
      "nct_id": "NCT04638387",
      "title": "PB125, Osteoarthritis, Pain, Mobility, and Energetics",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis, Knee",
        "Muscle Weakness",
        "Pain, Joint"
      ],
      "interventions": [
        {
          "name": "PB125",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Colorado State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "50 Years to 65 Years"
      },
      "enrollment_count": 4,
      "start_date": "2020-11-03",
      "completion_date": "2021-09-01",
      "has_results": false,
      "last_update_posted_date": "2022-09-14",
      "last_synced_at": "2026-07-24T15:18:33.067Z",
      "location_count": 1,
      "location_summary": "Fort Collins, Colorado",
      "locations": [
        {
          "city": "Fort Collins",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04638387"
    },
    {
      "nct_id": "NCT04343716",
      "title": "Investigating Racial Differences in Diet Benefits for Knee Osteoarthritis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Knee Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "Low-carbohydrate diet",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": "75 Years",
        "sex": "FEMALE",
        "summary": "65 Years to 75 Years · Female only"
      },
      "enrollment_count": 19,
      "start_date": "2020-10-01",
      "completion_date": "2023-09-18",
      "has_results": true,
      "last_update_posted_date": "2025-01-09",
      "last_synced_at": "2026-07-24T15:18:33.067Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04343716"
    },
    {
      "nct_id": "NCT04805190",
      "title": "Study of Pain Catastrophizing-2 (SPAC-2)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis, Knee"
      ],
      "interventions": [
        {
          "name": "Cognitive-Behavioral Intervention",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Pain Education",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "45 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "45 Years to 85 Years"
      },
      "enrollment_count": 99,
      "start_date": "2021-10-15",
      "completion_date": "2023-12-12",
      "has_results": false,
      "last_update_posted_date": "2024-05-14",
      "last_synced_at": "2026-07-24T15:18:33.067Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04805190"
    }
  ]
}