{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Ocular+Surface+Disease",
    "query": {
      "condition": "Ocular Surface Disease"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 93,
    "total_pages": 10,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Ocular+Surface+Disease&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T09:46:57.915Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00382122",
      "title": "Prevalence of Ocular Surface Disease in Glaucoma Patients",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Glaucoma"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Alcon Research",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 101,
      "start_date": "2006-09",
      "completion_date": "2007-02",
      "has_results": false,
      "last_update_posted_date": "2012-05-28",
      "last_synced_at": "2026-05-22T09:46:57.915Z",
      "location_count": 1,
      "location_summary": "La Jolla, California",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00382122"
    },
    {
      "nct_id": "NCT07502378",
      "title": "Effect of Acoltremon Ophthalmic Solution 0.003% on Signs and Symptoms of Ocular Surface Disease in Stage I Neurotrophic Keratopathy Patients With Tear Deficiency",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Ocular Surface Disease",
        "Neurotrophic Keratopathy Stage 1"
      ],
      "interventions": [
        {
          "name": "Patients will receive topical Acoltremon 0.003% ophthalmic solution BID in both eyes over an 8 week period.",
          "type": "DRUG"
        },
        {
          "name": "Alternative would be patient exiting the trial and starting on tears or other standard of care.",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "University of South Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2026-03-27",
      "completion_date": "2027-08-31",
      "has_results": false,
      "last_update_posted_date": "2026-03-31",
      "last_synced_at": "2026-05-22T09:46:57.915Z",
      "location_count": 1,
      "location_summary": "Tampa, Florida",
      "locations": [
        {
          "city": "Tampa",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07502378"
    },
    {
      "nct_id": "NCT03968731",
      "title": "Meibomian Gland Dysfunction Management With ZEST Protocol",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Meibomian Gland Dysfunction",
        "Dry Eye Syndromes",
        "Ocular Surface Disease"
      ],
      "interventions": [
        {
          "name": "Zocular Eyelid System Treatment",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of the Incarnate Word",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2019-06-10",
      "completion_date": "2020-05-31",
      "has_results": false,
      "last_update_posted_date": "2022-07-14",
      "last_synced_at": "2026-05-22T09:46:57.915Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03968731"
    },
    {
      "nct_id": "NCT07579156",
      "title": "TearCare in Young Adults",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Meibomian Gland Dysfunction (Disorder)"
      ],
      "interventions": [
        {
          "name": "TearCare®",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "29 Years",
        "sex": "ALL",
        "summary": "18 Years to 29 Years"
      },
      "enrollment_count": 45,
      "start_date": "2026-08-01",
      "completion_date": "2027-12-01",
      "has_results": false,
      "last_update_posted_date": "2026-05-11",
      "last_synced_at": "2026-05-22T09:46:57.915Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07579156"
    },
    {
      "nct_id": "NCT01797107",
      "title": "Study to Determine the Effect of Azasite on Corneal Surface Irregularity",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Meibomian Gland Dysfunction"
      ],
      "interventions": [
        {
          "name": "Azasite",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Philadelphia Eye Associates",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2013-03",
      "completion_date": "2014-07",
      "has_results": false,
      "last_update_posted_date": "2016-09-28",
      "last_synced_at": "2026-05-22T09:46:57.915Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01797107"
    },
    {
      "nct_id": "NCT04120987",
      "title": "Ocular Inflammation in Cataract Patients and Response to Treatment With Xiidra",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Dry Eye"
      ],
      "interventions": [
        {
          "name": "Lifitegrast 5% Ophthalmic Solution",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Bucci Laser Vision Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "60 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2021-05-31",
      "completion_date": "2022-06-25",
      "has_results": false,
      "last_update_posted_date": "2023-07-27",
      "last_synced_at": "2026-05-22T09:46:57.915Z",
      "location_count": 1,
      "location_summary": "Wilkes-Barre, Pennsylvania",
      "locations": [
        {
          "city": "Wilkes-Barre",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04120987"
    },
    {
      "nct_id": "NCT04735510",
      "title": "Novel Use of Restasis and PROSE Devices",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Ocular Surface Disease"
      ],
      "interventions": [
        {
          "name": "cyclosporine ophthalmic emulsion 0.05%",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Boston Sight",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2021-05",
      "completion_date": "2021-09",
      "has_results": false,
      "last_update_posted_date": "2023-04-19",
      "last_synced_at": "2026-05-22T09:46:57.915Z",
      "location_count": 1,
      "location_summary": "Needham, Massachusetts",
      "locations": [
        {
          "city": "Needham",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04735510"
    },
    {
      "nct_id": "NCT06364657",
      "title": "Differences in Corneal Structure and Function in Patients With Sjogrens vs. Non-Sjogrens Dry Eye",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Sjogren's Syndrome",
        "Dry Eye",
        "Neurotrophic Keratitis"
      ],
      "interventions": [
        {
          "name": "Eye Exam",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 13,
      "start_date": "2024-07-01",
      "completion_date": "2024-12-19",
      "has_results": false,
      "last_update_posted_date": "2025-01-15",
      "last_synced_at": "2026-05-22T09:46:57.915Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06364657"
    },
    {
      "nct_id": "NCT02592330",
      "title": "Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Limbal Stem Cell Deficiency"
      ],
      "interventions": [
        {
          "name": "Biopsy to collect limbal epithelial stem cells that will be cultivated into a graft",
          "type": "PROCEDURE"
        },
        {
          "name": "Cultivation of Limbal epithelial cells into a graft",
          "type": "BIOLOGICAL"
        },
        {
          "name": "CALEC Transplant",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "BIOLOGICAL"
      ],
      "sponsor": "Massachusetts Eye and Ear Infirmary",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 23,
      "start_date": "2016-08-01",
      "completion_date": "2023-03-31",
      "has_results": true,
      "last_update_posted_date": "2025-01-15",
      "last_synced_at": "2026-05-22T09:46:57.915Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02592330"
    },
    {
      "nct_id": "NCT02347631",
      "title": "DAILIES TOTAL1 Versus ACUVUE TruEye - Effects on the Biology of the Ocular Surface and Lid Margin",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Soft Contact Lenses",
        "Myopia"
      ],
      "interventions": [
        {
          "name": "Soft Contact Lens - Daily Disposable Alcon Dailies Total 1 and ACUVUE TruEye",
          "type": "DEVICE"
        },
        {
          "name": "Soft Contact Lens - Acuvue TruEye and Alcon DAILIES TOTAL 1.",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Texas Southwestern Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "38 Years",
        "sex": "ALL",
        "summary": "21 Years to 38 Years"
      },
      "enrollment_count": 118,
      "start_date": "2016-04",
      "completion_date": "2018-06",
      "has_results": true,
      "last_update_posted_date": "2020-12-10",
      "last_synced_at": "2026-05-22T09:46:57.915Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02347631"
    }
  ]
}