{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Open+Tibia+Fracture&page=2",
    "query": {
      "condition": "Open Tibia Fracture",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Open+Tibia+Fracture&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T05:44:09.324Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04299022",
      "title": "Safety, Efficacy, & Use of ViviGen Cellular Bone Matrix Allograft in Orthopaedic Fracture Care",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Fractures, Bone",
        "Nonunion of Fracture",
        "Fractures, Open",
        "Fractures, Ununited",
        "Fracture, Tibial",
        "Fracture of Femur",
        "Fracture Arm"
      ],
      "interventions": [
        {
          "name": "Vivigen Cellular Bone Matrix",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "LifeNet Health",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 250,
      "start_date": "2021-06-01",
      "completion_date": "2026-07-31",
      "has_results": false,
      "last_update_posted_date": "2025-04-02",
      "last_synced_at": "2026-05-22T05:44:09.324Z",
      "location_count": 4,
      "location_summary": "Orlando, Florida • Jersey City, New Jersey • Durham, North Carolina + 1 more",
      "locations": [
        {
          "city": "Orlando",
          "state": "Florida"
        },
        {
          "city": "Jersey City",
          "state": "New Jersey"
        },
        {
          "city": "Durham",
          "state": "North Carolina"
        },
        {
          "city": "Norfolk",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04299022"
    },
    {
      "nct_id": "NCT06639503",
      "title": "Genicular Nerve Block After Open Reduction Internal Fixation of Tibial Plateau",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Tibial Plateau Fractures"
      ],
      "interventions": [
        {
          "name": "Bupivacain",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 38,
      "start_date": "2024-11-01",
      "completion_date": "2026-10-14",
      "has_results": false,
      "last_update_posted_date": "2026-02-05",
      "last_synced_at": "2026-05-22T05:44:09.324Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06639503"
    },
    {
      "nct_id": "NCT03881241",
      "title": "Safety Study of Treatment of Leg Fractures",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Tibial Fractures"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Smith & Nephew, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 2,
      "start_date": "2019-09-20",
      "completion_date": "2020-03-24",
      "has_results": false,
      "last_update_posted_date": "2020-04-10",
      "last_synced_at": "2026-05-22T05:44:09.324Z",
      "location_count": 2,
      "location_summary": "Athens, Georgia • Fort Worth, Texas",
      "locations": [
        {
          "city": "Athens",
          "state": "Georgia"
        },
        {
          "city": "Fort Worth",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03881241"
    },
    {
      "nct_id": "NCT05402995",
      "title": "Randomized Trial Comparing Irrisept to Saline Irrigation for Infection Prevention",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Gustilo-Anderson Type III Open Tibia Fracture"
      ],
      "interventions": [
        {
          "name": "Irrisept (Irrigation Solution)",
          "type": "DRUG"
        },
        {
          "name": "Saline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Brett D. Crist",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 6,
      "start_date": "2022-06-21",
      "completion_date": "2023-08-31",
      "has_results": true,
      "last_update_posted_date": "2024-04-24",
      "last_synced_at": "2026-05-22T05:44:09.324Z",
      "location_count": 1,
      "location_summary": "Columbia, Missouri",
      "locations": [
        {
          "city": "Columbia",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05402995"
    },
    {
      "nct_id": "NCT05317676",
      "title": "Effect of Palmitoylethanolamide on Reducing Opioid Consumption for Below Knee Fracture Fixation",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Tibial Fractures",
        "Fibula Fracture",
        "Knee Fracture"
      ],
      "interventions": [
        {
          "name": "Palmitoylethanolamide",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of California, Irvine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2023-05",
      "completion_date": "2025-12",
      "has_results": false,
      "last_update_posted_date": "2023-05-09",
      "last_synced_at": "2026-05-22T05:44:09.324Z",
      "location_count": 1,
      "location_summary": "Orange, California",
      "locations": [
        {
          "city": "Orange",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05317676"
    },
    {
      "nct_id": "NCT00582998",
      "title": "Vacuum Assisted Closure as a Treatment for Soft Tissue Injuries",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Fracture of Calcaneus, Pilon or Tibial Plateau"
      ],
      "interventions": [
        {
          "name": "Standard Wound Dressing",
          "type": "PROCEDURE"
        },
        {
          "name": "Vacuum Assisted Closure Device",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DEVICE"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "19 Years and older"
      },
      "enrollment_count": 249,
      "start_date": "2001-06",
      "completion_date": "2007-03",
      "has_results": true,
      "last_update_posted_date": "2019-07-25",
      "last_synced_at": "2026-05-22T05:44:09.324Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00582998"
    },
    {
      "nct_id": "NCT00299052",
      "title": "Efficacy of DBM on Fractures of the Shinbone (Tibia)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Closed Fracture",
        "Open Fracture"
      ],
      "interventions": [
        {
          "name": "Grafton DBM",
          "type": "DEVICE"
        },
        {
          "name": "Reamings",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "BIOLOGICAL"
      ],
      "sponsor": "Emory University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 16,
      "start_date": "2006-03",
      "completion_date": "2008-09",
      "has_results": false,
      "last_update_posted_date": "2013-09-24",
      "last_synced_at": "2026-05-22T05:44:09.324Z",
      "location_count": 1,
      "location_summary": "Atlanta, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00299052"
    },
    {
      "nct_id": "NCT02820363",
      "title": "Study Evaluating CERAMENT™|G in Open Diaphyseal Tibial Fractures",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tibial Fracture"
      ],
      "interventions": [
        {
          "name": "CERAMENT|G",
          "type": "DEVICE"
        },
        {
          "name": "SOC treatment",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "PROCEDURE"
      ],
      "sponsor": "BONESUPPORT AB",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 201,
      "start_date": "2017-02-14",
      "completion_date": "2021-07-31",
      "has_results": false,
      "last_update_posted_date": "2021-08-10",
      "last_synced_at": "2026-05-22T05:44:09.324Z",
      "location_count": 17,
      "location_summary": "Birmingham, Alabama • Irvine, California • Los Angeles, California + 12 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Irvine",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02820363"
    },
    {
      "nct_id": "NCT01496014",
      "title": "Assessment of Severe Extremity Wound Bioburden at the Time of Definitive Wound Closure or Coverage",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Open Fracture"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Major Extremity Trauma Research Consortium",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "64 Years",
        "sex": "ALL",
        "summary": "18 Years to 64 Years"
      },
      "enrollment_count": 646,
      "start_date": "2011-09",
      "completion_date": "2022-06-30",
      "has_results": false,
      "last_update_posted_date": "2026-05-05",
      "last_synced_at": "2026-05-22T05:44:09.324Z",
      "location_count": 40,
      "location_summary": "San Diego, California • San Francisco, California • Denver, Colorado + 34 more",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01496014"
    },
    {
      "nct_id": "NCT00429585",
      "title": "A Multicenter Randomized Trial Comparing IM Nails and Plate Fixation in Proximal Tibial Fractures",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tibial Fractures"
      ],
      "interventions": [
        {
          "name": "reamed, interlocking intramedullary nail",
          "type": "DEVICE"
        },
        {
          "name": "locking periarticular plate",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Boston Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 108,
      "start_date": "2007-02",
      "completion_date": "2020-12-16",
      "has_results": true,
      "last_update_posted_date": "2021-11-02",
      "last_synced_at": "2026-05-22T05:44:09.324Z",
      "location_count": 27,
      "location_summary": "Birmingham, Alabama • Davis, California • San Francisco, California + 22 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Davis",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00429585"
    }
  ]
}