{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Orbital+Disease&page=4",
    "query": {
      "condition": "Orbital Disease",
      "page": 4
    },
    "page_size": 10
  },
  "pagination": {
    "page": 4,
    "page_size": 10,
    "total_count": 112,
    "total_pages": 12,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Orbital+Disease&page=5&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Orbital+Disease&page=3&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-22T01:53:23.439Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03298867",
      "title": "Treatment of Graves' Orbitopathy (Thyroid Eye Disease) to Reduce Proptosis With Teprotumumab Infusions in a Randomized, Placebo-Controlled, Clinical Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Thyroid Eye Disease",
        "Graves' Orbitopathy"
      ],
      "interventions": [
        {
          "name": "Teprotumumab",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "OTHER"
      ],
      "sponsor": "Amgen",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 83,
      "start_date": "2017-10-04",
      "completion_date": "2020-11-30",
      "has_results": true,
      "last_update_posted_date": "2024-07-11",
      "last_synced_at": "2026-10-22T01:53:23.439Z",
      "location_count": 9,
      "location_summary": "Beverly Hills, California • Los Angeles, California • Coral Gables, Florida + 6 more",
      "locations": [
        {
          "city": "Beverly Hills",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Coral Gables",
          "state": "Florida"
        },
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03298867"
    },
    {
      "nct_id": "NCT07623837",
      "title": "Clinical Validation of AI-Based Quantitative Eye Movement Analysis From Smartphone 9-Gaze Videos (Glandy EOM)",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Ocular Motility Disorders",
        "Strabismus",
        "Extraocular Muscle Dysfunction",
        "Thyroid Eye Disease"
      ],
      "interventions": [
        {
          "name": "Glandy EOM (AI-based quantitative eye movement analysis software)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "THYROSCOPE INC.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "22 Years and older"
      },
      "enrollment_count": 1000,
      "start_date": "2026-07-01",
      "completion_date": "2027-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-06-03",
      "last_synced_at": "2026-10-22T01:53:23.439Z",
      "location_count": 1,
      "location_summary": "San Jose, California",
      "locations": [
        {
          "city": "San Jose",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07623837"
    },
    {
      "nct_id": "NCT04080505",
      "title": "Does Potassium Iodide (SSKI) Reduce Vascularity in Graves' Thyroidectomy?",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Graves Disease"
      ],
      "interventions": [
        {
          "name": "SSKI- Potassium Iodide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Columbia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 29,
      "start_date": "2015-02-10",
      "completion_date": "2023-03-03",
      "has_results": true,
      "last_update_posted_date": "2024-09-19",
      "last_synced_at": "2026-10-22T01:53:23.439Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04080505"
    },
    {
      "nct_id": "NCT05635266",
      "title": "Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Age-Related Macular Degeneration",
        "Allergies",
        "Alpha-Gal Syndrome",
        "Alzheimer Disease",
        "Amyloidosis",
        "Ankylosing Spondylitis",
        "Arthritis",
        "Alopecia Areata",
        "Asthma",
        "Atopic Dermatitis",
        "Autism",
        "Autoimmune Hepatitis",
        "Behcet's Disease",
        "Beta-Thalassemia",
        "Cancer",
        "Celiac Disease",
        "Kidney Diseases",
        "COPD",
        "Crohn Disease",
        "Cystic Fibrosis",
        "Diabetes",
        "Dravet Syndrome",
        "DMD",
        "Fibromyalgia",
        "Graves Disease",
        "Thyroid Diseases",
        "Hepatitis",
        "Hidradenitis Suppurativa",
        "ITP",
        "Leukemia",
        "ALS",
        "Lupus or SLE",
        "Lymphoma",
        "Multiple Sclerosis",
        "Myasthenia Gravis",
        "Heart Diseases",
        "Parkinson Disease",
        "Pemphigus Vulgaris",
        "Cirrhosis",
        "Psoriasis",
        "Schizophrenia",
        "Scleroderma",
        "Sickle Cell Disease",
        "Stroke",
        "Ulcerative Colitis",
        "Vasculitis",
        "Vitiligo"
      ],
      "interventions": [
        {
          "name": "Specimen sample",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Sanguine Biosciences",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 20000,
      "start_date": "2021-10-26",
      "completion_date": "2025-10",
      "has_results": false,
      "last_update_posted_date": "2024-05-07",
      "last_synced_at": "2026-10-22T01:53:23.439Z",
      "location_count": 1,
      "location_summary": "Waltham, Massachusetts",
      "locations": [
        {
          "city": "Waltham",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05635266"
    },
    {
      "nct_id": "NCT06563856",
      "title": "A Study of TEPEZZA Subcutaneous Administration in Healthy Adults",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Bioavailability",
        "Bioequivalence"
      ],
      "interventions": [
        {
          "name": "TEPEZZA",
          "type": "DRUG"
        },
        {
          "name": "EDP",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Amgen",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 37,
      "start_date": "2020-09-22",
      "completion_date": "2021-05-27",
      "has_results": false,
      "last_update_posted_date": "2024-08-21",
      "last_synced_at": "2026-10-22T01:53:23.439Z",
      "location_count": 1,
      "location_summary": "Las Vegas, Nevada",
      "locations": [
        {
          "city": "Las Vegas",
          "state": "Nevada"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06563856"
    },
    {
      "nct_id": "NCT06179875",
      "title": "An Open-label Study (OLE) for Non-responders of VRDN-001-101 and VRDN-001-301",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Thyroid Eye Disease"
      ],
      "interventions": [
        {
          "name": "Veligrotug",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Viridian Therapeutics, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 139,
      "start_date": "2024-01-31",
      "completion_date": "2025-06-23",
      "has_results": true,
      "last_update_posted_date": "2026-08-14",
      "last_synced_at": "2026-10-22T01:53:23.439Z",
      "location_count": 18,
      "location_summary": "Los Angeles, California • Newport Beach, California • Palo Alto, California + 13 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Newport Beach",
          "state": "California"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06179875"
    },
    {
      "nct_id": "NCT06850857",
      "title": "Multi-Institutional IMPACT Validation",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Facial Injuries",
        "Mandible Fracture",
        "Le Fort",
        "Zygomaticomaxillary Complex Fracture",
        "Nasal Fracture",
        "Orbital Fractures",
        "Zygoma Fracture",
        "Orbital Floor Fracture",
        "Facial Laceration"
      ],
      "interventions": [
        {
          "name": "IMPACT-G Module",
          "type": "OTHER"
        },
        {
          "name": "IMPACT-N Module",
          "type": "OTHER"
        },
        {
          "name": "IMPACT-O Module",
          "type": "OTHER"
        },
        {
          "name": "IMPACT-J Module",
          "type": "OTHER"
        },
        {
          "name": "15D Control Survey",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Tennessee",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 500,
      "start_date": "2025-07-01",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2025-06-18",
      "last_synced_at": "2026-10-22T01:53:23.439Z",
      "location_count": 3,
      "location_summary": "Sacramento, California • San Francisco, California • Memphis, Tennessee",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Memphis",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06850857"
    },
    {
      "nct_id": "NCT02107794",
      "title": "Shared Decision Making in Graves Disease - Graves Disease (GD) Choice",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Graves' Disease",
        "Thyroid Disease",
        "Hyperthyroidism"
      ],
      "interventions": [
        {
          "name": "Decision Aid",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 93,
      "start_date": "2012-12",
      "completion_date": "2015-04",
      "has_results": false,
      "last_update_posted_date": "2015-04-07",
      "last_synced_at": "2026-10-22T01:53:23.439Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02107794"
    },
    {
      "nct_id": "NCT02339545",
      "title": "Coronary Flow Reserve Following Orbital Atherectomy",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Coronary Artery Disease"
      ],
      "interventions": [
        {
          "name": "Coronary Orbital Atherectomy plus Stenting",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Abbott Medical Devices",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 15,
      "start_date": "2015-02",
      "completion_date": "2016-05",
      "has_results": true,
      "last_update_posted_date": "2023-07-18",
      "last_synced_at": "2026-10-22T01:53:23.439Z",
      "location_count": 3,
      "location_summary": "Chandler, Arizona • Coon Rapids, Minnesota • Roslyn, New York",
      "locations": [
        {
          "city": "Chandler",
          "state": "Arizona"
        },
        {
          "city": "Coon Rapids",
          "state": "Minnesota"
        },
        {
          "city": "Roslyn",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02339545"
    },
    {
      "nct_id": "NCT05945784",
      "title": "Exploring Accessible Beauty for Individuals With Upper Extremity Deficits",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Stroke, Ischemic",
        "Stroke Hemorrhagic",
        "Stroke (CVA) or TIA",
        "Stroke, Acute",
        "Traumatic Brain Injury",
        "SCI - Spinal Cord Injury",
        "Ehlers-Danlos Syndromes (EDS)",
        "Lupus Erythematosus",
        "Guillain-Barre Syndrome",
        "Multiple Sclerosis",
        "Myasthenia Gravis",
        "Amyotrophic Lateral Sclerosis",
        "Graves Disease",
        "Muscular Dystrophies"
      ],
      "interventions": [
        {
          "name": "Use of Rare Beauty makeup products",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Casa Colina Hospital and Centers for Healthcare",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 57,
      "start_date": "2023-07-21",
      "completion_date": "2023-09-29",
      "has_results": false,
      "last_update_posted_date": "2023-12-06",
      "last_synced_at": "2026-10-22T01:53:23.439Z",
      "location_count": 1,
      "location_summary": "Pomona, California",
      "locations": [
        {
          "city": "Pomona",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05945784"
    }
  ]
}