{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Ornithine+Transcarbamylase+Deficiency+Disease",
    "query": {
      "condition": "Ornithine Transcarbamylase Deficiency Disease"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 28,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Ornithine+Transcarbamylase+Deficiency+Disease&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-10T09:32:50.059Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04908319",
      "title": "Hepatic Histopathology in Urea Cycle Disorders",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Urea Cycle Disorder",
        "Ornithine Transcarbamylase Deficiency",
        "Citrullinemia 1",
        "ARGI Deficiency",
        "ASL Deficiency",
        "Argininosuccinic Aciduria",
        "ASS Deficiency",
        "Hyperargininemia",
        "Carbamyl Phosphate Synthetase Deficiency",
        "NAGS Deficiency"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Baylor College of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 70,
      "start_date": "2022-02-24",
      "completion_date": "2026-06-30",
      "has_results": false,
      "last_update_posted_date": "2025-07-20",
      "last_synced_at": "2026-06-10T09:32:50.059Z",
      "location_count": 2,
      "location_summary": "Washington D.C., District of Columbia • Houston, Texas",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04908319"
    },
    {
      "nct_id": "NCT01663896",
      "title": "Observational Study of OCT in a Patients Undergoing FFR",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Coronary Artery Disease"
      ],
      "interventions": [
        {
          "name": "OCT stent guidance",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Abbott Medical Devices",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 418,
      "start_date": "2012-12-11",
      "completion_date": "2015-10",
      "has_results": true,
      "last_update_posted_date": "2020-07-02",
      "last_synced_at": "2026-06-10T09:32:50.059Z",
      "location_count": 15,
      "location_summary": "Birmingham, Alabama • La Jolla, California • Orlando, Florida + 12 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Orlando",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Maywood",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01663896"
    },
    {
      "nct_id": "NCT00472732",
      "title": "Neurologic Injuries in Adults With Urea Cycle Disorders",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Brain Diseases, Metabolic, Inborn",
        "Urea Cycle Disorder",
        "Ornithine Transcarbamylase Deficiency"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Andrea Gropman",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 46,
      "start_date": "2007-03",
      "completion_date": "2010-07",
      "has_results": true,
      "last_update_posted_date": "2015-06-24",
      "last_synced_at": "2026-06-10T09:32:50.059Z",
      "location_count": 2,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00472732"
    },
    {
      "nct_id": "NCT05299710",
      "title": "Ovarian Tissue Cryopreservation in Pre-Pubertal (OTC-Pre Pubertal)",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cancers"
      ],
      "interventions": [
        {
          "name": "Laparoscopic surgery",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Erin Rowell",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "11 Years",
        "sex": "FEMALE",
        "summary": "Up to 11 Years · Female only"
      },
      "enrollment_count": 250,
      "start_date": "2018-05-29",
      "completion_date": "2035-01",
      "has_results": false,
      "last_update_posted_date": "2024-11-18",
      "last_synced_at": "2026-06-10T09:32:50.059Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05299710"
    },
    {
      "nct_id": "NCT03181828",
      "title": "Manipulating the Gut Microbiome Study",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Urea Cycle Disorder"
      ],
      "interventions": [
        {
          "name": "Acetohydroxamic Acid Oral Tablet",
          "type": "DRUG"
        },
        {
          "name": "No treatment",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Nicholas Ah Mew",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 4,
      "start_date": "2017-03-24",
      "completion_date": "2018-06-05",
      "has_results": true,
      "last_update_posted_date": "2021-12-15",
      "last_synced_at": "2026-06-10T09:32:50.059Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03181828"
    },
    {
      "nct_id": "NCT01624311",
      "title": "Pilot Study For Hypothermia Treatment In Hyperammonemic Encephalopathy In Neonates And Very Young Infants",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Urea Cycle Disorders",
        "Organic Acidemias"
      ],
      "interventions": [
        {
          "name": "Therapeutic Hypothermia",
          "type": "OTHER"
        },
        {
          "name": "Standard of Care Therapy",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Uta Lichter-Konecki",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Day",
        "maximum_age": "30 Days",
        "sex": "ALL",
        "summary": "1 Day to 30 Days"
      },
      "enrollment_count": 5,
      "start_date": "2007-08",
      "completion_date": "2015-05",
      "has_results": false,
      "last_update_posted_date": "2015-06-01",
      "last_synced_at": "2026-06-10T09:32:50.059Z",
      "location_count": 3,
      "location_summary": "Washington D.C., District of Columbia • New York, New York • Milwaukee, Wisconsin",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Milwaukee",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01624311"
    },
    {
      "nct_id": "NCT04269122",
      "title": "A Study to Assess Plasma Ammonia Time-Normalized Area Under the Curve and Rate of Ureagenesis in Healthy Adult Subjects",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Ornithine Transcarbamylase Deficiency"
      ],
      "interventions": [
        {
          "name": "No Intervention",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Ultragenyx Pharmaceutical Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 120,
      "start_date": "2019-08-02",
      "completion_date": "2020-02-20",
      "has_results": false,
      "last_update_posted_date": "2020-03-30",
      "last_synced_at": "2026-06-10T09:32:50.059Z",
      "location_count": 1,
      "location_summary": "Austin, Texas",
      "locations": [
        {
          "city": "Austin",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04269122"
    },
    {
      "nct_id": "NCT04602325",
      "title": "Systemic Biomarkers of Brain Injury From Hyperammonemia",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Urea Cycle Disorder",
        "Organic Acidemia",
        "Maple Syrup Urine Disease",
        "Glutaric Acidemia I",
        "Fatty Acid Oxidation Disorder",
        "Hypoxic-Ischemic Encephalopathy"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Children's National Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "7 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "7 Years to 18 Years"
      },
      "enrollment_count": 24,
      "start_date": "2020-07-09",
      "completion_date": "2027-05",
      "has_results": false,
      "last_update_posted_date": "2024-02-07",
      "last_synced_at": "2026-06-10T09:32:50.059Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04602325"
    },
    {
      "nct_id": "NCT01568749",
      "title": "A Study Investigating the Pharmacokinetic Profiles of Four Extended Release Paracetamol Formulations",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Analgesia"
      ],
      "interventions": [
        {
          "name": "Paracetamol",
          "type": "DRUG"
        },
        {
          "name": "Paracetamol formulation 1",
          "type": "DRUG"
        },
        {
          "name": "Paracetamol Formulation 2",
          "type": "DRUG"
        },
        {
          "name": "Paracetamol formulation 3",
          "type": "DRUG"
        },
        {
          "name": "Paracetamol formulation 4",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "GlaxoSmithKline",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 14,
      "start_date": "2008-12",
      "completion_date": "2009-08",
      "has_results": false,
      "last_update_posted_date": "2014-11-24",
      "last_synced_at": "2026-06-10T09:32:50.059Z",
      "location_count": 1,
      "location_summary": "Phoenix, Arizona",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01568749"
    },
    {
      "nct_id": "NCT01345578",
      "title": "Hepatocyte Transplantation for Liver Based Metabolic Disorders",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Metabolic Diseases"
      ],
      "interventions": [
        {
          "name": "human hepatocyte transplantation",
          "type": "DRUG"
        },
        {
          "name": "Preparative Radiation Therapy",
          "type": "RADIATION"
        }
      ],
      "intervention_types": [
        "DRUG",
        "RADIATION"
      ],
      "sponsor": "Ira Fox",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "21 Years",
        "sex": "ALL",
        "summary": "Up to 21 Years"
      },
      "enrollment_count": 5,
      "start_date": "2011-03",
      "completion_date": "2022-03-31",
      "has_results": false,
      "last_update_posted_date": "2022-12-07",
      "last_synced_at": "2026-06-10T09:32:50.059Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01345578"
    }
  ]
}