{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Orthodontic+Appliances",
    "query": {
      "condition": "Orthodontic Appliances"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 14,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Orthodontic+Appliances&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-24T22:20:49.338Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02267811",
      "title": "The Effect of OrthoPulse™ on the Rate of Orthodontic Tooth Movement",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Malocclusion"
      ],
      "interventions": [
        {
          "name": "Orthodontic Treatment",
          "type": "OTHER"
        },
        {
          "name": "OrthoPulse™",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DEVICE"
      ],
      "sponsor": "Biolux Research Holdings, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "11 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "11 Years to 60 Years"
      },
      "enrollment_count": 33,
      "start_date": "2013-10",
      "completion_date": "2016-06",
      "has_results": true,
      "last_update_posted_date": "2019-05-21",
      "last_synced_at": "2026-07-24T22:20:49.338Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02267811"
    },
    {
      "nct_id": "NCT03202355",
      "title": "The Effect of OrthoPulse Photobiomodulation on the Rate of Tooth Movement During Alignment With Fixed Appliances",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Malocclusion"
      ],
      "interventions": [
        {
          "name": "Fixed Appliance Orthodontic Treatment",
          "type": "DEVICE"
        },
        {
          "name": "OrthoPulse™",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Biolux Research Holdings, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "11 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "11 Years to 60 Years"
      },
      "enrollment_count": 10,
      "start_date": "2017-04-20",
      "completion_date": "2019-03-11",
      "has_results": false,
      "last_update_posted_date": "2019-04-08",
      "last_synced_at": "2026-07-24T22:20:49.338Z",
      "location_count": 3,
      "location_summary": "Chandler, Arizona • Peoria, Arizona • Phoenix, Arizona",
      "locations": [
        {
          "city": "Chandler",
          "state": "Arizona"
        },
        {
          "city": "Peoria",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03202355"
    },
    {
      "nct_id": "NCT02119455",
      "title": "Biomarkers of Orthodontic Tooth Movement With Fixed Appliances and Vibration Appliance Therapy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tooth Movement"
      ],
      "interventions": [
        {
          "name": "Vibration Device",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "UConn Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "15 Years",
        "maximum_age": "35 Years",
        "sex": "MALE",
        "summary": "15 Years to 35 Years · Male only"
      },
      "enrollment_count": 40,
      "start_date": "2014-04",
      "completion_date": "2018-06",
      "has_results": true,
      "last_update_posted_date": "2019-12-13",
      "last_synced_at": "2026-07-24T22:20:49.338Z",
      "location_count": 1,
      "location_summary": "Farmington, Connecticut",
      "locations": [
        {
          "city": "Farmington",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02119455"
    },
    {
      "nct_id": "NCT06814262",
      "title": "Effect of Clear Aligner Attachment Size on Extrusion of Maxillary Lateral Incisors",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Orthodontic Appliance Complication"
      ],
      "interventions": [
        {
          "name": "Corresponding treatment order in the prescription with Align Technology",
          "type": "DEVICE"
        },
        {
          "name": "Superimposition of final and initial positions of lateral incisors: Predicted model",
          "type": "DEVICE"
        },
        {
          "name": "Superimposition of final and initial positions of lateral incisors: Gingivally beveled 1x1x3mm aligners",
          "type": "DEVICE"
        },
        {
          "name": "Superimposition of final and initial positions of lateral incisors: Gingivally beveled 1x1x4mm aligners",
          "type": "DEVICE"
        },
        {
          "name": "Superimposition of final and initial positions of lateral incisors: Gingivally beveled 1x1x5mm aligners",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Virginia Commonwealth University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "12 Years and older"
      },
      "enrollment_count": 28,
      "start_date": "2025-03-31",
      "completion_date": "2026-06-01",
      "has_results": false,
      "last_update_posted_date": "2026-06-08",
      "last_synced_at": "2026-07-24T22:20:49.338Z",
      "location_count": 1,
      "location_summary": "Richmond, Virginia",
      "locations": [
        {
          "city": "Richmond",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06814262"
    },
    {
      "nct_id": "NCT03306433",
      "title": "Prevention of Enamel Demineralization by Use of K18-smooth Surface Sealant",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "UDMA-K18 smooth surface sealant",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "12 Years to 89 Years"
      },
      "enrollment_count": 16,
      "start_date": "2018-01-08",
      "completion_date": "2018-12-07",
      "has_results": true,
      "last_update_posted_date": "2021-10-07",
      "last_synced_at": "2026-07-24T22:20:49.338Z",
      "location_count": 1,
      "location_summary": "Aurora, Colorado",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03306433"
    },
    {
      "nct_id": "NCT05650359",
      "title": "Study of the Use of Orthopulse Photobiomodulation",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Orthodontics"
      ],
      "interventions": [
        {
          "name": "OrthoPulse",
          "type": "DEVICE"
        },
        {
          "name": "No intervention",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Biolux Technology GmbH",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 42,
      "start_date": "2022-10-13",
      "completion_date": "2028-05-15",
      "has_results": false,
      "last_update_posted_date": "2024-08-07",
      "last_synced_at": "2026-07-24T22:20:49.338Z",
      "location_count": 1,
      "location_summary": "Chandler, Arizona",
      "locations": [
        {
          "city": "Chandler",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05650359"
    },
    {
      "nct_id": "NCT06426238",
      "title": "Self-reported and Experimental Pain in Patients Undergoing Orthodontic Treatment",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Pain"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Midwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "14 Years and older"
      },
      "enrollment_count": 38,
      "start_date": "2024-01-03",
      "completion_date": "2025-06-01",
      "has_results": false,
      "last_update_posted_date": "2025-06-08",
      "last_synced_at": "2026-07-24T22:20:49.338Z",
      "location_count": 1,
      "location_summary": "Downers Grove, Illinois",
      "locations": [
        {
          "city": "Downers Grove",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06426238"
    },
    {
      "nct_id": "NCT04002232",
      "title": "Prevention of Enamel Demineralization Using CPP-ACP-NaF Varnish",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Demineralization"
      ],
      "interventions": [
        {
          "name": "CPP-ACP-NaF varnish",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "10 Years to 80 Years"
      },
      "enrollment_count": 30,
      "start_date": "2019-07-12",
      "completion_date": "2019-12-05",
      "has_results": false,
      "last_update_posted_date": "2021-06-07",
      "last_synced_at": "2026-07-24T22:20:49.338Z",
      "location_count": 1,
      "location_summary": "Aurora, Colorado",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04002232"
    },
    {
      "nct_id": "NCT04186065",
      "title": "The Prevalence of White Spot Lesions During Orthodontic Treatment With Fixed Appliances",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Hiroko Nagaoka",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "10 Years to 70 Years"
      },
      "enrollment_count": 111,
      "start_date": "2019-03-01",
      "completion_date": "2019-10-31",
      "has_results": false,
      "last_update_posted_date": "2020-06-24",
      "last_synced_at": "2026-07-24T22:20:49.338Z",
      "location_count": 1,
      "location_summary": "Lexington, Kentucky",
      "locations": [
        {
          "city": "Lexington",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04186065"
    },
    {
      "nct_id": "NCT07217756",
      "title": "Impact of Increased Body Mass Index on Adolescent Fixed Orthodontic Treatment. A Prospective Longitudinal Study",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Obesity & Overweight",
        "Orthodontic Treatment"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of Rochester",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "12 Years to 18 Years"
      },
      "enrollment_count": 52,
      "start_date": "2022-04-22",
      "completion_date": "2026-11-01",
      "has_results": false,
      "last_update_posted_date": "2025-10-20",
      "last_synced_at": "2026-07-24T22:20:49.338Z",
      "location_count": 1,
      "location_summary": "Rochester, New York",
      "locations": [
        {
          "city": "Rochester",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07217756"
    }
  ]
}